Abstract
Mast cells are immunological cells that are diversely distributed in different parts of the body. Their role in various pathological conditions such as hypersensitivity, atherosclerosis, pulmonary hypertension, and male infertility has been reported by different scientists. Apart from these, a number of studies have shown their important role in pathogenesis of neuropathic pain of diverse aetiology. They have been found to release active mediators, primarily histamine and serotonin on degranulation in response to different stimuli including chemical, nerve damage, toxin or disease-related conditions. The mast cells stabilizer has shown pain attenuating effects by preventing degranulation of mast cells. Similarly, compound 48/80 (first dose 200 μg/100 g and after 6-h interval, second dose of 500 μg/100 g) caused the degranulation of the accumulated endoneurial histamine and 5-HT antagonists have shown pain relieving effects by attenuating the effects of histamine and serotonin, respectively. On the other hand, the mast cell degranulator compound 48/80 has shown dual action depending on its time of administration. The present review discusses the critical role of mast cells in the generation and maintenance of neuropathic pain in experimental models.
Acknowledgement
The authors are thankful to the Department of Pharmaceutical Sciences and Drug Research, Patiala, India, for support.
References
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Artikel in diesem Heft
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- Mild cognitive impairment in type 2 diabetes mellitus and related risk factors: a review
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- Microbiota abnormalities and the therapeutic potential of probiotics in the treatment of mood disorders
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- Mast cells in neuropathic pain: an increasing spectrum of their involvement in pathophysiology
- Revisiting nicotine’s role in the ageing brain and cognitive impairment
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Artikel in diesem Heft
- Frontmatter
- Adult hippocampal neurogenesis: an important target associated with antidepressant effects of exercise
- Factors underlying cognitive decline in old age and Alzheimer’s disease: the role of the hippocampus
- Mild cognitive impairment in type 2 diabetes mellitus and related risk factors: a review
- The use of mesenchymal stem cells (MSCs) for amyotrophic lateral sclerosis (ALS) therapy – a perspective on cell biological mechanisms
- Microbiota abnormalities and the therapeutic potential of probiotics in the treatment of mood disorders
- Pulsed magnetic field treatment as antineuropathic pain therapy
- Mast cells in neuropathic pain: an increasing spectrum of their involvement in pathophysiology
- Revisiting nicotine’s role in the ageing brain and cognitive impairment
- Status of essential elements in autism spectrum disorder: systematic review and meta-analysis
- Interactions between cannabis and schizophrenia in humans and rodents