Startseite Dietary inflammatory index and neuropsychiatric disorders
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Dietary inflammatory index and neuropsychiatric disorders

  • Mahsa Golshani Nasab , Arash Heidari , Mohammadreza Sedighi , Narges Shakerian , Mona Mirbeyk , Amene Saghazadeh und Nima Rezaei ORCID logo EMAIL logo
Veröffentlicht/Copyright: 18. Juli 2023
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Abstract

Neuropsychiatric disorders (NPDs) are considered a potential threat to mental health. Inflammation predominantly plays a role in the pathophysiology of NPDs. Dietary patterns are widely postulated to be involved in the physiological response to inflammation. This review aims to discuss the literature on how dietary inflammatory index (DII) is related to inflammation and, consequently, NPDs. After comprehensive scrutiny in different databases, the articles that investigated the relation of DII score and various NPDs and psychological circumstances were included. The association between dietary patterns and mental disorders comprising depression, anxiety, and stress proved the role of a proinflammatory diet in these conditions’ exacerbation. Aging is another condition closely associated with DII. The impact of proinflammatory and anti-inflammatory diet on sleep quality indicated related disorders like sleep latency and day dysfunctions among the different populations are in relation with the high DII score. The potential effects of genetic backgrounds, dietary patterns, and the gut microbiome on DII are discussed as well. To plan preventive or therapeutic interventions considering the DII, these factors, especially genetic variations, should be considered as there is a growing body of literature indicating the role of personalized medicine in different NPDs. To the best of our knowledge, there is a limited number of RCTs on this subject, so future research should evaluate the causality via RCTs and look for therapeutic interventions with an eye on personalized medicine using information about DII in NPDs.


Corresponding author: Nima Rezaei, Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Dr. Qarib St, Keshavarz Blvd, Tehran 14194, Iran; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; and Network of Immunity in Infection, Malignancy and Autoimmunity, Universal Scientific Education and Research Network (USERN), Tehran, Iran, E-mail:
Mahsa Golshani Nasab, Arash Heidari, Mohammadreza Sedighi, and Narges Shakerian equally contributed to this article.
  1. Author contributions: M.G.N., A.H., M.S., and N.S. conceptualized the study and prepared the original draft. M.M. conceptualized the study, designed figures, and edited the manuscript. A.S. administered the project, conceptualized the study, and revised the manuscript. N.R. conceptualized the study, appraised the manuscript, and supervised the project.

  2. Research funding: None declared.

  3. Conflict of interest statement: The authors declare they have no conflicts of interest.

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Received: 2023-04-17
Accepted: 2023-06-24
Published Online: 2023-07-18
Published in Print: 2024-01-29

© 2023 Walter de Gruyter GmbH, Berlin/Boston

Heruntergeladen am 22.11.2025 von https://www.degruyterbrill.com/document/doi/10.1515/revneuro-2023-0047/html
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