Progesterone – induced blocking factor (PIBF) and Th1/Th2 cytokine in women with threatened spontaneous abortion
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Igor Hudić
Abstract
Objective: The aim of this prospective study was to compare serum and urine concentrations of progesterone-induced blocking factor (PIBF) and serum concentrations of anti-inflammatory (IL10) and pro-inflammatory (IL6, TNFα, IFNγ) cytokines of women with threatened spontaneous abortion with normal pregnancy and to evaluate the impact of PIBF on outcome of pregnancy.
Methods: A sample of 30 women with threatened spontaneous abortion (study group) and 20 healthy pregnant women (control group) between 6th and 24th gestational weeks was studied. Serum and urine PIBF, IL10 and IL6, TNFα, IFNγ cytokine concentrations were measured by enzyme-linked immunosorbent assay (ELISA).
Results: Five (16.7%) pregnancies in the study group ended missed abortion vs. none in the control group (P<0.05). Five (20%) threatened aborters delivered between 24th and 37th weeks of gestation, whereas two (10%) preterm deliveries occurred in the controls (P>0.05). PIBF concentrations in urine (19.5±12.9 ng/mL) and serum (214.4±120.6 of patients with threatened abortion were significantly lower than in healthy pregnant women (45.3±33.7 ng/mL and 357.3±159.9 ng/mL, respectively). Women with threatened abortion had significantly lower serum levels of anti-inflammatory cytokine, but levels of proinflammatory cytokines were higher in this group compared with healthy controls.
Conclusions: Determination of progesteron-induced blocking factor level in body fluids in early pregnancy might be used for the diagnosis and prognosis of threatened abortion.
©2009 by Walter de Gruyter Berlin New York
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- Congress Calender
- Congress Calendar
Articles in the same Issue
- Original articles – Obstetrics
- The effect of bilateral pelvic neurectomy on uterine and abdominal electrical and pressure activity, as measured by telemetry in conscious, unrestrained pregnant rats
- Parental mental representations during late pregnancy and early parenthood following assisted reproductive technology
- Does progesterone inhibit bacteria-stimulated interleukin-8 production by lower genital tract epithelial cells?
- Flowcytometric assessment of fetomaternal hemorrhage during external cephalic version at term
- Progesterone – induced blocking factor (PIBF) and Th1/Th2 cytokine in women with threatened spontaneous abortion
- Coagulation and fibrinolysis related cytokine imbalance in preeclampsia: the role of placental trophoblasts
- Maternal serum adiponectin multimers in preeclampsia
- Effect of maternal smoking on cord blood estriol, placental lactogen, chorionic gonadotropin, FSH, LH, and cortisol
- Changes in symphysis pubis width during labor
- Temporal trends in pregnancy weight gain and birth weight in Bavaria 2000–2007: slightly decreasing birth weight with increasing weight gain in pregnancy
- Original articles – Fetus
- Embryo vascularization by three-dimensional power Doppler ultrasonography at 7–10 weeks of pregnancy
- Determination of fetal heart rate reactivity from a single 20-min window of non-stress testing in compromised fetuses
- Detailed multigrade evaluation of fetal disorders with the quantified actocardiogram
- Original articles – Newborn
- Parental mental health and child development from six to thirty-six months in a birth cohort study in Taiwan
- Oxygen saturation in healthy newborns; influence of birth weight and mode of delivery
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- Letters to the Editor
- Obstetrical chondro-epiphyseal separation of the distal humerus: a case report and review of literature
- Post-term pregnancy as a risk factor for intrapartum fetal distress
- Severe neonatal hyporegenerative anemia due to anti-Vw (anti-MNS9) alloantibody
- A new device to facilitate the chorion villus sampling
- Correct definition of pentalogy of Cantrell
- Congress Calender
- Congress Calendar
