Metal organic frameworks (MOFS) as non-viral carriers for DNA and RNA delivery: a review

References

Abdelhamid, H. Biointerface between ZIF-8 and biomolecules and their applications. Biointerface Res. Appl. Chem. 2021a, 11, 8283–8297.10.33263/BRIAC111.82838297Suche in Google Scholar

Abdelhamid, H. Zeolitic imidazolate frameworks (ZIF-8) for biomedical applications: a review. Curr. Med. Chem. 2021b, 28, 7023–7075; https://doi.org/10.2174/0929867328666210608143703.Suche in Google Scholar PubMed

Abdelhamid, H. N.; Dowaidar, M.; Hällbrink, M.; Langel, Ü. Gene delivery using cell penetrating peptides-zeolitic imidazolate frameworks. Microporous Mesoporous Mater. 2020a, 300, 110173; https://doi.org/10.1016/j.micromeso.2020.110173.Suche in Google Scholar

Abdelhamid, H. N.; Dowaidar, M.; Hällbrink, M.; Langel, Ü. Gene delivery using cell penetrating peptides-zeolitic imidazolate frameworks. Microporous Mesoporous Mater. 2020b, 300, 110173; https://doi.org/10.1016/j.micromeso.2020.110173.Suche in Google Scholar

Abdelhamid, H. N.; Dowaidar, M.; Langel, Ü. Carbonized chitosan encapsulated hierarchical porous zeolitic imidazolate frameworks nanoparticles for gene delivery. Microporous Mesoporous Mater. 2020c, 302, 110200; https://doi.org/10.1016/j.micromeso.2020.110200.Suche in Google Scholar

Alsaiari, S. K.; Patil, S.; Alyami, M.; Alamoudi, K. O.; Aleisa, F. A.; Merzaban, J. S.; Li, M.; Khashab, N. M. Endosomal escape and delivery of CRISPR/Cas9 genome editing machinery enabled by nanoscale zeolitic imidazolate framework. J. Am. Chem. Soc. 2018, 140(1), 143–146; https://doi.org/10.1021/jacs.7b11754.Suche in Google Scholar PubMed

Alyami, M. Z.; Alsaiari, S. K.; Li, Y.; Qutub, S. S.; Aleisa, F. A.; Sougrat, R.; Merzaban, J. S.; Khashab, N. M. Cell-type-specific CRISPR/Cas9 delivery by biomimetic metal organic frameworks. J. Am. Chem. Soc. 2020, 142(4), 1715–1720; https://doi.org/10.1021/jacs.9b11638.Suche in Google Scholar PubMed

An, H.; Li, M.; Gao, J.; Zhang, Z.; Ma, S.; Chen, Y. Incorporation of biomolecules in metal-organic frameworks for advanced applications. Coord. Chem. Rev. 2019, 384, 90–106; https://doi.org/10.1016/j.ccr.2019.01.001.Suche in Google Scholar

Anguela, X.; High, K. Entering the modern era of gene therapy. Annu. Rev. Med. 2019, 70, 273–288; https://doi.org/10.1146/annurev-med-012017-043332.Suche in Google Scholar PubMed

Baati, T.; Njim, L.; Neffati, F.; Kerkeni, A.; Bouttemi, M.; Gref, R.; Najjar, M. F.; Zakhama, A.; Couvreur, P.; Serre, C.; Horcajada, P. In depth analysis of the in vivo toxicity of nanoparticles of porous iron(iii) metal–organic frameworks. Chem. Sci. 2013, 4(4), 1597–1607; https://doi.org/10.1039/c3sc22116d.Suche in Google Scholar

Bhardwaj, T. A review on immobilization techniques of biosensors. Int. J. Eng. Res. Technol. 2014, 3, 294–298.Suche in Google Scholar

Blanco, E.; Shen, H.; Ferrari, M. Principles of nanoparticle design for overcoming biological barriers to drug delivery. Nat. Biotechnol. 2015, 33(9), 941–951; https://doi.org/10.1038/nbt.3330.Suche in Google Scholar

Cai, H.; Huang, Y.-L.; Li, D. Biological metal–organic frameworks: structures, host–guest chemistry and bio-applications. Coord. Chem. Rev. 2019, 378, 207–221; https://doi.org/10.1016/j.ccr.2017.12.003.Suche in Google Scholar

Cai, M.; Chen, G.; Qin, L.; Qu, C.; Dong, X.; Ni, J.; Yin, X. Metal organic frameworks as drug targeting delivery vehicles in the treatment of cancer. Pharmaceutics 2020, 12(3), 232; https://doi.org/10.3390/pharmaceutics12030232.Suche in Google Scholar

Cai, X.; Xie, Z.; Li, D.; Kassymova, M.; Zang, S.-Q.; Jiang, H.-L. Nano-sized metal-organic frameworks: synthesis and applications. Coord. Chem. Rev. 2020, 417, 213366; https://doi.org/10.1016/j.ccr.2020.213366.Suche in Google Scholar

Cochran, K. W.; Doull, J.; Mazur, M.; Dubois, K. Acute toxicity of zirconium, columbium, strontium, lanthanum, cesium, tantalum and yttrium. Arch. Ind. Hyg. Occup. Med. 1950, 1(6), 637–650.Suche in Google Scholar

Collard, W. T.; Yang, Y.; Kwok, K. Y.; Park, Y.; Rice, K. G. Biodistribution, metabolism, and in vivo gene expression of low molecular weight glycopeptide polyethylene glycol peptide DNA co-condensates. J. Pharmaceut. Sci. 2000, 89(4), 499–512; https://doi.org/10.1002/(sici)1520-6017(200004)89:4<499::aid-jps7>3.0.co;2-v.10.1002/(SICI)1520-6017(200004)89:4<499::AID-JPS7>3.0.CO;2-VSuche in Google Scholar

Cutler, J. I.; Auyeung, E.; Mirkin, C. A. Spherical nucleic acids. J. Am. Chem. Soc. 2012, 134(3), 1376–1391; https://doi.org/10.1021/ja209351u.Suche in Google Scholar

Chen, D.; Yang, D.; Dougherty, C. A.; Lu, W.; Wu, H.; He, X.; Cai, T.; Van Dort, M. E.; Ross, B. D.; Hong, H. In vivo targeting and positron emission tomography imaging of tumor with intrinsically radioactive metal–organic frameworks nanomaterials. ACS Nano 2017, 11(4), 4315–4327; https://doi.org/10.1021/acsnano.7b01530.Suche in Google Scholar

Chen, L.; Zheng, H.; Zhu, X.; Lin, Z.; Guo, L.; Qiu, B.; Chen, G.; Chen, Z.-N. Metal–organic frameworks-based biosensor for sequence-specific recognition of double-stranded DNA. Analyst 2013, 138(12), 3490–3493; https://doi.org/10.1039/c3an00426k.Suche in Google Scholar

Chen, X.; Zhuang, Y.; Rampal, N.; Hewitt, R.; Divitini, G.; O’Keefe, C. A.; Liu, X.; Whitaker, D. J.; Wills, J. W.; Jugdaohsingh, R.; Powell, J. J.; Yu, H.; Grey, C. P.; Scherman, O. A.; Fairen-Jimenez, D. Formulation of metal–organic framework-based drug carriers by controlled coordination of methoxy PEG phosphate: boosting colloidal stability and redispersibility. J. Am. Chem. Soc. 2021, 143(34), 13557–13572; https://doi.org/10.1021/jacs.1c03943.Suche in Google Scholar

Dash, P.; Read, M.; Fisher, K.; Howard, K.; Wolfert, M.; Oupicky, D.; Subr, V.; Strohalm, J.; Ulbrich, K.; Seymour, L. Decreased binding to proteins and cells of polymeric gene delivery vectors surface modified with a multivalent hydrophilic polymer and retargeting through attachment of transferrin. J. Biol. Chem. 2000, 275, 3793–3802; https://doi.org/10.1074/jbc.275.6.3793.Suche in Google Scholar

Davis, M. E. Non-viral gene delivery systems. Curr. Opin. Biotechnol. 2002, 13(2), 128–131; https://doi.org/10.1016/s0958-1669(02)00294-x.Suche in Google Scholar PubMed

Della Rocca, J.; Liu, D.; Lin, W. Nanoscale metal–organic frameworks for biomedical imaging and drug delivery. Acc. Chem. Res. 2011, 44(10), 957–968; https://doi.org/10.1021/ar200028a.Suche in Google Scholar PubMed PubMed Central

Dizaj, S. M.; Jafari, S.; Khosroushahi, A. Y. A sight on the current nanoparticle-based gene delivery vectors. Nanoscale Res. Lett. 2014, 9(1), 252; https://doi.org/10.1186/1556-276x-9-252.Suche in Google Scholar

Dong, S.; Chen, Q.; Li, W.; Jiang, Z.; Ma, J.; Gao, H. A dendritic catiomer with an MOF motif for the construction of safe and efficient gene delivery systems. J. Mater. Chem. B 2017, 5(42), 8322–8329; https://doi.org/10.1039/c7tb01966a.Suche in Google Scholar PubMed

Duan, W.; Zhao, Z.; An, H.; Zhang, Z.; Cheng, P.; Chen, Y.; Huang, H. State-of-the-art and prospects of biomolecules: incorporation in functional metal–organic frameworks. Top. Curr. Chem. 2019, 377(6), 34; https://doi.org/10.1007/s41061-019-0258-z.Suche in Google Scholar PubMed

Gao, X.; Yang, L.; Petros, J. A.; Marshall, F. F.; Simons, J. W.; Nie, S. In vivo molecular and cellular imaging with quantum dots. Curr. Opin. Biotechnol. 2005, 16(1), 63–72; https://doi.org/10.1016/j.copbio.2004.11.003.Suche in Google Scholar PubMed

García-Rendón, A.; Garibay-Escobar, A.; Guzmán, R.; Tejeda-Mansir, A. Chapter 6 – plasmid-DNA lipid nanovaccines: an innovative approach for a better world health. Lipid Nanocarriers Drug Target. 2018, 231–267; https://doi.org/10.1016/b978-0-12-813687-4.00006-2.Suche in Google Scholar

Giles-Mazón, E. A.; Germán-Ramos, I.; Romero-Romero, F.; Reinheimer, E.; Toscano, R. A.; Lopez, N.; Barrera-Díaz, C. E.; Varela-Guerrero, V.; Ballesteros-Rivas, M. F. Synthesis and characterization of a bio-MOF based on mixed adeninate/tricarboxylate ligands and zinc ions. Inorg. Chim. Acta. 2018, 469, 306–311; https://doi.org/10.1016/j.ica.2017.09.047.Suche in Google Scholar

Godbey, W. T.; Mikos, A. G. Recent progress in gene delivery using non-viral transfer complexes. J. Contr. Release 2001, 72(1), 115–125; https://doi.org/10.1016/s0168-3659(01)00267-x.Suche in Google Scholar PubMed

Gref, R.; Minamitake, Y.; Peracchia, M. T.; Trubetskoy, V.; Torchilin, V.; Langer, R. Biodegradable long-circulating polymeric nanospheres. Science 1994, 263(5153), 1600–1603; https://doi.org/10.1126/science.8128245.Suche in Google Scholar PubMed

Hardee, C. L.; Arévalo-Soliz, L. M.; Hornstein, B. D.; Zechiedrich, L. Advances in non-viral DNA vectors for gene therapy. Genes 2017, 8(2), 65.10.3390/genes8020065Suche in Google Scholar PubMed PubMed Central

Hidalgo, T.; Alonso-Nocelo, M.; Bouzo, B. L.; Reimondez-Troitiño, S.; Abuin-Redondo, C.; de la Fuente, M.; Horcajada, P. Biocompatible iron(iii) carboxylate metal–organic frameworks as promising RNA nanocarriers. Nanoscale 2020, 12(8), 4839–4845; https://doi.org/10.1039/c9nr08127e.Suche in Google Scholar PubMed

Hidalgo, T.; Giménez-Marqués, M.; Bellido, E.; Avila, J.; Asensio, M. C.; Salles, F.; Lozano, M. V.; Guillevic, M.; Simón-Vázquez, R.; González-Fernández, A.; Serre, C.; Alonso, M. J.; Horcajada, P. Chitosan-coated mesoporous MIL-100(Fe) nanoparticles as improved bio-compatible oral nanocarriers. Sci. Rep. 2017, 7(1), 43099; https://doi.org/10.1038/srep43099.Suche in Google Scholar PubMed PubMed Central

Hoop, M.; Walde, C. F.; Riccò, R.; Mushtaq, F.; Terzopoulou, A.; Chen, X.-Z.; deMello, A. J.; Doonan, C. J.; Falcaro, P.; Nelson, B. J.; Puigmartí-Luis, J.; Pané, S. Biocompatibility characteristics of the metal organic framework ZIF-8 for therapeutical applications. Appl. Mater. Today 2018, 11, 13–21; https://doi.org/10.1016/j.apmt.2017.12.014.Suche in Google Scholar

Horcajada, P.; Chalati, T.; Serre, C.; Gillet, B.; Sebrie, C.; Baati, T.; Eubank, J. F.; Heurtaux, D.; Clayette, P.; Kreuz, C.; Chang, J.-S.; Hwang, Y. K.; Marsaud, V.; Bories, P.-N.; Cynober, L.; Gil, S.; Férey, G.; Couvreur, P.; Gref, R. Porous metal–organic-framework nanoscale carriers as a potential platform for drug delivery and imaging. Nat. Mater. 2010, 9(2), 172–178; https://doi.org/10.1038/nmat2608.Suche in Google Scholar PubMed

Horcajada, P.; Gref, R.; Baati, T.; Allan, P. K.; Maurin, G.; Couvreur, P.; Férey, G.; Morris, R. E.; Serre, C. Metal–organic frameworks in biomedicine. Chem. Rev. 2012, 112(2), 1232–1268; https://doi.org/10.1021/cr200256v.Suche in Google Scholar PubMed

Hwang, E. T.; Gu, M. B. Enzyme stabilization by nano/microsized hybrid materials. Eng. Life Sci. 2013, 13(1), 49–61; https://doi.org/10.1002/elsc.201100225.Suche in Google Scholar

Ibrahim, M.; Sabouni, R.; Husseini, G. Anti-cancer drug delivery using metal organic frameworks (MOFs). Curr. Med. Chem. 2017, 24, 193–214; https://doi.org/10.2174/0929867323666160926151216.Suche in Google Scholar PubMed

Ikezoe, Y.; Washino, G.; Uemura, T.; Kitagawa, S.; Matsui, H. Autonomous motors of a metal–organic framework powered by reorganization of self-assembled peptides at interfaces. Nat. Mater. 2012, 11(12), 1081–1085; https://doi.org/10.1038/nmat3461.Suche in Google Scholar PubMed PubMed Central

Jokerst, J. V.; Lobovkina, T.; Zare, R. N.; Gambhir, S. S. Nanoparticle PEGylation for imaging and therapy. Nanomedicine (London, Engl.) 2011, 6(4), 715–728; https://doi.org/10.2217/nnm.11.19.Suche in Google Scholar PubMed PubMed Central

Kenry; Lim, C. T. Nanofiber technology: current status and emerging developments. Prog. Polym. Sci. 2017, 70, 1–17; https://doi.org/10.1016/j.progpolymsci.2017.03.002.Suche in Google Scholar

Khalil, A. M. The genome editing revolution: review. J. Genet. Eng. Biotechnol. 2020, 18(1), 68; https://doi.org/10.1186/s43141-020-00078-y.Suche in Google Scholar PubMed PubMed Central

Khan, I.; Saeed, K.; Khan, I. Nanoparticles: properties, applications and toxicities. Arab. J. Chem. 2019, 12(7), 908–931; https://doi.org/10.1016/j.arabjc.2017.05.011.Suche in Google Scholar

Kircheis, R.; Blessing, T.; Brunner, S.; Wightman, L.; Wagner, E. Tumor targeting with surface-shielded ligand–polycation DNA complexes. J. Contr. Release 2001, 72(1), 165–170; https://doi.org/10.1016/s0168-3659(01)00272-3.Suche in Google Scholar PubMed

Li, L.; Han, S.; Zhao, S.; Li, X.; Liu, B.; Liu, Y. Chitosan modified metal–organic frameworks as a promising carrier for oral drug delivery. RSC Adv. 2020, 10(73), 45130–45138; https://doi.org/10.1039/d0ra08459j.Suche in Google Scholar PubMed PubMed Central

Li, P.; Modica, J. A.; Howarth, A. J.; Vargas L, E.; Moghadam, P. Z.; Snurr, R. Q.; Mrksich, M.; Hupp, J. T.; Farha, O. K. Toward design rules for enzyme immobilization in hierarchical mesoporous metal-organic frameworks. Chem. 2016a, 1(1), 154–169; https://doi.org/10.1016/j.chempr.2016.05.001.Suche in Google Scholar

Li, P.; Moon, S.-Y.; Guelta, M. A.; Harvey, S. P.; Hupp, J. T.; Farha, O. K. Encapsulation of a nerve agent detoxifying enzyme by a mesoporous zirconium metal–organic framework engenders thermal and long-term stability. J. Am. Chem. Soc. 2016b, 138(26), 8052–8055; https://doi.org/10.1021/jacs.6b03673.Suche in Google Scholar PubMed

Li, Q.; Dong, H.; Yang, G.; Song, Y.; Mou, Y.; Ni, Y. Mouse tumor-bearing models as preclinical study platforms for oral squamous cell carcinoma. Front. Oncol. 2020, 10, 212; https://doi.org/10.3389/fonc.2020.00212.Suche in Google Scholar PubMed PubMed Central

Li, S.-Y.; Xie, B.-R.; Cheng, H.; Li, C.-X.; Zhang, M.-K.; Qiu, W.-X.; Liu, W.-L.; Wang, X.-S.; Zhang, X.-Z. A biomimetic theranostic O2-meter for cancer targeted photodynamic therapy and phosphorescence imaging. Biomaterials 2018, 151, 1–12; https://doi.org/10.1016/j.biomaterials.2017.10.021.Suche in Google Scholar PubMed

Li, Y.; Zhang, K.; Liu, P.; Chen, M.; Zhong, Y. L.; Ye, Q.; Wei, M.; Zhao, H.; Tang, Z. Encapsulation of plasmid DNA by nanoscale metal–organic frameworks for efficient gene transportation and expression. Adv. Mater. 2019, 31, 1901570; https://doi.org/10.1002/adma.201901570.Suche in Google Scholar PubMed

Lian, X.; Fang, Y.; Joseph, E.; Wang, Q.; Li, J.; Banerjee, S.; Lollar, C.; Wang, X.; Zhou, H.-C. Enzyme–MOF (metal–organic framework) composites. Chem. Soc. Rev. 2017, 46(11), 3386–3401; https://doi.org/10.1039/c7cs00058h.Suche in Google Scholar PubMed

Liang, K.; Ricco, R.; Doherty, C. M.; Styles, M. J.; Bell, S.; Kirby, N.; Mudie, S.; Haylock, D.; Hill, A. J.; Doonan, C. J.; Falcaro, P. Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules. Nat. Commun. 2015, 6(1), 7240; https://doi.org/10.1038/ncomms8240.Suche in Google Scholar PubMed PubMed Central

Liang, K.; Richardson, J. J.; Cui, J.; Caruso, F.; Doonan, C. J.; Falcaro, P. Metal–organic framework coatings as cytoprotective exoskeletons for living cells. Adv. Mater. 2016, 28(36), 7910–7914; https://doi.org/10.1002/adma.201602335.Suche in Google Scholar PubMed

Lin, G.; Zhang, Y.; Zhang, L.; Wang, J.; Tian, Y.; Cai, W.; Tang, S.; Chu, C.; Zhou, J.; Mi, P.; Chen, X.; Liu, G. Metal-organic frameworks nanoswitch: toward photo-controllable endo/lysosomal rupture and release for enhanced cancer RNA interference. Nano Res. 2020, 13(1), 238–245; https://doi.org/10.1007/s12274-019-2606-2.Suche in Google Scholar

Liu, B.; Hu, F.; Zhang, J.; Wang, C.; Li, L. A biomimetic coordination nanoplatform for controlled encapsulation and delivery of drug–gene combinations. Angew. Chem. Int. Ed. 2019, 58(26), 8804–8808; https://doi.org/10.1002/ange.201903417.Suche in Google Scholar

Liu, J.; Guo, Z.; Liang, K. Biocatalytic metal-organic framework-based artificial cells. Adv. Funct. Mater. 2019, 29(45), 1905321; https://doi.org/10.1002/adfm.201905321.Suche in Google Scholar

Mao, H.-Q.; Roy, K.; Troung-Le, V. L.; Janes, K. A.; Lin, K. Y.; Wang, Y.; August, J. T.; Leong, K. W. Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency. J. Contr. Release 2001, 70(3), 399–421; https://doi.org/10.1016/s0168-3659(00)00361-8.Suche in Google Scholar PubMed

Mehta, N.; Robbins, D. A.; Yiu, G. Ocular inflammation and treatment emergent adverse events in retinal gene therapy. Int. Ophthalmol. Clin. 2021, 61(3), 151–177; https://doi.org/10.1097/iio.0000000000000366.Suche in Google Scholar

Morris, W.; Briley, W. E.; Auyeung, E.; Cabezas, M. D.; Mirkin, C. A. Nucleic acid–metal organic framework (MOF) nanoparticle conjugates. J. Am. Chem. Soc. 2014, 136(20), 7261–7264; https://doi.org/10.1021/ja503215w.Suche in Google Scholar PubMed

Muñoz, A.; Costa, M. Elucidating the mechanisms of nickel compound uptake: a review of particulate and nano-nickel endocytosis and toxicity. Toxicol. Appl. Pharmacol. 2012, 260(1), 1–16; https://doi.org/10.1016/j.taap.2011.12.014.Suche in Google Scholar PubMed PubMed Central

Nadar, S. S.; Rathod, V. K. Encapsulation of lipase within metal-organic framework (MOF) with enhanced activity intensified under ultrasound. Enzym. Microb. Technol. 2018, 108, 11–20; https://doi.org/10.1016/j.enzmictec.2017.08.008.Suche in Google Scholar PubMed

Neri-Hipólito, J.; Lopez, N.; Reinheimer, E. W.; Mas-Hernández, E.; Barrera-Díaz, C. E.; Varela-Guerrero, V.; Ballesteros-Rivas, M. F. Dopamine (DA) detection in nanomolar concentration by 2,3-diaminophenazine (DAP) released from (DAP)@BioMOF-1 films. Polyhedron 2019, 169, 123–128; https://doi.org/10.1016/j.poly.2019.05.015.Suche in Google Scholar

Nimesh, S. 5 – theory and limitations to gene therapy. In Gene Therapy; Nimesh, S., Ed. Woodhead Publishing: Cambridge, United Kingdom, 2013; pp. 89–111.10.1533/9781908818645.89Suche in Google Scholar

Pan, Q.; Chen, T.-T.; Nie, C.; Yi, J.; Liu, C.; Hu, Y.; Chu, X. In situ synthesis of ultrathin ZIF-8 film coated MSNs for co-delivering Bcl-2 siRNA and doxorubicin to enhance chemothera-peutic efficacy in drug-resistant cancer cells. ACS Appl. Mater. Interfaces 2018, 10, 33070–33077; https://doi.org/10.1021/acsami.8b13393.Suche in Google Scholar PubMed

Peng, S.; Bie, B.; Sun, Y.; Liu, M.; Cong, H.; Zhou, W.; Xia, Y.; Tang, H.; Deng, H.; Zhou, X. Metal-organic frameworks for precise inclusion of single-stranded DNA and transfection in immune cells. Nat. Commun. 2018, 9(1), 1293; https://doi.org/10.1038/s41467-018-03650-w.Suche in Google Scholar PubMed PubMed Central

Poddar, A.; Conesa, J. J.; Liang, K.; Dhakal, S.; Reineck, P.; Bryant, G.; Pereiro, E.; Ricco, R.; Amenitsch, H.; Doonan, C.; Mulet, X.; Doherty, C. M.; Falcaro, P.; Shukla, R. Encapsulation, visualization and expression of genes with biomimetically mineralized zeolitic imidazolate framework-8 (ZIF-8). Small 2019, 15(36), 1902268; https://doi.org/10.1002/smll.201902268.Suche in Google Scholar PubMed

Poddar, A.; Pyreddy, S.; Carraro, F.; Dhakal, S.; Rassell, A.; Field, M. R.; Reddy, T. S.; Falcaro, P.; Doherty, C. M.; Shukla, R. ZIF-C for targeted RNA interference and CRISPR/Cas9 based gene editing in prostate cancer. Chem. Commun. 2020, 56(98), 15406–15409; https://doi.org/10.1039/d0cc06241c.Suche in Google Scholar PubMed

Pun, S. H.; Davis, M. E. Development of a nonviral gene delivery vehicle for systemic application. Bioconjugate Chem. 2002, 13(3), 630–639; https://doi.org/10.1021/bc0155768.Suche in Google Scholar PubMed

Qiu, G.-H.; Weng, Z.-H.; Hu, P.-P.; Duan, W.-J.; Xie, B.-P.; Sun, B.; Tang, X.-Y.; Chen, J.-X. Synchronous detection of ebolavirus conserved RNA sequences and ebolavirus-encoded miRNA-like fragment based on a zwitterionic copper (II) metal–organic framework. Talanta 2018, 180, 396–402; https://doi.org/10.1016/j.talanta.2017.12.045.Suche in Google Scholar PubMed

Rabiee, N.; Bagherzadeh, M.; Heidarian Haris, M.; Ghadiri, A. M.; Matloubi Moghaddam, F.; Fatahi, Y.; Dinarvand, R.; Jarahiyan, A.; Ahmadi, S.; Shokouhimehr, M. Polymer-coated NH2-UiO-66 for the codelivery of DOX/pCRISPR. ACS Appl. Mater. Interfaces 2021, 13(9), 10796–10811; https://doi.org/10.1021/acsami.1c01460.Suche in Google Scholar PubMed

Ramón-Azcón, J.; Ahadian, S.; Obregon, R.; Shiku, H.; Ramalingam, M.; Matsue, T. Applications of carbon nanotubes in stem cell research. J. Biomed. Nanotechnol. 2014, 10, 2539–2561; https://doi.org/10.1166/jbn.2014.1899.Suche in Google Scholar PubMed

Ringaci, A.; Yaremenko, A. V.; Shevchenko, K. G.; Zvereva, S. D.; Nikitin, M. P. Metal-organic frameworks for simultaneous gene and small molecule delivery in vitro and in vivo. Chem. Eng. J. 2021, 418, 129386; https://doi.org/10.1016/j.cej.2021.129386.Suche in Google Scholar

Shen, M.; Forghani, F.; Kong, X.; Liu, D.; Ye, X.; Chen, S.; Ding, T. Antibacterial applications of metal–organic frameworks and their composites. Compr. Rev. Food Sci. Food Saf. 2020, 19(4), 1397–1419; https://doi.org/10.1111/1541-4337.12515.Suche in Google Scholar PubMed

Simon-Yarza, T.; Mielcarek, A.; Couvreur, P.; Serre, C. Nanoparticles of metal-organic frameworks: on the road to in vivo efficacy in biomedicine. Adv. Mater. 2018, 30, 1707365; https://doi.org/10.1002/adma.201707365.Suche in Google Scholar PubMed

Somanathan, S.; Calcedo, R.; Wilson, J. Adenovirus-antibody complexes contributed to lethal systemic inflammation in a gene therapy trial. Mol. Ther. 2020, 28, 784–793; https://doi.org/10.1016/j.ymthe.2020.01.006.Suche in Google Scholar PubMed PubMed Central

Sources, S. O. o. t. P. o. F. A. a. N.; (ANS), a. t. F. Manganese ascorbate, manganese aspartate, manganese bisglycinate and manganese pidolate as sources of manganese added for nutritional purposes to food supplements. Eur. Food Saf. Auth. 2009, 1114, 1–23.Suche in Google Scholar

Stewart, M. P.; Sharei, A.; Ding, X.; Sahay, G.; Langer, R.; Jensen, K. F. In vitro and ex vivo strategies for intracellular delivery. Nature 2016, 538(7624), 183–192; https://doi.org/10.1038/nature19764.Suche in Google Scholar PubMed

Suk, J. S.; Xu, Q.; Kim, N.; Hanes, J.; Ensign, L. M. PEGylation as a strategy for improving nanoparticle-based drug and gene delivery. Adv. Drug Deliv. Rev. 2016, 99, 28–51; https://doi.org/10.1016/j.addr.2015.09.012.Suche in Google Scholar PubMed PubMed Central

Sun, C.-Y.; Qin, C.; Wang, X.-L.; Su, Z.-M. Metal-organic frameworks as potential drug delivery systems. Expert Opin. Drug Deliv. 2013, 10(1), 89–101; https://doi.org/10.1517/17425247.2013.741583.Suche in Google Scholar PubMed

Sun, H.; Li, Y.; Yu, S.; Liu, J. Metal-organic frameworks (MOFs) for biopreservation: from biomacromolecules, living organisms to biological devices. Nano Today 2020, 35, 100985; https://doi.org/10.1016/j.nantod.2020.100985.Suche in Google Scholar

Sun, P.; Li, Z.; Wang, J.; Gao, H.; Yang, X.; Wu, S.; Liu, D.; Chen, Q. Transcellular delivery of messenger RNA payloads by a cationic supramolecular MOF platform. Chem. Commun. 2018, 54(80), 11304–11307; https://doi.org/10.1039/c8cc07047d.Suche in Google Scholar PubMed

Sun, R. W.-Y.; Zhang, M.; Li, D.; Zhang, Z.-F.; Cai, H.; Li, M.; Xian, Y.-J.; Ng, S. W.; Wong, A. S.-T. Dinuclear gold(I) pyrrolidinedithiocarbamato complex: cytotoxic and antimigratory activities on cancer cells and the use of metal–organic framework. Chem. Eur J. 2015, 21(51), 18534–18538; https://doi.org/10.1002/chem.201503656.Suche in Google Scholar PubMed

Tamames-Tabar, C.; Cunha, D.; Imbuluzqueta, E.; Ragon, F.; Serre, C.; Blanco-Prieto, M. J.; Horcajada, P. Cytotoxicity of nanoscaled metal–organic frameworks. J. Mater. Chem. B 2014, 2(3), 262–271; https://doi.org/10.1039/c3tb20832j.Suche in Google Scholar PubMed

Teplensky, M. H.; Fantham, M.; Poudel, C.; Hockings, C.; Lu, M.; Guna, A.; Aragones-Anglada, M.; Moghadam, P. Z.; Li, P.; Farha, O. K.; Bernaldo de Quirós Fernández, S.; Richards, F. M.; Jodrell, D. I.; Kaminski Schierle, G.; Kaminski, C. F.; Fairen-Jimenez, D. A highly porous metal-organic framework system to deliver payloads for gene knockdown. Chem 2019, 5(11), 2926–2941; https://doi.org/10.1016/j.chempr.2019.08.015.Suche in Google Scholar

Varkouhi, A. K.; Scholte, M.; Storm, G.; Haisma, H. J. Endosomal escape pathways for delivery of biologicals. J. Contr. Release 2011, 151(3), 220–228; https://doi.org/10.1016/j.jconrel.2010.11.004.Suche in Google Scholar PubMed

Wang, H.; Chen, Y.; Wang, H.; Liu, X.; Zhou, X.; Wang, F. DNAzyme-loaded metal–organic frameworks (MOFs) for self-sufficient gene therapy. Angew. Chem. Int. Ed. 2019, 58(22), 7380–7384; https://doi.org/10.1002/ange.201902714.Suche in Google Scholar

Wang, S.; McGuirk, C. M.; Ross, M. B.; Wang, S.; Chen, P.; Xing, H.; Liu, Y.; Mirkin, C. A. General and direct method for preparing oligonucleotide-functionalized metal–organic framework nanoparticles. J. Am. Chem. Soc. 2017, 139(29), 9827–9830; https://doi.org/10.1021/jacs.7b05633.Suche in Google Scholar PubMed PubMed Central

Wang, Y.; Shahi, P. K.; Xie, R.; Zhang, H.; Abdeen, A. A.; Yodsanit, N.; Ma, Z.; Saha, K.; Pattnaik, B. R.; Gong, S. A pH-responsive silica–metal–organic framework hybrid nanoparticle for the delivery of hydrophilic drugs, nucleic acids, and CRISPR-Cas9 genome-editing machineries. J. Contr. Release 2020, 324, 194–203; https://doi.org/10.1016/j.jconrel.2020.04.052.Suche in Google Scholar PubMed PubMed Central

Wei, Y.-B.; Wang, M.-J.; Luo, D.; Huang, Y.-L.; Xie, M.; Lu, W.; Shu, X.; Li, D. Ultrasensitive and highly selective detection of formaldehyde via an adenine-based biological metal–organic framework. Mater. Chem. Front. 2021, 5(5), 2416–2424; https://doi.org/10.1039/d0qm01097a.Suche in Google Scholar

Yang, J.; Yang, Y.-W. Metal–organic frameworks for biomedical applications. Small 2020, 16(10), 1906846.10.1002/smll.201906846Suche in Google Scholar PubMed

Yin, H.; Kanasty, R. L.; Eltoukhy, A. A.; Vegas, A. J.; Dorkin, J. R.; Anderson, D. G. Non-viral vectors for gene-based therapy. Nat. Rev. Genet. 2014, 15(8), 541–555; https://doi.org/10.1038/nrg3763.Suche in Google Scholar PubMed

Zarghampoor, F.; Azarpira, N.; Khatami, S. R.; Behzad-Behbahani, A.; Foroughmand, A. M. Improved translation efficiency of therapeutic mRNA. Gene 2019, 707, 231–238; https://doi.org/10.1016/j.gene.2019.05.008.Suche in Google Scholar PubMed

Zhang, H.; Chen, W.; Gong, K.; Chen, J. Nanoscale zeolitic imidazolate framework-8 as efficient vehicles for enhanced delivery of CpG oligodeoxynucleotides. ACS Appl. Mater. Interfaces 2017a, 9(37), 31519–31525; https://doi.org/10.1021/acsami.7b09583.Suche in Google Scholar PubMed

Zhang, H.; Jiang, W.; Liu, R.; Zhang, J.; Zhang, D.; Li, Z.; Luan, Y. Rational design of metal organic framework nanocarrier-based codelivery system of doxorubicin hydrochloride/verapamil hydrochloride for overcoming multidrug resistance with efficient targeted cancer therapy. ACS Appl. Mater. Interfaces 2017b, 9(23), 19687–19697; https://doi.org/10.1021/acsami.7b05142.Suche in Google Scholar PubMed

Zhao, H.; Li, T.; Yao, C.; Gu, Z.; Liu, C.; Li, J.; Yang, D. Dual roles of metal–organic frameworks as nanocarriers for miRNA delivery and adjuvants for chemodynamic therapy. ACS Appl. Mater. Interfaces 2021, 13(5), 6034–6042; https://doi.org/10.1021/acsami.0c21006.Suche in Google Scholar PubMed

Zhao, J.; Lu, D.; Moya, S.; Yan, H.; Qiu, M.; Chen, J.; Wang, X.; Li, Y.; Pan, H.; Chen, G.; Wang, G. Bispecific T-cell engager (BiTE) immunotherapy of ovarian cancer based on MIL-88A MOF/MC gene delivery system. Appl. Mater. Today 2020, 20, 100701; https://doi.org/10.1016/j.apmt.2020.100701.Suche in Google Scholar

Zhao, M.; Wu, C.-D. Biomimetic activation of molecular oxygen with a combined metalloporphyrinic framework and co-catalyst platform. ChemCatChem 2017, 9(7), 1192–1196; https://doi.org/10.1002/cctc.201601606.Suche in Google Scholar

Zhuang, J.; Gong, H.; Zhou, J.; Zhang, Q.; Gao, W.; Fang, R. H.; Zhang, L. Targeted gene silencing in vivo by platelet membrane–coated metal-organic framework nanoparticles. Sci. Adv. 2020, 6(13), eaaz6108; https://doi.org/10.1126/sciadv.aaz6108.Suche in Google Scholar PubMed PubMed Central