Abstract
Background: It has been suggested that chemotherapy per se might impair the hypothalamus-pituitary-thyroid axis of childhood cancer survivors.
Objective: We examined six patients treated for acute lymphoblastic leukemia (ALL) with chemotherapy alone, with suspicious central hypothyroidism (CH).
Subjects and methods: ALL was diagnosed at a mean age of 3.8 years (range 0.3–6 years), the mean follow-up is 6 years (range 6–13 years). Auxological data were recorded, and thyroid function, autoimmunity and ultrasonography (US) were evaluated. Three individuals underwent a thyrotropin-releasing hormone (TRH) test and a magnetic resonance imaging (MRI) scan of the hypothalamic-pituitary region.
Results: All study participants showed negative thyroid autoimmunity, normal thyroid ultrasound, and thyroid-stimulating hormone (TSH) above the normal range; free T4 (fT4) was abnormally low in two patients. After TRH infusion all patients showed TSH increase and slow TSH decline.
Conclusions: Our study shows that CH could arise at any time after childhood leukemia following only chemotherapy treatment. Although overt hypothyroidism was detected in only two patients, a careful follow-up of thyroid function is also recommended for ALL survivors not treated by irradiation.
©2011 by Walter de Gruyter Berlin Boston
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- Radioiodine treatment in pediatric Graves disease and thyroid carcinoma
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- Neurodevelopment of preterm infants born at 28 to 36 weeks of gestational age: the role of hypothyroxinemia and long-term outcome at 4 years
- Central hypothyroidism following chemotherapy for acute lymphoblastic leukemia
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- Effect of GnRH analogue on height potential in patients with severe growth hormone insensitivity syndrome treated with IGF-I
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- Vitamin D status and insulin requirements in children and adolescent with type 1 diabetes
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- Meetings
- Meetings Calendar
Articles in the same Issue
- Editorial
- Intracranial cysts: large-scale information is needed
- Reviews
- The endocrine spectrum of intracranial cysts in childhood and review of the literature
- Radioiodine treatment in pediatric Graves disease and thyroid carcinoma
- Images in Pediatric Endocrinology
- Perineal ectopic testis: a rare cause of empty scrotum
- Original Articles
- Normal thyroid function in young adults who were born very preterm
- Does clinical management impact height potential in children with severe acquired hypothyroidism?
- Neurodevelopment of preterm infants born at 28 to 36 weeks of gestational age: the role of hypothyroxinemia and long-term outcome at 4 years
- Central hypothyroidism following chemotherapy for acute lymphoblastic leukemia
- The prevalence of non-alcoholic fatty liver disease and metabolic syndrome in obese children
- Retinol binding protein 4 is associated with adiposity-related co-morbidity risk factors in children
- Circulating adipocyte fatty acid-binding protein, juvenile obesity, and metabolic syndrome
- Obesity and associated cardiovascular risk factors among schoolchildren in Greece: a cross-sectional study and review of the literature
- Peptides from adipose tissue in monitoring energy balance in infants
- Effectiveness of pentoxifylline on the cross-sectional area of intima media thickness and functions of the common carotid artery in adolescents with type 1 diabetes
- Common adipokine features of neonates and centenarians
- Congenital adrenal hyperplasia: as viewed by parents of affected children in India – a pilot study
- Characteristics and prevalence of non-classical congenital adrenal hyperplasia with a V281l mutation in patients with premature pubarche
- Contribution of bone turnover markers to bone mass in pubertal boys and girls
- Modifiable factors associated with low bone mineral content in underprivileged premenarchal Indian girls
- Effect of GnRH analogue on height potential in patients with severe growth hormone insensitivity syndrome treated with IGF-I
- Measurement of amino-terminal propeptide of C-type natriuretic peptide in patients with idiopathic short stature or isolated growth hormone deficiency
- Growth hormone treatment, final height, insulin-like growth factors, ghrelin, and adiponectin in four siblings with Seckel syndrome
- Health promotion intervention in Arab-Israeli kindergarten children
- Validation of automatic bone age rating in children with precocious and early puberty
- Interrelationship of carpal angle and bone age in children of different generations: a retrospective study
- Clinical characteristics of recessive and dominant congenital hyperinsulinism due to mutation(s) in the ABCC8/KCNJ11 genes encoding the ATP-sensitive potasium channel in the pancreatic beta cell
- Use of nocturnal melatonin concentration and urinary 6-sulfatoxymelatonin excretion to evaluate melatonin status in children with severe sepsis
- Primary ovarian dysfunction after hematopoietic stem cell transplantation during childhood: busulfan-based conditioning is a major concern
- Vitamin D status and insulin requirements in children and adolescent with type 1 diabetes
- Patient Reports
- Homozygosity for two missense mutations in the leptin receptor gene (P316T;W646C) in a Turkmenian girl with severe early-onset obesity
- A 3-year-old girl with Graves’ disease with hypoglycemia following transient adrenal hyporesponsiveness
- Papillary carcinoma masquerading as clinically toxic adenoma in very young children
- Hyperandrogenism in a set of triplets with modification of clinical course by hyperthyroidism
- A case of Langerhans cell histiocytosis with thyroid involvement
- Congenital rhabdomyosarcoma, central precocious puberty, hemihypertrophy and hypophosphatemic rickets associated with epidermal nevus syndrome
- Precocious puberty and empty sella syndrome in a girl cured of acute lymphoblastic leukemia
- Sex of rearing seems to exert a powerful influence on gender identity in the absence of strong hormonal influence: report of two siblings with PAIS assigned different sex of rearing
- Transient neonatal diabetes with two novel mutations in the KCNJ11 gene and response to sulfonylurea treatment in a preterm infant
- Persistent hypoglycemia caused by umbilical arterial catheterization
- Congestive heart failure as an initial manifestation of reninoma
- Multiple pterygium syndrome: mimicking the findings of Turner syndrome
- A neonate with contiguous deletion syndrome in XP21
- Kocher-Debré-Sémélaigne syndrome with pericardial effusion
- Meetings
- Meetings Calendar