Prenatal hypoxia preconditioning improves hypoxic ventilatory response and reduces mortality in neonatal rats
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Rurong Wang
Abstract
Objective: Severe hypoxia/ischemia is a major cause of neonatal cardiorespiratory dysfunction and mortality. We tested whether prenatal hypoxia preconditioning would augment hypoxic and hypercapnic ventilatory responses, and thereby reduce neonatal mortality.
Methods: Pregnant rats at 19 days' gestation were exposed to six episodes of intermittent hypoxia (10-min of 15% O2 followed by 10-min of normoxia/episode, PPC), or room air (CON) per day until delivery. The ventilatory responses to 1 min of 10% O2 and 10% CO2, and 5 min of 5% O2 were performed in anesthetized pups. The conscious pups were exposed to 5% O2 for ∼105 min, and their mortality and dry/wet weight of the lung and brain were evaluated.
Results: We found that augmented ventilatory responses to 1 min of 10% O2 and 10% CO2 were similar in the two groups (P>0.05). In contrast, 5 min of 5% O2 initially caused a ventilatory peak response followed by a decline that was markedly diminished (35%, P=0.013) by PPC. PPC also significantly decreased neonatal mortality by 22% (P=0.044) as compared with CON.
Conclusion: We conclude that prenatal hypoxia preconditioning reduces neonatal mortality apparently by improving the severe hypoxic ventilatory response.
©2008 by Walter de Gruyter Berlin New York
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- Prenatal long-chain polyunsaturated fatty acid status: the importance of a balanced intake of docosahexaenoic acid and arachidonic acid
- Population-based standardization (PBS) of institutional cesarean delivery rates
- Impact of high maternal hemoglobin at first antenatal visit on pregnancy outcomes: a cohort study
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- The association between maternal characteristics and different types and levels of discordance in triplet pregnancies
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- Risk assessment of trisomy 21 by maternal age and fetal nuchal translucency thickness in 7096 unselected pregnancies in Slovenia
- The association of hypotonia and depression in the term and near-term neonate with metabolic acidemia
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- Prenatal hypoxia preconditioning improves hypoxic ventilatory response and reduces mortality in neonatal rats
- Mortality and morbidity of neonates born at <26 weeks of gestation (1998–2003). A population-based study
- Conception without the development of a human being
- Intraplacental choriocarcinoma with fetomaternal hemorrhage: a case study and literature review
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