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Implant-associated local drug delivery systems based on biodegradable polymers: customized designs for different medical applications

  • Katrin Sternberg EMAIL logo , Svea Petersen , Niels Grabow , Volkmar Senz , Henriette Meyer zu Schwabedissen , Heyo K. Kroemer and Klaus-Peter Schmitz
Published/Copyright: June 12, 2013

Abstract

Implants providing controlled, local release of active substances are of interest in different medical applications. Therefore, the focus of the present article is the development of implant-associated diffusion- or chemically controlled local drug delivery (LDD) systems based on biodegradable polymeric drug carriers. In this context, we provide new data and review our own recently published data concerning the drug release behavior of diffusion-controlled LDD systems in relation to the kind of polymer, drug content, coating mass/thickness, and layer composition. We demonstrate that polymers allow a wide range of control over the drug release characteristics. In this regard, we show that the glass transition temperature of a polymer has an impact on its drug release. Additionally, the blending of hydrophobic, semicrystalline polymers with amorphous polymers leads to an increase in the rate of drug release compared with the pure semicrystalline polymer. Moreover, the percentage loading of the embedded drug has a considerable effect on the rate and duration of drug release. Furthermore, we discuss chemically controlled LDD systems designed for the release of biomolecules, such as growth factors, as well as nanoparticle-mediated LDD systems. With our own published data on drug-eluting stents, microstents, and cochlear implants, we highlight exemplary implant-associated LDD systems designed to improve implant performance through the reduction of undesirable effects such as in-stent restenosis and fibrosis.


Corresponding author: Prof. Dr. Katrin Sternberg, Institute for Biomedical Engineering, University of Rostock, Friedrich-Barnewitz-Straße 4, 18119 Rostock, Germany, E-mail:

The authors would like to thank Thomas Langer, Thomas Reske, Daniela Arbeiter, Peter Littwin, Martina Schröder, and Andrea Rohde for their technical assistance. Furthermore, the Tepha Inc. (Lexington, MA, USA) is acknowledged for the supply of the polymeric biomaterial P(4HB), especially David Martin for his helpful suggestions. Parts of this work were funded by the Deutsche Forschungsgemeinschaft (DFG) within SFB Transregio 37 “Mikro- und Nanosysteme in der Medizin – Rekonstruktion biologischer Funktionen” (GZ: TRR 37) and the Bundesministerium für Bildung und Forschung (BMBF) within REMEDIS “Höhere Lebensqualität durch neuartige Mikroimplantate” (FKZ: 03IS2081).

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Received: 2012-12-14
Accepted: 2013-5-17
Published Online: 2013-06-12
Published in Print: 2013-10-01

©2013 by Walter de Gruyter Berlin Boston

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