Fetal electrocardiographic monitoring during labor in relation to cord blood levels of the brain-injury marker protein S-100
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Andrea Stuart
Abstract
Background: Cord artery protein S-100 levels at birth are potential markers of brain damage after asphyxia. Our aim was to investigate if S-100 levels were elevated in neonates with indirect signs of asphyxia during birth. S-100 levels in cord blood were studied in relation to cardiotocography (CTG) and fetal electrocardiography (FECG) changes during birth and to acidemia in umbilical blood.
Material and methods: This case-control study was performed in parallel to a large randomized controlled trial (RCT) studying FECG at birth. Protein S-100 samples were collected from 103 neonates at birth and related to the CTG and ECG changes during labor and to pH in umbilical blood.
Results: Protein S-100 was significantly higher in neonates with umbilical artery blood pH≤7.05, compared to neonates with pH>7.05. Furthermore, neonates with preterminal CTG patterns showed increased S-100 levels compared to neonates with normal CTG. Neonates having significant CTG and ECG changes, leading to intervention according to clinical guidelines, showed significantly higher S-100 levels compared to neonates without such indication of intervention.
Conclusion: A relation exists between S-100 in umbilical blood at birth, acidosis and pathological patterns in CTG and FECG during labor.
©2008 by Walter de Gruyter Berlin New York
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Articles in the same Issue
- Prenatal long-chain polyunsaturated fatty acid status: the importance of a balanced intake of docosahexaenoic acid and arachidonic acid
- Population-based standardization (PBS) of institutional cesarean delivery rates
- Impact of high maternal hemoglobin at first antenatal visit on pregnancy outcomes: a cohort study
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- The association between maternal characteristics and different types and levels of discordance in triplet pregnancies
- Obstetric gel shortens second stage of labor and prevents perineal trauma in nulliparous women: a randomized controlled trial on labor facilitation
- Fetal electrocardiographic monitoring during labor in relation to cord blood levels of the brain-injury marker protein S-100
- Nuchal cord in post-term pregnancy – relationship to suspected intrapartum fetal distress indicating operative intervention
- Risk assessment of trisomy 21 by maternal age and fetal nuchal translucency thickness in 7096 unselected pregnancies in Slovenia
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- 17-Hydroxyprogesterone in premature infants as a marker of intrauterine stress
- Prenatal hypoxia preconditioning improves hypoxic ventilatory response and reduces mortality in neonatal rats
- Mortality and morbidity of neonates born at <26 weeks of gestation (1998–2003). A population-based study
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- Computerized FHR traces in post-term pregnancies
- Uterine activity monitoring during labor
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