Risk assessment of trisomy 21 by maternal age and fetal nuchal translucency thickness in 7096 unselected pregnancies in Slovenia
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Darija M. Strah
Abstract
Aim: To evaluate the screening for trisomy 21 by maternal age and nuchal translucency in a low-risk population.
Methods: Screening was performed in 7096 singleton pregnancies. The estimated risk for trisomy 21, the detection rate (DR), false positive rate (FPR) and the cut-off nuchal translucency thickness to obtain a 5% FPR were calculated.
Results: The median maternal age was 28.6 years. The estimated risk for trisomy 21 was 1 in 300 or greater in 2.4% (171 of 7096) of all pregnancies and in 75% (9 of 12) of trisomy 21 pregnancies. The DR for all aneuploidies was 83.3%, and 75% for trisomy 21. The estimated FPR at risk 1 in 300 for the whole population in 2004 was 3.8%. It is predicted to remain below 4% at least until 2007; to achieve a 5% FPR in 2007 the risk limit 1 in 400 is proposed.
Conclusions: Screening for trisomy 21 in a low-risk population in Slovenia gives comparable results to those in other countries. The only result that varies is the percentage of screen positive patients at the risk limit 1 in 300. We believe the risk limit should be specifically estimated for each country based on its population distribution of maternal age.
©2008 by Walter de Gruyter Berlin New York
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Articles in the same Issue
- Prenatal long-chain polyunsaturated fatty acid status: the importance of a balanced intake of docosahexaenoic acid and arachidonic acid
- Population-based standardization (PBS) of institutional cesarean delivery rates
- Impact of high maternal hemoglobin at first antenatal visit on pregnancy outcomes: a cohort study
- Retrospective audit of outcome of regional anesthesia for delivery in women with thrombocytopenia
- The association between maternal characteristics and different types and levels of discordance in triplet pregnancies
- Obstetric gel shortens second stage of labor and prevents perineal trauma in nulliparous women: a randomized controlled trial on labor facilitation
- Fetal electrocardiographic monitoring during labor in relation to cord blood levels of the brain-injury marker protein S-100
- Nuchal cord in post-term pregnancy – relationship to suspected intrapartum fetal distress indicating operative intervention
- Risk assessment of trisomy 21 by maternal age and fetal nuchal translucency thickness in 7096 unselected pregnancies in Slovenia
- The association of hypotonia and depression in the term and near-term neonate with metabolic acidemia
- 17-Hydroxyprogesterone in premature infants as a marker of intrauterine stress
- Prenatal hypoxia preconditioning improves hypoxic ventilatory response and reduces mortality in neonatal rats
- Mortality and morbidity of neonates born at <26 weeks of gestation (1998–2003). A population-based study
- Conception without the development of a human being
- Intraplacental choriocarcinoma with fetomaternal hemorrhage: a case study and literature review
- Computerized FHR traces in post-term pregnancies
- Uterine activity monitoring during labor
- Congress Calendar
