Coagulation and fibrinolysis related cytokine imbalance in preeclampsia: the role of placental trophoblasts
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Yin-Cheng Teng
Abstract
Objective: Cytokine imbalance might have a pivotal role in hypercoagulability seen in preeclampsia. Our objective was to determine the relationship of blood coagulation related factors in placental tissue and peripheral blood in preeclamptic and normal pregnancies.
Methods: We compared mRNA and protein levels of tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), and tissue factor (TF) in the placenta of normal and preeclamptic pregnancies. Placental and peripheral blood t-PA and PAI-1 levels were examined. Trophoblasts were used to study the effects of hypoxia, hypoxia-reperfusion, and inflammatory cytokines on t-PA, PAI-1, tissue factor pathway inhibitor (TFPI), and TF.
Results: PAI-1 and TF mRNA and protein levels were higher in placental tissue of preeclamptic pregnancies and in the peripheral blood of patients with preeclampsia. mRNA and protein secretion of TF, TFPI, PAI-1, but not t-PA, was increased in trophoblast cell culture under hypoxia and hypoxia-reoxygenation. Cell cultures with high levels of tumor necrosis factor-alpha (TNF-α) exhibited increased expression and secretion of TF and PAI-1, decreased TFPI, and no significant change of t-PA.
Conclusions: Imbalanced synthesis of t-PA, PAI-1, TFPI, and TF in trophoblasts may contribute to hypercoagulability in patients with preeclampsia.
©2009 by Walter de Gruyter Berlin New York
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- Parental mental representations during late pregnancy and early parenthood following assisted reproductive technology
- Does progesterone inhibit bacteria-stimulated interleukin-8 production by lower genital tract epithelial cells?
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- Maternal serum adiponectin multimers in preeclampsia
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- Changes in symphysis pubis width during labor
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- Determination of fetal heart rate reactivity from a single 20-min window of non-stress testing in compromised fetuses
- Detailed multigrade evaluation of fetal disorders with the quantified actocardiogram
- Original articles – Newborn
- Parental mental health and child development from six to thirty-six months in a birth cohort study in Taiwan
- Oxygen saturation in healthy newborns; influence of birth weight and mode of delivery
- Effect of sitting position on respiratory status in preterm infants
- Circadian variation on oxygen consumption in preterm infants
- Letters to the Editor
- Obstetrical chondro-epiphyseal separation of the distal humerus: a case report and review of literature
- Post-term pregnancy as a risk factor for intrapartum fetal distress
- Severe neonatal hyporegenerative anemia due to anti-Vw (anti-MNS9) alloantibody
- A new device to facilitate the chorion villus sampling
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- Congress Calender
- Congress Calendar
Articles in the same Issue
- Original articles – Obstetrics
- The effect of bilateral pelvic neurectomy on uterine and abdominal electrical and pressure activity, as measured by telemetry in conscious, unrestrained pregnant rats
- Parental mental representations during late pregnancy and early parenthood following assisted reproductive technology
- Does progesterone inhibit bacteria-stimulated interleukin-8 production by lower genital tract epithelial cells?
- Flowcytometric assessment of fetomaternal hemorrhage during external cephalic version at term
- Progesterone – induced blocking factor (PIBF) and Th1/Th2 cytokine in women with threatened spontaneous abortion
- Coagulation and fibrinolysis related cytokine imbalance in preeclampsia: the role of placental trophoblasts
- Maternal serum adiponectin multimers in preeclampsia
- Effect of maternal smoking on cord blood estriol, placental lactogen, chorionic gonadotropin, FSH, LH, and cortisol
- Changes in symphysis pubis width during labor
- Temporal trends in pregnancy weight gain and birth weight in Bavaria 2000–2007: slightly decreasing birth weight with increasing weight gain in pregnancy
- Original articles – Fetus
- Embryo vascularization by three-dimensional power Doppler ultrasonography at 7–10 weeks of pregnancy
- Determination of fetal heart rate reactivity from a single 20-min window of non-stress testing in compromised fetuses
- Detailed multigrade evaluation of fetal disorders with the quantified actocardiogram
- Original articles – Newborn
- Parental mental health and child development from six to thirty-six months in a birth cohort study in Taiwan
- Oxygen saturation in healthy newborns; influence of birth weight and mode of delivery
- Effect of sitting position on respiratory status in preterm infants
- Circadian variation on oxygen consumption in preterm infants
- Letters to the Editor
- Obstetrical chondro-epiphyseal separation of the distal humerus: a case report and review of literature
- Post-term pregnancy as a risk factor for intrapartum fetal distress
- Severe neonatal hyporegenerative anemia due to anti-Vw (anti-MNS9) alloantibody
- A new device to facilitate the chorion villus sampling
- Correct definition of pentalogy of Cantrell
- Congress Calender
- Congress Calendar
