Non-invasive determination of respiratory effort in spontaneous breathing and support ventilation: a validation study with healthy volunteers
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Kristel Lopez-Navas
,
Sebastian Brandt
Abstract
The proper setting of support ventilation aims to follow the patients’ demands, ensuring adequate assistance to their respiratory effort. Effort assessment is thus necessary. But invasive procedures like measuring transdiaphragmatic pressure (Pdi) are impractical in long-term ventilation. Our purpose was therefore the development of the Occlusion+Delta (O+D) method for non-invasive continuous assessment of effort, quantified by the inspiratory pressure-time-product (PTPinsp), during ventilatory support. Flow and airway pressure were measured from 25 healthy volunteers at three effort levels. For the non-invasive method, short expiratory occlusions were executed each three to seven cycles to estimate resistance and compliance with a fitting algorithm fed with the differences between occluded and undisturbed cycles. Signals and estimates were then used to calculate the effort. For the validation of O+D, its estimations were compared to the results from invasive measurement of Pdi using balloon catheters. The agreement between PTPinsp from the invasive measurement and the proposed alternative was confirmed by regression analysis (PTPO+D=1.13PTPPdi- 0.85, R²=0.84) and calculation of their differences (mean±SD=1.78±7.18 cm H2O s). Repeated execution of the non-invasive O+D method facilitates a safe automatic assessment of respiratory mechanics and breathing effort, promoting the rapid recognition of changes in patient’s demands and the adaptation of support.
Acknowledgments
We acknowledge the support of the European Union and the State Schleswig-Holstein. Program for the Future-Economy: 122-09-024.
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©2014 by De Gruyter
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- Non-invasive determination of respiratory effort in spontaneous breathing and support ventilation: a validation study with healthy volunteers
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Articles in the same Issue
- Frontmatter
- Editorial
- Neural probes – microsystems to interface with the brain
- Special issue articles
- Application of floating silicon-based linear multielectrode arrays for acute recording of single neuron activity in awake behaving monkeys
- In vivo validation of the electronic depth control probes
- Approaches for drug delivery with intracortical probes
- Multisite monitoring of choline using biosensor microprobe arrays in combination with CMOS circuitry
- Influence of bio-coatings on the recording performance of neural electrodes
- Review
- Review of machine learning and signal processing techniques for automated electrode selection in high-density microelectrode arrays
- Research articles
- Non-invasive determination of respiratory effort in spontaneous breathing and support ventilation: a validation study with healthy volunteers
- Synchronization analysis between heart rate variability and EEG activity before, during, and after epileptic seizure
- Automated detection of circinate exudates in retina digital images using empirical mode decomposition and the entropy and uniformity of the intrinsic mode functions
