Primary ovarian dysfunction after hematopoietic stem cell transplantation during childhood: busulfan-based conditioning is a major concern
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        Won-Kyoung Cho
        
 , Jae-Wook Lee , Nak Gyun Chung , Min Ho Jung , Bin Cho , Byung-Kyu Suhand Hack Ki Kim
 
Abstract
We evaluated the incidence of patient/treatment factors associated with primary ovarian failure (POF) after hematopoietic stem cell transplantation (HSCT) during childhood. Fifty girls over 12 years of age (15.0±2.2) who were referred to the pediatric endocrinology clinic between March 2002 and March 2010 after HSCT at the Catholic HSCT center were enrolled in the study. In total, 36 (72%) out of 50 patients developed POF. Twenty-three patients were diagnosed and treated as chronic graft-versus-host disease. As preparative regimens for HSCT, 23 patients received total body irradiation (TBI)-based regimen, 19 received busulfan (BU)-based regimen, 4 received both BU- and TBI-based, and 4 received reduced intensity conditioning regimen. In a univariate logistic regression analysis, the BU-based regimen (p=0.028) showed a strong relationship with POF. The incidence of POF according to the route of BU administration, between orally and intravenously, were not different (p=0.435). These results emphasize the importance of monitoring these patients at regular intervals and the need to develop complementary HSCT protocols for preventing POF in children.
©2011 by Walter de Gruyter Berlin Boston
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Articles in the same Issue
- Editorial
 - Intracranial cysts: large-scale information is needed
 - Reviews
 - The endocrine spectrum of intracranial cysts in childhood and review of the literature
 - Radioiodine treatment in pediatric Graves disease and thyroid carcinoma
 - Images in Pediatric Endocrinology
 - Perineal ectopic testis: a rare cause of empty scrotum
 - Original Articles
 - Normal thyroid function in young adults who were born very preterm
 - Does clinical management impact height potential in children with severe acquired hypothyroidism?
 - Neurodevelopment of preterm infants born at 28 to 36 weeks of gestational age: the role of hypothyroxinemia and long-term outcome at 4 years
 - Central hypothyroidism following chemotherapy for acute lymphoblastic leukemia
 - The prevalence of non-alcoholic fatty liver disease and metabolic syndrome in obese children
 - Retinol binding protein 4 is associated with adiposity-related co-morbidity risk factors in children
 - Circulating adipocyte fatty acid-binding protein, juvenile obesity, and metabolic syndrome
 - Obesity and associated cardiovascular risk factors among schoolchildren in Greece: a cross-sectional study and review of the literature
 - Peptides from adipose tissue in monitoring energy balance in infants
 - Effectiveness of pentoxifylline on the cross-sectional area of intima media thickness and functions of the common carotid artery in adolescents with type 1 diabetes
 - Common adipokine features of neonates and centenarians
 - Congenital adrenal hyperplasia: as viewed by parents of affected children in India – a pilot study
 - Characteristics and prevalence of non-classical congenital adrenal hyperplasia with a V281l mutation in patients with premature pubarche
 - Contribution of bone turnover markers to bone mass in pubertal boys and girls
 - Modifiable factors associated with low bone mineral content in underprivileged premenarchal Indian girls
 - Effect of GnRH analogue on height potential in patients with severe growth hormone insensitivity syndrome treated with IGF-I
 - Measurement of amino-terminal propeptide of C-type natriuretic peptide in patients with idiopathic short stature or isolated growth hormone deficiency
 - Growth hormone treatment, final height, insulin-like growth factors, ghrelin, and adiponectin in four siblings with Seckel syndrome
 - Health promotion intervention in Arab-Israeli kindergarten children
 - Validation of automatic bone age rating in children with precocious and early puberty
 - Interrelationship of carpal angle and bone age in children of different generations: a retrospective study
 - Clinical characteristics of recessive and dominant congenital hyperinsulinism due to mutation(s) in the ABCC8/KCNJ11 genes encoding the ATP-sensitive potasium channel in the pancreatic beta cell
 - Use of nocturnal melatonin concentration and urinary 6-sulfatoxymelatonin excretion to evaluate melatonin status in children with severe sepsis
 - Primary ovarian dysfunction after hematopoietic stem cell transplantation during childhood: busulfan-based conditioning is a major concern
 - Vitamin D status and insulin requirements in children and adolescent with type 1 diabetes
 - Patient Reports
 - Homozygosity for two missense mutations in the leptin receptor gene (P316T;W646C) in a Turkmenian girl with severe early-onset obesity
 - A 3-year-old girl with Graves’ disease with hypoglycemia following transient adrenal hyporesponsiveness
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 - Precocious puberty and empty sella syndrome in a girl cured of acute lymphoblastic leukemia
 - Sex of rearing seems to exert a powerful influence on gender identity in the absence of strong hormonal influence: report of two siblings with PAIS assigned different sex of rearing
 - Transient neonatal diabetes with two novel mutations in the KCNJ11 gene and response to sulfonylurea treatment in a preterm infant
 - Persistent hypoglycemia caused by umbilical arterial catheterization
 - Congestive heart failure as an initial manifestation of reninoma
 - Multiple pterygium syndrome: mimicking the findings of Turner syndrome
 - A neonate with contiguous deletion syndrome in XP21
 - Kocher-Debré-Sémélaigne syndrome with pericardial effusion
 - Meetings
 - Meetings Calendar