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Synchronization analysis between heart rate variability and EEG activity before, during, and after epileptic seizure

  • Diana Piper , Karin Schiecke , Lutz Leistritz , Britta Pester , Franz Benninger , Martha Feucht , Mihaela Ungureanu , Rodica Strungaru and Herbert Witte EMAIL logo
Published/Copyright: April 1, 2014

Abstract

An innovative concept for synchronization analysis between heart rate (HR) components and rhythms in EEG envelopes is represented; it applies time-variant analyses to heart rate variability (HRV) and EEG, and it was tested in children with temporal lobe epilepsy (TLE). After a removal of ocular and movement-related artifacts, EEG band activity was computed by means of the frequency-selective Hilbert transform providing envelopes of frequency bands. Synchronization between HRV and EEG envelopes was quantified by Morlet wavelet coherence. A surrogate data approach was adapted to test for statistical significance of time-variant coherences. Using this processing scheme, significant coherence values between a HRV low-frequency sub-band (0.08–0.12 Hz) and the EEG δ envelope (1.5–4 Hz) occurring both in the preictal and early postictal periods of a seizure can be shown. Investigations were performed for all electrodes at 20-s intervals and for selected electrode pairs (T3÷C3, T4÷C4) in a time-variant mode. Synchronization was more pronounced in the group of right hemispheric TLE patients than in the left hemispheric group. Such a group-specific augmentation of synchronization confirms the hypothesis of a right hemispheric lateralization of sympathetic cardiac control of the low-frequency HRV components.


Corresponding author: Prof. Dr. Herbert Witte, Institute of Medical Statistics, Computer Sciences and Documentation, Jena University Hospital, Friedrich Schiller University Jena, 07740 Jena, Phone: +49 3641933982, Fax: +49 3641933200, E-mail:

Acknowledgment

This work was supported by the DFG under Wi 1166/12-1 and by the Romanian Ministry of Labour, Family and Social Protection through the Financial Agreement POSDRU/107/1.5/S/76903 (D. Piper).

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Received: 2013-12-17
Accepted: 2014-2-28
Published Online: 2014-4-1
Published in Print: 2014-8-1

©2014 by De Gruyter

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