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Beverage-specific effects of ethanol consumption on its biological markers
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Hidenari Sakuta
Published/Copyright:
March 10, 2008
Abstract
Background: Serum γ-glutamyltransferase (GGT) and erythrocyte mean corpuscular volume (MCV) are well-known biological markers of excessive ethanol consumption.
Methods: The beverage-specific effects of ethanol consumption on GGT level and MCV value were analyzed cross-sectionally and retrospectively among middle-aged Japanese men who underwent a retirement health checkup (n=974).
Results: Both the consumption of distilled alcohol and that of fermented alcohol positively correlated with the logarithm of GGT [standard regression coefficient (β) 0.261 and 0.174, respectively]. The prevalence rate of elevated GGT levels (≥70 IU/L) was higher among heavy drinkers of distilled alcohol than among heavy drinkers of fermented alcohol (38.8% vs. 27.6%, p=0.013). The MCV value correlated with distilled alcohol consumption (β: 0.212, p<0.0001) but not with fermented alcohol consumption (β: 0.043, not significant). The prevalence rate of an elevated MCV (≥97 fL) was higher among heavy drinkers of distilled alcohol than among heavy drinkers of fermented alcohol (35.3% vs. 16.8%, p<0.001).
Conclusions: These results suggest that MCV is less sensitive for detecting heavy consumption of fermented alcohol than for detecting that of distilled alcohol in apparently healthy middle-aged men.
Clin Chem Lab Med 2008;46:699–702.
Received: 2007-10-8
Accepted: 2007-12-31
Published Online: 2008-03-10
Published in Print: 2008-05-01
©2008 by Walter de Gruyter Berlin New York
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Keywords for this article
alcohol;
fermented alcohol;
γ-glutamyltransferase;
mean corpuscular volume;
spirits
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