Startseite Current potential diagnostic biomarkers of amyotrophic lateral sclerosis
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Current potential diagnostic biomarkers of amyotrophic lateral sclerosis

  • Zheqi Xu ORCID logo und Renshi Xu ORCID logo EMAIL logo
Veröffentlicht/Copyright: 9. Juli 2024
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Reviews in the Neurosciences
Aus der Zeitschrift Reviews in the Neurosciences Band 35 Heft 8

Abstract

Amyotrophic lateral sclerosis (ALS) currently lacks the useful diagnostic biomarkers. The current diagnosis of ALS is mainly depended on the clinical manifestations, which contributes to the diagnostic delay and be difficult to make the accurate diagnosis at the early stage of ALS, and hinders the clinical early therapeutics. The more and more pathogenesis of ALS are found at the last 30 years, including excitotoxicity, the oxidative stress, the mitochondrial dysfunction, neuroinflammation, the altered energy metabolism, the RNA misprocessing and the most recent neuroimaging findings. The findings of these pathogenesis bring the new clues for searching the diagnostic biomarkers of ALS. At present, a large number of relevant studies about the diagnostic biomarkers are underway. The ALS pathogenesis related to the diagnostic biomarkers might lessen the diagnostic reliance on the clinical manifestations. Among them, the cortical altered signatures of ALS patients derived from both structural and functional magnetic resonance imaging and the emerging proteomic biomarkers of neuronal loss and glial activation in the cerebrospinal fluid as well as the potential biomarkers in blood, serum, urine, and saliva are leading a new phase of biomarkers. Here, we reviewed these current potential diagnostic biomarkers of ALS.

Keywords: amyotrophic lateral sclerosis; biomarkers; diagnosis; functional magnetic resonance imaging; neuroinflammation
Corresponding author: Renshi Xu, Department of Neurology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang 330006, China; The Clinical College of Nanchang Medical College, Nanchang 330006, China; and Medical College of Nanchang University, Nanchang 330006, China, E-mail:

Funding source: Jiangxi Provincial Department of Science and Technology

Award Identifier / Grant number: 20192BAB205043

Funding source: National Natural Science Foundation of China

Award Identifier / Grant number: 30560042, 81160161, 81360198, and 82160255

Funding source: Health and Family Planning Commission of Jiangxi Province

Award Identifier / Grant number: 20181019, 202210002 and 202310119

Funding source: Education Department of Jiangxi Province

Award Identifier / Grant number: GJJ13198 and GJJ170021

  1. Research ethics: No applicable.

  2. Author contributions: ZQ wrote the first draft of the manuscript. RX provided critical feedback as supervisor. All authors conceived its content and structure, reviewed, edited, and approved the final manuscript.

  3. Competing interests: All authors declare no potential conflicts of interest with regard to this manuscript. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or conflict with the subject matter or materials discussed in this manuscript.

  4. Research funding: This study was in part funded by the National Natural Science Foundation of China (30560042, 81160161, 81360198, and 82160255), Education Department of Jiangxi Province (GJJ13198 and GJJ170021), Jiangxi Provincial Department of Science and Technology (20192BAB205043) and Health and Family Planning Commission of Jiangxi Province (20181019, 202210002 and 202310119).

  5. Data availability: No any data are available, any data include in this manuscript.

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Received: 2024-03-08
Accepted: 2024-06-13
Published Online: 2024-07-09
Published in Print: 2024-12-17

© 2024 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Role of endothelial glycocalyx in central nervous system diseases and evaluation of the targeted therapeutic strategies for its protection: a review of clinical and experimental data
  3. Research progress on astrocyte-derived extracellular vesicles in the pathogenesis and treatment of neurodegenerative diseases
  4. The role of antibodies in small fiber neuropathy: a review of currently available evidence
  5. Revealing the mechanisms of blood–brain barrier in chronic neurodegenerative disease: an opportunity for therapeutic intervention
  6. Current potential diagnostic biomarkers of amyotrophic lateral sclerosis
  7. The neurobiological mechanisms of photoperiod impact on brain functions: a comprehensive review
  8. Accelerated biological brain aging in major depressive disorder
https://doi.org/10.1515/revneuro-2024-0037
Schlagwörter für diesen Artikel
amyotrophic lateral sclerosis; biomarkers; diagnosis; functional magnetic resonance imaging; neuroinflammation

Artikel in diesem Heft

  1. Frontmatter
  2. Role of endothelial glycocalyx in central nervous system diseases and evaluation of the targeted therapeutic strategies for its protection: a review of clinical and experimental data
  3. Research progress on astrocyte-derived extracellular vesicles in the pathogenesis and treatment of neurodegenerative diseases
  4. The role of antibodies in small fiber neuropathy: a review of currently available evidence
  5. Revealing the mechanisms of blood–brain barrier in chronic neurodegenerative disease: an opportunity for therapeutic intervention
  6. Current potential diagnostic biomarkers of amyotrophic lateral sclerosis
  7. The neurobiological mechanisms of photoperiod impact on brain functions: a comprehensive review
  8. Accelerated biological brain aging in major depressive disorder
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