Startseite Drug delivery and innovative pharmaceutical development in mimicking the red blood cell membrane
Artikel
Lizenziert
Nicht lizenziert Erfordert eine Authentifizierung

Drug delivery and innovative pharmaceutical development in mimicking the red blood cell membrane

  • Sumaira Naeem , Lik Voon Kiew , Chung Lip Yong , Yin Teo Yin und Misni Bin Misran EMAIL logo
Veröffentlicht/Copyright: 26. August 2015
Veröffentlichen auch Sie bei De Gruyter Brill

Abstract

Circulation half-life has become one of the major design considerations in nanoparticle drug delivery systems. By taking cues for designing long circulating carriers from natural entities such as red blood cells (RBCs) has been explored for many years. Among all the cellular carriers including leukocytes, fibroblasts, islets, and hepatocytes, RBCs offer several distinctive features. The present review underlines a discussion on the applications of different RBC carriers (RBC mimics) which can evade the body’s reticuloendothelial system overcoming many barriers such as size, shape, accelerated blood clearance, mechanical properties, control over particle characteristics, and surface chemistry. Bilayer membrane liposomes infusing phospholipids have long been synthesized to mimic bioconcave RBC carriers using the notion of stealth liposomes. This is not a comprehensive review; some illustrative examples are given on how they are currently obtained. A special attention is devoted to the RBC mimics from polymers, red cell membrane ghosts, and the red cell membrane enclosing polymeric cores as potential drug carriers. The present research reveals the achievement of RBC surface charge to accord with the immune system as a game of hide and seek in a much promising way in the light of its pharmaceutical applications.


Corresponding author: Misni Bin Misran, Faculty of Science, Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia, e-mail:

Acknowledgments

The authors would like to acknowledge and express sincere gratitude to the Ministry of Education, Malaysia, under the High Impact Research Grant (grant no. UM-MOHE:UM.C/625/1/HIR/MOHE//SC/09), University of Malaya Research Grant (grant no. FL001F-13 BIO) and Post Graduate Research Fund (grant no. PG123-2012B and grant no. PG094-2014A) for their financial support throughout this project. The authors would also like to acknowledge University of Malaya Bright Sparks Unit (Grant no: BSP/APP/0784/2012), which financially supported this work.

References

Abdelbary AA, AbouGhaly MH. Design and optimization of topical methotrexate loaded niosomes for enhanced management of psoriasis: application of Box-Behnken design, in-vitro evaluation and in-vivo skin deposition study. Int J Pharm 2015; 485: 235–243.10.1016/j.ijpharm.2015.03.020Suche in Google Scholar

Ahn J, Miura Y, Yamada N, Chida T, Liu X, Kim A, Sato R, Tsumura R, Koga Y, Yasunaga M. Antibody fragment-conjugated polymeric micelles incorporating platinum drugs for targeted therapy of pancreatic cancer. Biomaterials 2015; 39: 23–30.10.1016/j.biomaterials.2014.10.069Suche in Google Scholar

Albanese A, Tang PS, Chan WC. The effect of nanoparticle size, shape, and surface chemistry on biological systems. Annu Rev Biomed Eng 2012; 14: 1–16.10.1146/annurev-bioeng-071811-150124Suche in Google Scholar

Allen TM. Ligand-targeted therapeutics in anticancer therapy. Nat Rev Cancer 2002; 2: 750–763.10.1038/nrc903Suche in Google Scholar

Allen TM, Cullis PR. Drug delivery systems: entering the mainstream. Science 2004; 303: 1818–1822.10.1126/science.1095833Suche in Google Scholar

Alpar HO, Lewis DA. Therapeutic efficacy of asparaginase encapsulated in intact erythrocytes. Biochem Pharmacol 1985; 34: 257–261.10.1016/0006-2952(85)90133-9Suche in Google Scholar

Alpar H, Irwin W. Some unique applications of erythrocytes as carrier systems. Adv Biosci 1987; 67: 1–9.Suche in Google Scholar

Amoozgar Z, Yeo Y. Recent advances in stealth coating of nanoparticle drug delivery systems. WIREs Nanomed Nanobiotechnol 2012; 4: 219–233.10.1002/wnan.1157Suche in Google Scholar PubMed PubMed Central

Andreozzi P, Martinelli C, Carney RP, Carney TM, Stellacci F. Erythrocyte incubation as a method for free-dye presence determination in fluorescently labeled nanoparticles. Mol Pharm 2012; 10: 875–882.10.1021/mp300530cSuche in Google Scholar PubMed

Aryal S, Hu C-MJ, Fang RH, Dehaini D, Carpenter C, Zhang D-E, Zhang L. Erythrocyte membrane-cloaked polymeric nanoparticles for controlled drug loading and release. Nanomedicine 2013; 8: 1271–1280.10.2217/nnm.12.153Suche in Google Scholar PubMed

Ashe S, Nayak D, Tiwari G, Rauta PR, Nayak B. Development of liposome-encapsulated ketoconazole: formulation, characterisation and evaluation of pharmacological therapeutic efficacy. Micro Nano Lett 2015; 10: 126–129.10.1049/mnl.2014.0198Suche in Google Scholar

Bahmani B, Bacon D, Anvari B. Erythrocyte-derived photo-theranostic agents: hybrid nano-vesicles containing indocyanine green for near infrared imaging and therapeutic applications. Sci Rep 2013; 3: 2180.10.1038/srep02180Suche in Google Scholar

Baker RF. Entry of ferritin into human red cells during hypotonic haemolysis. Nature 1967; 215: 424–425.10.1038/215424a0Suche in Google Scholar

Bangham A, Standish MM, Watkins J. Diffusion of univalent ions across the lamellae of swollen phospholipids. J Mol Biol 1965; 13: 238–252.10.1016/S0022-2836(65)80093-6Suche in Google Scholar

Banz A, Cremel M, Rembert A, Godfrin Y. In situ targeting of dendritic cells by antigen-loaded red blood cells: a novel approach to cancer immunotherapy. Vaccine 2010; 28: 2965–2972.10.1016/j.vaccine.2010.02.013Suche in Google Scholar PubMed

Bao G, Mitragotri S, Tong S. Multifunctional nanoparticles for drug delivery and molecular imaging. Annu Rev Biomed Eng 2013; 15: 253–282.10.1146/annurev-bioeng-071812-152409Suche in Google Scholar PubMed PubMed Central

Bareford LM, Swaan PW. Endocytic mechanisms for targeted drug delivery. Adv Drug Del Rev 2007; 59: 748–758.10.1016/j.addr.2007.06.008Suche in Google Scholar PubMed PubMed Central

Bennett S, Mast N, Lavigne K, Skalla W, Banerjee S, Sargeant T, Stopek J. Hydrogel implants with varying degrees of crosslinking. US Patent 20,150,024,022, 2015.Suche in Google Scholar

Benns JM, Choi J-S, Mahato RI, Park J-S, Kim SW. pH-sensitive cationic polymer gene delivery vehicle: N-Ac-poly (L-histidine)-graft-poly (L-lysine) comb shaped polymer. Bioconjug Chem 2000; 11: 637–645.10.1021/bc0000177Suche in Google Scholar PubMed

Bhateria M, Rachumallu R, Singh R, Bhatta RS. Erythrocytes-based synthetic delivery systems: transition from conventional to novel engineering strategies. Expert Opin Drug Deliv 2014; 11: 1219–1236.10.1517/17425247.2014.927436Suche in Google Scholar PubMed

Bhattarai N, Gunn J, Zhang M. Chitosan-based hydrogels for controlled, localized drug delivery. Adv Drug Deliv Rev 2010; 62: 83–99.10.1016/j.addr.2009.07.019Suche in Google Scholar PubMed

Boyer C, Whittaker MR, Bulmus V, Liu J, Davis TP. The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine applications. NPG Asia Mater 2010; 2: 23–30.10.1038/asiamat.2010.6Suche in Google Scholar

Brannon-Peppas L. Recent advances on the use of biodegradable microparticles and nanoparticles in controlled drug delivery. Int J Pharm 1995; 116: 1–9.10.1016/0378-5173(94)00324-XSuche in Google Scholar

Bretscher MS. Phosphatidyl-ethanolamine: differential labelling in intact cells and cell ghosts of human erythrocytes by a membrane-impermeable reagent. J Mol Biol 1972; 71: 523–528.10.1016/S0022-2836(72)80020-2Suche in Google Scholar

Brigger I, Dubernet C, Couvreur P. Nanoparticles in cancer therapy and diagnosis. Adv Drug Deliv Rev 2002; 54: 631–651.10.1016/S0169-409X(02)00044-3Suche in Google Scholar

Broom OJ, Zhang Y, Oldenborg P-A, Massoumi R, Sjölander A. CD47 regulates collagen I-induced cyclooxygenase-2 expression and intestinal epithelial cell migration. PloS One 2009; 4: e6371.10.1371/journal.pone.0006371Suche in Google Scholar PubMed PubMed Central

Cao Z, Yu Q, Xue H, Cheng G, Jiang S. Nanoparticles for drug delivery prepared from amphiphilic PLGA zwitterionic block copolymers with sharp contrast in polarity between two blocks. Angew Chem 2010; 122: 3859–3864.10.1002/ange.200907079Suche in Google Scholar

Champion JA, Mitragotri S. Role of target geometry in phagocytosis. Proc Natl Acad Sci USA 2006; 103: 4930–4934.10.1073/pnas.0600997103Suche in Google Scholar PubMed PubMed Central

Chaudhary S, Garg T, Rath G, Murthy RR, Goyal AK. Enhancing the bioavailability of mebendazole by integrating the principles solid dispersion and nanocrystal techniques, for safe and effective management of human echinococcosis. Artif Cells Nanomed Biotechnol 2015; 1–6.10.3109/21691401.2014.1000493Suche in Google Scholar PubMed

Chu Z, Dreiss CA, Feng Y. Smart wormlike micelles. Chem Soc Rev 2013; 42: 7174–7203.10.1039/c3cs35490cSuche in Google Scholar PubMed

Clawson C, Ton L, Aryal S, Fu V, Esener S, Zhang L. Synthesis and characterization of lipid-polymer hybrid nanoparticles with pH-triggered poly (ethylene glycol) shedding. Langmuir 2011; 27: 10556–10561.10.1021/la202123eSuche in Google Scholar PubMed PubMed Central

Cole MA, Voelcker NH, Thissen H, Griesser HJ. Stimuli-responsive interfaces and systems for the control of protein-surface and cell-surface interactions. Biomaterials 2009; 30: 1827–1850.10.1016/j.biomaterials.2008.12.026Suche in Google Scholar PubMed

d’Angelo I, Conte C, Miro A, Quaglia F, Ungaro F. Pulmonary drug delivery: a role for polymeric nanoparticles? Curr Topics Med Chem 2015; 15: 386–400.10.2174/1568026615666150108123256Suche in Google Scholar PubMed

Davis ME. Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat Rev Drug Discov 2008; 7: 771–782.10.1038/nrd2614Suche in Google Scholar PubMed

Davies A, Simmons DL, Hale G, Harrison RA, Tighe H, Lachmann P, Waldmann H. CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells. J Exp Med 1989; 170: 637–654.10.1084/jem.170.3.637Suche in Google Scholar PubMed PubMed Central

Discher DE, Eisenberg A. Polymer vesicles. Science 2002; 297: 967–973.10.1126/science.1074972Suche in Google Scholar PubMed

Discher D, Mohandas N, Evans E. Molecular maps of red cell deformation: hidden elasticity and in situ connectivity. Science 1994; 266: 1032–1035.10.1126/science.7973655Suche in Google Scholar PubMed

Doshi N, Zahr AS, Bhaskar S, Lahann J, Mitragotri S. Red blood cell-mimicking synthetic biomaterial particles. Proc Natl Acad Sci 2009; 106: 21495–21499.10.1073/pnas.0907127106Suche in Google Scholar PubMed PubMed Central

Drummond DC, Meyer O, Hong K, Kirpotin DB, Papahadjopoulos D. Optimizing liposomes for delivery of chemotherapeutic agents to solid tumors. Pharmacol Rev 1999; 51: 691–744.Suche in Google Scholar

Dufresne M-H, Garrec DL, Sant V, Leroux J-C, Ranger M. Preparation and characterization of water-soluble pH-sensitive nanocarriers for drug delivery. Int J Pharm 2004; 277: 81–90.10.1016/j.ijpharm.2003.07.014Suche in Google Scholar PubMed

Duncan R. Polymer conjugates as anticancer nanomedicines. Nat Rev Cancer 2006; 6: 688–701.10.1038/nrc1958Suche in Google Scholar PubMed

Dyondi D, Sarkar A, Banerjee R. Joint surface-active phospholipid-mimetic liposomes for intra-articular delivery of Paclitaxel. J Biomed Nanotechnol 2015; 11: 1225–1235.10.1166/jbn.2015.2061Suche in Google Scholar PubMed

Edidin M. Lipids on the frontier: a century of cell-membrane bilayers. Nat Rev Mol Cell Biol 2003; 4: 414–418.10.1038/nrm1102Suche in Google Scholar PubMed

Eichler H, Gasic S, Bauer K, Korn A, Bacher S. In vivo clearance of antibody-sensitized human drug carrier erythrocytes. Clin Pharmacol Ther 1986; 40: 300–303.10.1038/clpt.1986.180Suche in Google Scholar PubMed

Evans DF, Wennerström H. The colloidal domain: where physics, chemistry, biology, and technology meet. Weinheim, Germany: Wiley-Vch, 1999.Suche in Google Scholar

Fan W, Yan W, Xu Z, Ni H. Erythrocytes load of low molecular weight chitosan nanoparticles as a potential vascular drug delivery system. Colloids Surf B Biointerfaces 2012; 95: 258–265.10.1016/j.colsurfb.2012.03.006Suche in Google Scholar PubMed

Fang RH, Hu C-MJ, Luk BT, Gao W, Copp JA, Tai Y, O’Connor DE, Zhang L. Cancer cell membrane-coated nanoparticles for anticancer vaccination and drug delivery. Nano Lett 2014; 14: 2181–2188.10.1021/nl500618uSuche in Google Scholar PubMed PubMed Central

Fearon DT. Regulation of the amplification C3 convertase of human complement by an inhibitory protein isolated from human erythrocyte membrane. Proc Natl Acad Sci 1979; 76: 5867–5871.10.1073/pnas.76.11.5867Suche in Google Scholar PubMed PubMed Central

Felnerova D, Viret J-F, Glück R, Moser C. Liposomes and virosomes as delivery systems for antigens, nucleic acids and drugs. Curr Opin Biotechnol 2004; 15: 518–529.10.1016/j.copbio.2004.10.005Suche in Google Scholar PubMed

Franssen EJ, Koiter J, Kuipers CA, Bruins AP, Moolenaar F, De Zeeuw D, Kruizinga WH, Kellogg RM, Meijer DK. Low-molecular-weight proteins as carriers for renal drug targeting. Preparation of drug-protein conjugates and drug-spacer derivatives and their catabolism in renal cortex homogenates and lysosomal lysates. J Med Chem 1992; 35: 1246–1259.10.1021/jm00085a012Suche in Google Scholar PubMed

Freeling JP, Koehn J, Shu C, Sun J, Ho RJ. Anti-HIV drug-combination nanoparticles enhance plasma drug exposure duration as well as triple-drug combination levels in cells within lymph nodes and blood in primates. AIDS Res Hum Retroviruses 2015; 31: 107–114.10.1089/aid.2014.0210Suche in Google Scholar PubMed PubMed Central

Fu Q, Lv P, Chen Z, Ni D, Zhang L, Yue H, Yue Z, Wei W, Ma G-H. Programmed co-delivery of paclitaxel and doxorubicin boosted by camouflaging with erythrocyte membrane. Nanoscale 2015; 7: 4020–4030.10.1039/C4NR07027ESuche in Google Scholar PubMed

Fujita Y, Kuwano K, Ochiya T. Development of small RNA delivery systems for lung cancer therapy. Int J Mol Sci 2015; 16: 5254–5270.10.3390/ijms16035254Suche in Google Scholar PubMed PubMed Central

Fung Y, Cowin S. Biomechanics: mechanical properties of living tissues. J Appl Mech 1994; 61: 1007.10.1115/1.2901550Suche in Google Scholar

Ganta S, Devalapally H, Shahiwala A, Amiji M. A review of stimuli-responsive nanocarriers for drug and gene delivery. J Control Rel 2008; 126: 187–204.10.1016/j.jconrel.2007.12.017Suche in Google Scholar PubMed

Ganta S, Singh A, Kulkarni P, Keeler AW, Piroyan A, Sawant RR, Patel NR, Davis B, Ferris C, O’Neal S. Zamboni W, Amiji MM, Coleman TP. EGFR targeted theranostic nanoemulsion for image-guided ovarian cancer therapy. Pharm Res 2015; 35: 2753–2763.10.1007/s11095-015-1660-zSuche in Google Scholar PubMed PubMed Central

Gao W, Zhang L. Engineering red blood cell membrane-coated nanoparticles for broad biomedical applications. AIChE J 2015; 61: 738–746.10.1002/aic.14735Suche in Google Scholar

Gao W, Langer R, Farokhzad OC. Poly (ethylene glycol) with observable shedding. Angew Chem Int Ed 2010; 49: 6567–6571.10.1002/anie.201001868Suche in Google Scholar PubMed PubMed Central

Gao Y, Li X, Hong L, Liu G. Mesogen-driven formation of triblock copolymer cylindrical micelles. Macromolecules 2012; 45: 1321–1330.10.1021/ma202084mSuche in Google Scholar

Garín M-I, López R-M, Sanz S, Pinilla M, Luque J. Erythrocytes as carriers for recombinant human erythropoietin. Pharmaceut Res 1996; 13: 869–874.10.1023/A:1016049027661Suche in Google Scholar

Gates BD, Xu Q, Stewart M, Ryan D, Willson CG, Whitesides GM. New approaches to nanofabrication: molding, printing, and other techniques. Chem Rev 2005; 105: 1171–1196.10.1021/cr030076oSuche in Google Scholar PubMed

Geng Y, Dalhaimer P, Cai S, Tsai R, Tewari M, Minko T, Discher DE. Shape effects of filaments versus spherical particles in flow and drug delivery. Nat Nanotechnol 2007; 2: 249–255.10.1038/nnano.2007.70Suche in Google Scholar PubMed PubMed Central

Gomez-Hens A, Fernandez-Romero J. Analytical methods for the control of liposomal delivery systems. Trends Anal Chem 2006; 25: 167–178.10.1016/j.trac.2005.07.006Suche in Google Scholar

Gordesky SE, Marinetti G, Love R. The reaction of chemical probes with the erythrocyte membrane. J Membr Biol 1975; 20: 111–132.10.1007/BF01870631Suche in Google Scholar PubMed

Gordon J, Kazemian H, Rohani S. MIL-53 (Fe), MIL-101, and SBA-15 porous materials: potential platforms for drug delivery. Mater Sci Eng C 2015; 47: 172–179.10.1016/j.msec.2014.11.046Suche in Google Scholar

Grebowski J, Kazmierska P, Krokosz A. Fullerenols as a new therapeutic approach in nanomedicine. Biomed Res Int 2013a; 2013: 751913.10.1155/2013/751913Suche in Google Scholar

Grebowski J, Krokosz A, Puchala M. Fullerenol C60 (OH)36 could associate to band 3 protein of human erythrocyte membranes. Biochimica Biophysica Acta Biomembr 2013b; 1828: 2007–2014.10.1016/j.bbamem.2013.05.009Suche in Google Scholar

Grumezescu AM, Andronescu E, Oprea AE, Holban AM, Socol G, Grumezescu V, Chifiriuc MC, Iordache F, Maniu H. MAPLE fabricated magnetite@Melissa officinalis and poly lactic acid: chitosan coated surfaces with anti-staphylococcal properties. J Sol-Gel Sci Technol 2015; 73: 612–619.10.1007/s10971-014-3558-3Suche in Google Scholar

Gui R, Wang Y, Sun J. Encapsulating magnetic and fluorescent mesoporous silica into thermosensitive chitosan microspheres for cell imaging and controlled drug release in vitro. Colloids Surf B Biointerfaces 2014; 113: 1–9.10.1016/j.colsurfb.2013.08.015Suche in Google Scholar

Gupta N, Patel B, Ahsan F. Nano-engineered erythrocyte ghosts as inhalational carriers for delivery of fasudil: preparation and characterization. Pharm Res 2014; 31: 1553–1565.10.1007/s11095-013-1261-7Suche in Google Scholar

Hajizade A, Ebrahimi F, Salmanian A-H, Arpanae A, Amani J. Nanoparticles in vaccine development. J Appl Biotechnol Rep 2015; 1: 125–134.Suche in Google Scholar

Hamidi M, Tajerzadeh H. Carrier erythrocytes: an overview. Drug Deliv 2003; 10: 9–20.10.1080/713840329Suche in Google Scholar

Hans M, Lowman A. Biodegradable nanoparticles for drug delivery and targeting. Curr Opin Solid State Mater Sci 2002; 6: 319–327.10.1016/S1359-0286(02)00117-1Suche in Google Scholar

He H, Li Y, Jia X-R, Du J, Ying X, Lu W-L, Lou J-N, Wei Y. PEGylated poly(amidoamine) dendrimer-based dual-targeting carrier for treating brain tumors. Biomaterials 2011; 32: 478–487.10.1016/j.biomaterials.2010.09.002Suche in Google Scholar PubMed

He X, Li L, Su H, Zhou D, Song H, Wang L, Jiang X. Poly(ethylene glycol)-block-poly(ε-caprolactone) – and phospholipid-based stealth nanoparticles with enhanced therapeutic efficacy on murine breast cancer by improved intracellular drug delivery. Int J Nanomed 2015; 10: 1791.Suche in Google Scholar

Holguin M, Fredrick L, Bernshaw N, Wilcox L, Parker C. Isolation and characterization of a membrane protein from normal human erythrocytes that inhibits reactive lysis of the erythrocytes of paroxysmal nocturnal hemoglobinuria. J Clin Invest 1989; 84: 7.10.1172/JCI114172Suche in Google Scholar PubMed PubMed Central

Hosny KM, Banjar ZM, Hariri AH, Hassan AH. Solid lipid nanoparticles loaded with iron to overcome barriers for treatment of iron deficiency anemia. Drug Des Devel Ther 2015; 9: 313.10.2147/DDDT.S77702Suche in Google Scholar PubMed PubMed Central

Hu C-MJ, Zhang L, Aryal S, Cheung C, Fang RH, Zhang L. Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform. Proc Natl Acad Sci 2011; 108: 10980–10985.10.1073/pnas.1106634108Suche in Google Scholar PubMed PubMed Central

Hu CMJ, Fang RH, Zhang L. Erythrocyte-inspired delivery systems. Adv Healthc Mater 2012; 1: 537–547.10.1002/adhm.201200138Suche in Google Scholar PubMed

Iida K, Iwasaki T. Tsunamis: their science and engineering. Proceedings of the International Tsunami Symposium, 1981 IUGG Tsunami Commission, May 1981, Sendai-Ofunato-Kamaishi, Japan: D Reidel Pub Co., 1983.Suche in Google Scholar

Immordino ML, Dosio F, Cattel L. Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential. Int J Nanomed 2006; 1: 297.Suche in Google Scholar

Inai M, Yamauchi M, Honda N, Hazama H, Tachikawa S, Nakamura H, Nishida T, Yasuda H, Kaneda Y, Awazu K. Photodynamic therapy using hemagglutinating virus of Japan envelope (HVJ-E): a novel therapeutic approach for the treatment of hormone antagonistic prostate cancer. Proc. SPIE 2015; 9308: 930814.Suche in Google Scholar

Ishida T, Harada M, Wang XY, Ichihara M, Irimura K, Kiwada H. Accelerated blood clearance of PEGylated liposomes following preceding liposome injection: effects of lipid dose and PEG surface-density and chain length of the first-dose liposomes. J Control Release 2005; 105: 305–317.10.1016/j.jconrel.2005.04.003Suche in Google Scholar PubMed

Ishida T, Kashima S, Kiwada H. The contribution of phagocytic activity of liver macrophages to the accelerated blood clearance (ABC) phenomenon of PEGylated liposomes in rats. J Control Release 2008; 126: 162–165.10.1016/j.jconrel.2007.11.009Suche in Google Scholar PubMed

Jain S, Jain N. Engineered erythrocytes as a drug delivery system. Indian J Pharm Sci 1997; 59:275.Suche in Google Scholar

Jain S, Bates FS. On the origins of morphological complexity in block copolymer surfactants. Science 2003; 300: 460–464.10.1126/science.1082193Suche in Google Scholar PubMed

Jin H,Liu X, Gui R, Wang Z. Facile synthesis of gold nanorods/hydrogels core/shell nanospheres for pH and near-infrared-light induced release of 5-fluorouracil and chemo-photothermal therapy. Colloids Surf B Biointerfaces 2015; 128: 498–505.10.1016/j.colsurfb.2015.02.049Suche in Google Scholar PubMed

Johnson R, Lancaster R, Ku T. Antimicrobial agents. In: Kaye AD, Kaye AM, Urman RD, editors. Essentials of pharmacology for anesthesia, pain medicine, and critical care. USA: Springer, 2015: 525–547.Suche in Google Scholar

Jokerst JV, Lobovkina T, Zare RN, Gambhir SS. Nanoparticle PEGylation for imaging and therapy. Nanomedicine 2011; 6: 715–728.10.2217/nnm.11.19Suche in Google Scholar PubMed PubMed Central

Kanapathipillai M, Brock A, Ingber DE. Nanoparticle targeting of anti-cancer drugs that alter intracellular signaling or influence the tumor microenvironment. Adv Drug Deliv Rev 2014; 79: 107–118.10.1016/j.addr.2014.05.005Suche in Google Scholar PubMed

Kanzarkar M, Pathak PP, Vaidya M, Brumlik C, Choudhury A. Oral insulin-delivery system for diabetes mellitus. Pharm Patent Anal 2015; 4: 29–36.10.4155/ppa.14.53Suche in Google Scholar PubMed

Kaoui B, Biros G, Misbah C. Why do red blood cells have asymmetric shapes even in a symmetric flow? Phys Rev Lett 2009; 103: 188101.10.1103/PhysRevLett.103.188101Suche in Google Scholar PubMed

Karavas E, Georgarakis E, Sigalas MP, Avgoustakis K, Bikiaris D. Investigation of the release mechanism of a sparingly water-soluble drug from solid dispersions in hydrophilic carriers based on physical state of drug, particle size distribution and drug-polymer interactions. Eur J Pharm Biopharm 2007; 66: 334–347.10.1016/j.ejpb.2006.11.020Suche in Google Scholar PubMed

Karr JC, Lauretta J. In vitro activity of calcium sulfate and hydroxyapatite antifungal disks loaded with amphotericin B or voriconazole in consideration for adjunctive osteomyelitis management. J Am Podiatr Med Assoc 2015.10.7547/12-113.1Suche in Google Scholar PubMed

Keefe AJ, Jiang S. Poly(zwitterionic) protein conjugates offer increased stability without sacrificing binding affinity or bioactivity. Nat Chem 2012; 4: 59–63.10.1038/nchem.1213Suche in Google Scholar PubMed PubMed Central

Kevin N. Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles. Nanoscale 2013; 5: 8884–8888.10.1039/c3nr03064dSuche in Google Scholar PubMed PubMed Central

Kim TH, Mount CW, Dulken BW, Ramos J, Fu CJ, Khant HA, Chiu W, Gombotz WR, Pun SH. Filamentous, mixed micelles of triblock copolymers enhance tumor localization of indocyanine green in a murine xenograft model. Mol Pharm 2011; 9: 135–143.10.1021/mp200381cSuche in Google Scholar PubMed PubMed Central

Kirch J, Guenther M, Doshi N, Schaefer UF, Schneider M, Mitragotri S, Lehr C-M. Mucociliary clearance of micro-and nanoparticles is independent of size, shape and charge – an ex vivo and in silico approach. J Control Release 2012; 159: 128–134.10.1016/j.jconrel.2011.12.015Suche in Google Scholar PubMed

Knop K, Hoogenboom R, Fischer D, Schubert US. Poly (ethylene glycol) in drug delivery: pros and cons as well as potential alternatives. Angew Chem Int Ed 2010; 49: 6288–6308.10.1002/anie.200902672Suche in Google Scholar PubMed

Kong M, Hou L, Wang J, Feng C, Liu Y, Cheng X, Chen X. Enhanced transdermal lymphatic drug delivery of hyaluronic acid modified transfersomes for tumor metastasis therapy. Chem Commun 2015; 51: 1453–1456.10.1039/C4CC08746ASuche in Google Scholar

Kostić IT, Ilić VL, Bukara KM, Mojsilović SB, Durić ZŽ, Draškovič P, Bugarski BM. Flow cytometric determination of osmotic behaviour of animal erythrocytes toward their engineering for drug delivery. Hem Ind 2015; 69: 67–76.10.2298/HEMIND140124021KSuche in Google Scholar

Kravtzoff R, Ropars C, Laguerre M, Muh J, Chassaigne M. Erythrocytes as carriers for L-asparaginase. Methodological and mouse in-vivo studies. J Pharm Pharmacol 1990; 42: 473–476.10.1111/j.2042-7158.1990.tb06598.xSuche in Google Scholar

Krokosz A, Grebowski J, Rodacka A, Pasternak B, Puchala M. The effect of fullerenol C60 (OH)30 on the alcohol dehydrogenase activity irradiated with X-rays. Radiat Phys Chem 2014; 97: 102–106.10.1016/j.radphyschem.2013.11.009Suche in Google Scholar

Kumar BS, Bhat KI. In-vitro cytotoxic activity studies of clitoria ternatea linn flower extracts. Int J Pharma Sci Rev Res 2011; 6: 120–121.Suche in Google Scholar

Langer R. Drug delivery and targeting. Nature 1998; 392(Suppl): 5–10.10.1038/32020Suche in Google Scholar

Lee CC, MacKay JA, Fréchet JM, Szoka FC. Designing dendrimers for biological applications. Nat Biotechnol 2005; 23: 1517–1526.10.1038/nbt1171Suche in Google Scholar

Lejeune A, Moorjani M, Gicquaud C, Lacroix J, Poyet P, Gaudreault R. Nanoerythrosome, a new derivative of erythrocyte ghost: preparation and antineoplastic potential as drug carrier for daunorubicin. Anticancer Res 1993; 14: 915–919.Suche in Google Scholar

Lejeune FJ, Rüegg C, Liénard D. Clinical applications of TNF-α in cancer. Curr Opin Immunol 1998; 10: 573–580.10.1016/S0952-7915(98)80226-4Suche in Google Scholar

Lewis DA, Alpar HO. Therapeutic possibilities of drugs encapsulated in erythrocytes. Int J Pharm 1984; 22: 137–146.10.1016/0378-5173(84)90017-6Suche in Google Scholar

Li N, Zhao Q, Shu C, Ma X, Li R, Shen H, Zhong W. Targeted killing of cancer cells in vivo and in vitro with IGF-IR antibody-directed carbon nanohorns based drug delivery. Int J Pharm 2015; 478: 644–654.10.1016/j.ijpharm.2014.12.015Suche in Google Scholar PubMed

Liu J, Wang Z, Wu K, Li J, Chen W, Shen Y, Guo S. Paclitaxel or 5-fluorouracil/esophageal stent combinations as a novel approach for the treatment of esophageal cancer. Biomaterials 2015; 53: 592–599.10.1016/j.biomaterials.2015.03.009Suche in Google Scholar PubMed

Luan J, Zheng F, Yang X, Yu A, Zhai G. Nanostructured lipid carriers for oral delivery of baicalin: in vitro and in vivo evaluation. Colloids Surf A Physicochem Eng Aspects 2015; 466: 154–159.10.1016/j.colsurfa.2014.11.015Suche in Google Scholar

Luk BT, Hu C-MJ, Fang RH, Dehaini D, Carpenter C, Gao W, Zhang L. Interfacial interactions between natural RBC membranes and synthetic polymeric nanoparticles. Nanoscale 2014; 6: 2730–2737.10.1039/C3NR06371BSuche in Google Scholar PubMed PubMed Central

Lynch WE, Sartiano GP, Ghaffar A. Erythrocytes as carriers of chemotherapeutic agents for targeting the reticuloendothelial system. Am J Hematol 1980; 9: 249–259.10.1002/ajh.2830090303Suche in Google Scholar PubMed

Magnani M, Rossi L, Fraternale A, Bianchi M, Antonelli A, Crinelli R, Chiarantini L. Erythrocyte-mediated delivery of drugs, peptides and modified oligonucleotides. Gene Ther 2002; 9: 749–751.10.1038/sj.gt.3301758Suche in Google Scholar PubMed

Maleknia L, Majdi ZR. Electrospinning of Gelatin nanofiber for biomedical application. Oriental J Chem 2014; 30: 2043–2048.10.13005/ojc/300470Suche in Google Scholar

McNamara RK, Jandacek R, Rider T, Tso P, Dwivedi Y, Pandey GN. Selective deficits in erythrocyte docosahexaenoic acid composition in adult patients with bipolar disorder and major depressive disorder. J Affective Disord 2010; 126: 303–311.10.1016/j.jad.2010.03.015Suche in Google Scholar PubMed PubMed Central

Merkel TJ, Jones SW, Herlihy KP, Kersey FR, Shields AR, Napier M, Luft JC, Wu H, Zamboni WC, Wang AZ, et al. Using mechanobiological mimicry of red blood cells to extend circulation times of hydrogel microparticles. Proc Natl Acad Sci USA 2011; 108: 586–591.10.1073/pnas.1010013108Suche in Google Scholar PubMed PubMed Central

Metaxa A-F, Efthimiadou EK, Kordas G. Cellulose-based drug carriers for cancer therapy: cytotoxic evaluation in cancer and healthy cells. Mater Lett 2014; 132: 432–435.10.1016/j.matlet.2014.06.134Suche in Google Scholar

Millan CG, Marinero ML, Castaneda AZ, Lanao JM. Drug, enzyme and peptide delivery using erythrocytes as carriers. J Control Release 2004; 95: 27–49.10.1016/j.jconrel.2003.11.018Suche in Google Scholar PubMed

Mitragotri S, Lahann J. Physical approaches to biomaterial design. Nat Mater 2009; 8: 15–23.10.1038/nmat2344Suche in Google Scholar PubMed PubMed Central

Mitragotri S, Stayton P. Organic nanoparticles for drug delivery and imaging. MRS Bull 2014; 39: 219–223.10.1557/mrs.2014.11Suche in Google Scholar

Mock DM, Widness JA, Strauss RG, Franco RS. Posttransfusion red blood cell (RBC) survival determined using biotin-labeled RBCs has distinct advantages over labeling with 51Cr. Transfusion 2012; 52: 1596.10.1111/j.1537-2995.2012.03588.xSuche in Google Scholar PubMed PubMed Central

Moghimi SM, Hunter AC, Murray JC. Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol Rev 2001; 53: 283–318.Suche in Google Scholar

Mohandas N, Chasis J. Red blood cell deformability, membrane material properties and shape: regulation by transmembrane, skeletal and cytosolic proteins and lipids. Semin Hematol 1993; 30: 171–192.Suche in Google Scholar

Mohandas N, Gallagher PG. Red cell membrane: past, present, and future. Blood 2008; 112: 3939–3948.10.1182/blood-2008-07-161166Suche in Google Scholar PubMed PubMed Central

Mohanty AK, Dilnawaz F, Mohanta GP, Sahoo SK. Polymer-drug conjugates for targeted drug delivery. In: Devarajan PV, Jain S, editors. Targeted drug delivery: concepts and design. Springer, 2015: 389–407.Suche in Google Scholar

Moser C, Metcalfe IC, Viret J-F. Virosomal adjuvanted antigen delivery systems. Expert Rev Vaccines 2003; 2: 189–196.10.1586/14760584.2.2.189Suche in Google Scholar PubMed

Muro S, Garnacho C, Champion JA, Leferovich J, Gajewski C, Schuchman EH, Mitragotri S, Muzykantov VR. Control of endothelial targeting and intracellular delivery of therapeutic enzymes by modulating the size and shape of ICAM-1-targeted carriers. Mol Ther 2008; 16: 1450–1458.10.1038/mt.2008.127Suche in Google Scholar PubMed PubMed Central

Muzykantov VR. Drug delivery by red blood cells: vascular carriers designed by mother nature. Expert Opin Drug Deliv 2010; 7: 403–427.10.1517/17425241003610633Suche in Google Scholar PubMed PubMed Central

Muzykantov VR. Drug delivery carriers on the fringes: natural red blood cells versus synthetic multilayered capsules. Expert Opin Drug Deliv 2013; 10: 1–4.10.1517/17425247.2013.750292Suche in Google Scholar PubMed

Nel AE, Mädler L, Velegol D, Xia T, Hoek EM, Somasundaran P, Klaessig F, Castranova V, Thompson M. Understanding biophysicochemical interactions at the nano-bio interface. Nat Mater 2009; 8: 543–557.10.1038/nmat2442Suche in Google Scholar PubMed

Nicholson-Weller A, Burge J, Fearon D, Weller P, Austen K. Isolation of a human erythrocyte membrane glycoprotein with decay-accelerating activity for C3 convertases of the complement system. J Immunol 1982; 129: 184–189.10.4049/jimmunol.129.1.184Suche in Google Scholar

Obermeier B, Wurm F, Mangold C, Frey H. Multifunctional poly (ethylene glycol). Angew Chem Int Ed 2011; 50: 7988–7997.10.1002/anie.201100027Suche in Google Scholar PubMed

Ohnishi N, Tanaka S, Tahara K, Takeuchi H. Characterization of insulin-loaded liposome using column-switching HPLC. Int J Pharm 2015; 479: 302–305.10.1016/j.ijpharm.2014.12.056Suche in Google Scholar PubMed

Okada N, Harada R, Fujita T, Okada H. A novel membrane glycoprotein capable of inhibiting membrane attack by homologous complement. Int Immunol 1989; 1: 205–208.10.1093/intimm/1.2.205Suche in Google Scholar PubMed

Oldenborg P-A, Zheleznyak A, Fang Y-F, Lagenaur CF, Gresham HD, Lindberg FP. Role of CD47 as a marker of self on red blood cells. Science 2000; 288: 2051–2054.10.1126/science.288.5473.2051Suche in Google Scholar PubMed

Olson J, Schwartz J, Hahka D, Nguyen N, Bunch T, Jensen G, Adler-Moore J. Toxicity and efficacy differences between liposomal amphotericin B formulations in uninfected and Aspergillus fumigatus infected mice. Med Mycol 2015; 53: 107–118.10.1093/mmy/myu070Suche in Google Scholar PubMed

Owens DE III, Peppas NA. Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Int J Pharmaceut 2006; 307: 93–102.10.1016/j.ijpharm.2005.10.010Suche in Google Scholar PubMed

Parodi A, Quattrocchi N, van de Ven AL, Chiappini C, Evangelopoulos M, Martinez JO, Brown BS, Khaled SZ, Yazdi IK, Enzo MV. Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions. Nat Nanotechnol 2013; 8: 61–68.10.1038/nnano.2012.212Suche in Google Scholar PubMed PubMed Central

Patel SK, Janjic JM. Macrophage targeted theranostics as personalized nanomedicine strategies for inflammatory diseases. Theranostics 2015; 5: 150.10.7150/thno.9476Suche in Google Scholar PubMed PubMed Central

Perry JL, Herlihy KP, Napier ME, DeSimone JM. PRINT: a novel platform toward shape and size specific nanoparticle theranostics. Accounts Chem Res 2011; 44: 990–998.10.1021/ar2000315Suche in Google Scholar PubMed PubMed Central

Pestieau A, Krier F, Lebrun P, Brouwers A, Streel B, Evrard B. Optimization of a PGSS (particles from gas saturated solutions) process for a fenofibrate lipid-based solid dispersion formulation. Int J Pharm 2015; 485: 295–305.10.1016/j.ijpharm.2015.03.027Suche in Google Scholar PubMed

Petros RA, DeSimone JM. Strategies in the design of nanoparticles for therapeutic applications. Nat Rev Drug Discov 2010; 9: 615–627.10.1038/nrd2591Suche in Google Scholar PubMed

Pham D-D, Fattal E, Tsapis N. Pulmonary drug delivery systems for tuberculosis treatment. Int J Pharm 2015; 478: 517–529.10.1016/j.ijpharm.2014.12.009Suche in Google Scholar PubMed

Piao J-G, Wang L, Gao F, You Y-Z, Xiong Y, Yang L. Erythrocyte-membrane is an alternative coating to polyethylene glycol for prolonging the circulation lifetime of gold nanocages for photothermal therapy. ACS Nano. 2014; 8: 10414–10425.10.1021/nn503779dSuche in Google Scholar PubMed

Polyak B, Friedman G. Magnetic targeting for site-specific drug delivery: applications and clinical potential. Expert Opin Drug Deliv 2009; 6: 53–70.10.1517/17425240802662795Suche in Google Scholar PubMed

Poon C, He C, Liu D, Lu K, Lin W. Self-assembled nanoscale coordination polymers carrying oxaliplatin and gemcitabine for synergistic combination therapy of pancreatic cancer. J Control Release 2015; 201: 90–99.10.1016/j.jconrel.2015.01.026Suche in Google Scholar PubMed PubMed Central

Ramalingam N, Natarajan T, Rajiv S. Preparation and characterization of electrospun curcumin loaded poly (2-hydroxyethyl methacrylate) nanofiber – a biomaterial for multidrug resistant organisms. J Biomed Mater Res A 2015; 103: 16–24.10.1002/jbm.a.35138Suche in Google Scholar PubMed

Refuerzo JS, Alexander JF, Leonard F, Leon M, Longo M, Godin B. Liposomes: a nanoscale drug carrying system to prevent indomethacin passage to the fetus in a pregnant mouse model. Am J Obstet Gynecol 2015; 212: 508.e1–7.10.1016/j.ajog.2015.02.006Suche in Google Scholar PubMed

Rincón R, Cristóbal I, Zazo S, Arpí O, Menéndez S, Manso R, Lluch A, Eroles P, Rovira A, Albanell J, García-Foncillas J, Madoz-Gúrpide J, Rojo F. PP2A inhibition determines poor outcome and doxorubicin resistance in early breast cancer and its activation shows promising therapeutic effects. Oncotarget 2015; 6: 4299–4314.10.18632/oncotarget.3012Suche in Google Scholar PubMed PubMed Central

Rösler A, Vandermeulen GW, Klok H-A. Advanced drug delivery devices via self-assembly of amphiphilic block copolymers. Adv Drug Deliv Rev 2012; 64: 270–279.10.1016/j.addr.2012.09.026Suche in Google Scholar

Ruffini PA, Vaja V, Allegretti M. Improving cancer therapy by targeting cancer stem cells: directions, challenges, and clinical results. World J Pharmacol 2015; 4: 58–74.10.5497/wjp.v4.i1.58Suche in Google Scholar

Sawdon A, Peng C-A. Engineering antiphagocytic biomimetic drug carriers. Therapeut Deliv 2013; 4: 825–839.10.4155/tde.13.54Suche in Google Scholar PubMed PubMed Central

Scarano W, de Souza P, Stenzel MH. Dual-drug delivery of curcumin and platinum drugs in polymeric micelles enhances the synergistic effects: a double act for the treatment of multidrug-resistant cancer. Biomater Sci 2015; 3: 163–174.10.1039/C4BM00272ESuche in Google Scholar

Scherließ R. Nasal administration of vaccines. Subunit vaccine delivery. New York: Springer, 2015: 287–306.10.1007/978-1-4939-1417-3_15Suche in Google Scholar

Schönermark S, Rauterberg E, Shin M, Löke S, Roelcke D, Hänsch G. Homologous species restriction in lysis of human erythrocytes: a membrane-derived protein with C8-binding capacity functions as an inhibitor. J Immunol 1986; 136: 1772–1776.10.4049/jimmunol.136.5.1772Suche in Google Scholar

Shah S. Novel drug delivery carrier: resealed erythrocytes. Int J Pharm Biosci 2011; 2: 395–406.Suche in Google Scholar

Sharma AK, Sharma R, Jhorar R, Kumar R. Nanomedicine in therapeutic intervention of tuberculosis meningitis. Curr Nanosci 2015; 11: 15–22.10.2174/1573413710666141016000110Suche in Google Scholar

Shi J, Kundrat L, Pishesha N, Bilate A, Theile C, Maruyama T, Dougan SK, Ploegh HL, Lodish HF. Engineered red blood cells as carriers for systemic delivery of a wide array of functional probes. Proc Natl Acad Sci 2014; 111: 10131–10136.10.1073/pnas.1409861111Suche in Google Scholar

Shim WS, Kim J-H, Kim K, Kim Y-S, Park R-W, Kim I-S, Kwon IC, Lee DS. pH-and temperature-sensitive, injectable, biodegradable block copolymer hydrogels as carriers for paclitaxel. Int J Pharm 2007; 331: 11–18.10.1016/j.ijpharm.2006.09.027Suche in Google Scholar

Simone EA, Dziubla TD, Muzykantov VR. Polymeric carriers: role of geometry in drug delivery. 2008; 5: 1283–1300.10.1517/17425240802567846Suche in Google Scholar

Soppimath KS, Aminabhavi TM, Kulkarni AR, Rudzinski WE. Biodegradable polymeric nanoparticles as drug delivery devices. J Control Release 2001; 70: 1–20.10.1016/S0168-3659(00)00339-4Suche in Google Scholar

Sprandel U. Towards cellular drug targeting and controlled release of drugs by magnetic fields. Adv Biosci 1987; 67: 243–250.Suche in Google Scholar

Sudhakar B, Krishna MC, Murthy KVR. Factorial design studies of antiretroviral drug-loaded stealth liposomal injectable: PEGylation, lyophilization and pharmacokinetic studies. Appl Nanosci 2015; 1–18.10.1007/s13204-015-0408-8Suche in Google Scholar

Sugita Y, Nakano Y, Tomita M. Isolation from human erythrocytes of a new membrane protein which inhibits the formation of complement transmembrane channels. J Biochem 1988; 104: 633–637.10.1093/oxfordjournals.jbchem.a122524Suche in Google Scholar

Summers M. Recent advances in drug delivery. Pharm J 1983; 230: 643–645.Suche in Google Scholar

Sun X, Wang C, Gao M, Hu A, Liu Z. Remotely controlled red blood cell carriers for cancer targeting and near-infrared light-triggered drug release in combined photothermal-chemotherapy. Adv Funct Mater 2015; 25: 2386–2394.10.1002/adfm.201500061Suche in Google Scholar

Svenson S, Chauhan AS. Dendrimers for enhanced drug solubilization. Nanomedicine (Lond). 2008; 3: 679–702.10.2217/17435889.3.5.679Suche in Google Scholar

Tajerzadeh H, Hamidi M. Evaluation of hypotonic preswelling method for encapsulation of enalaprilat in intact human erythrocytes. Drug Devel Indus Pharm 2000; 26: 1247–1257.10.1081/DDC-100102306Suche in Google Scholar

Tanford C. The hydrophobic effect: formation of micelles and biological membranes, 2nd ed., New York: Wiley, 1980.Suche in Google Scholar

Tardieu A, Luzzati V, Reman F. Structure and polymorphism of the hydrocarbon chains of lipids: a study of lecithin-water phases. J Mol Biol 1973; 75: 711–733.10.1016/0022-2836(73)90303-3Suche in Google Scholar

Tian G, Zheng X, Zhang X, Yin W, Yu J, Wang D, Zhang Z, Yang X, Gu Z, Zhao Y. TPGS-stabilized NaYbF 4: Er upconversion nanoparticles for dual-modal fluorescent/CT imaging and anticancer drug delivery to overcome multi-drug resistance. Biomaterials 2015; 40: 107–116.10.1016/j.biomaterials.2014.11.022Suche in Google Scholar

Torchilin VP. Recent advances with liposomes as pharmaceutical carriers. Nat Rev Drug Discov 2005; 4: 145–160.10.1038/nrd1632Suche in Google Scholar

Uhrich KE, Cannizzaro SM, Langer RS, Shakesheff KM. Polymeric systems for controlled drug release. Chem Rev 1999; 99: 3181–3198.10.1021/cr940351uSuche in Google Scholar

Vahidkhah K, Bagchi P. Microparticle shape effects on margination, near-wall dynamics and adhesion in a three-dimensional simulation of red blood cell suspension. Soft Matter. 2015; 11: 2097–2109.10.1039/C4SM02686ASuche in Google Scholar

Valbonesi M, Bruni R, Florio G, Zanella A, Bunkens H. Cellular contamination of plasma collected with various apheresis systems. Transfus Apher Sci 2001; 24: 91–94.10.1016/S0955-3886(00)00128-4Suche in Google Scholar

Varypataki EM, van der Maaden K, Bouwstra J, Ossendorp F, Jiskoot W. Cationic liposomes loaded with a synthetic long Peptide and poly (I:C): a defined adjuvanted vaccine for induction of antigen-specific T cell cytotoxicity. AAPS J 2015; 17: 216–226.10.1208/s12248-014-9686-4Suche in Google Scholar PubMed PubMed Central

Vercauteren D, Vandenbroucke RE, Jones AT, Rejman J, Demeester J, De Smedt SC, Sanders NN, Braeckmans K. The use of inhibitors to study endocytic pathways of gene carriers: optimization and pitfalls. Mol Ther 2009; 18: 561–569.10.1038/mt.2009.281Suche in Google Scholar PubMed PubMed Central

Verma A, Stellacci F. Effect of surface properties on nanoparticle-cell interactions. Small 2010; 6: 12–21.10.1002/smll.200901158Suche in Google Scholar PubMed

Vogelbaum MA, Aghi MK. Convection-enhanced delivery for the treatment of glioblastoma. Neuro-oncology 2015; 17(Suppl 2): ii3–ii8.10.1093/neuonc/nou354Suche in Google Scholar PubMed PubMed Central

Wan J, Forsyth AM, Stone HA. Red blood cell dynamics: from cell deformation to ATP release. Integrat Biol 2011; 3: 972–981.10.1039/c1ib00044fSuche in Google Scholar PubMed

Wang C-J, Chen T-C, Lin J-H, Huang P-R, Tsai H-J, Chen C-S. One-step preparation of hydrophilic carbon nanofiber containing magnetic Ni nanoparticles materials and their application in drug delivery. J Colloid Interface Sci 2015a; 440: 179–188.10.1016/j.jcis.2014.10.073Suche in Google Scholar PubMed

Wang H-Q, Jin J-J, Wang J. Matrine induces mitochondrial apoptosis in cisplatin-resistant non-small cell lung cancer cells via suppression of β-catenin/survivin signaling. Oncol Rep 2015b; 33: 2561–2566.10.3892/or.2015.3844Suche in Google Scholar PubMed

Wang L, Zhang Y, Hu X, Chang X. A randomized comparison of onset of anesthesia between spinal Bupivacaine 5 mg with immediate epidural 2% lidocaine 5 mL and bupivacaine 10 mg for cesarean delivery. Obstet Anesth Digest 2015c; 35: 51–52.10.1097/01.aoa.0000460426.11682.feSuche in Google Scholar

Wang H, VerHalen J, Madariaga ML, Xiang S, Wang S, Lan P, Oldenborg P-A, Sykes M, Yang Y-G. Attenuation of phagocytosis of xenogeneic cells by manipulating CD47. Blood 2007; 109: 836–842.10.1182/blood-2006-04-019794Suche in Google Scholar PubMed PubMed Central

Xiao K, Li Y, Luo J, Lee JS, Xiao W, Gonik AM, Agarwal RG, Lam KS. The effect of surface charge on in vivo biodistribution of PEG-oligocholic acid based micellar nanoparticles. Biomaterials 2011; 32: 3435–3446.10.1016/j.biomaterials.2011.01.021Suche in Google Scholar PubMed PubMed Central

Xu J, Zhao Q, Jin Y, Qiu L. High loading of hydrophilic/hydrophobic doxorubicin into polyphosphazene polymersome for breast cancer therapy. Nanomed Nanotechnol Biol Med 2014; 10: 349–358.10.1016/j.nano.2013.08.004Suche in Google Scholar PubMed

Xu F, Weng B, Gilkerson R, Materon LA and Lozano K. Development of tannic acid/chitosan/pullulan composite nanofibers from aqueous solution for potential applications as wound dressing. Carbohydr Polym 2015a; 115: 16–24.10.1016/j.carbpol.2014.08.081Suche in Google Scholar PubMed

Xu X, Ho W, Zhang X, Bertrand N, Farokhzad O. Cancer nanomedicine: from targeted delivery to combination therapy. Trends Molecul Med 2015b; 21: 223–232.10.1016/j.molmed.2015.01.001Suche in Google Scholar PubMed PubMed Central

Xu ZP, Zeng QH, Lu GQ and Yu AB. Inorganic nanoparticles as carriers for efficient cellular delivery. Chem Eng Sci 2006; 61: 1027–1040.10.1016/j.ces.2005.06.019Suche in Google Scholar

Yadav SM, Gattacceca F, Panicucci R, Amiji MM. Comparative biodistribution and pharmacokinetic analysis of cyclosporine-A in the brain upon intranasal and intravenous administration in an oil-in-water nanoemulsion formulation. Mol Pharm 2015; 12: 1523–1533.10.1021/mp5008376Suche in Google Scholar PubMed

Yang L, Alexandridis P. Physicochemical aspects of drug delivery and release from polymer-based colloids. Curr Opin Colloid Interface Sci 2000; 5: 132–143.10.1016/S1359-0294(00)00046-7Suche in Google Scholar

Yazdanbakhsh K, Lomas-Francis C, Reid ME. Blood groups and diseases associated with inherited abnormalities of the red blood cell membrane. Transfus Med Rev 2000; 14: 364–374.10.1053/tmrv.2000.16232Suche in Google Scholar

Yong-Hee K, Bae YH, Kim SW. pH/temperature-sensitive polymers for macromolecular drug loading and release. J Control Release 1994; 28: 143–152.10.1016/0168-3659(94)90161-9Suche in Google Scholar

Yoo J-W, Doshi N, Mitragotri S. Adaptive micro and nanoparticles: temporal control over carrier properties to facilitate drug delivery. Adv Drug Deliv Rev 2011a; 63: 1247–1256.10.1016/j.addr.2011.05.004Suche in Google Scholar PubMed

Yoo J-W, Irvine DJ, Discher DE, Mitragotri S. Bio-inspired, bioengineered and biomimetic drug delivery carriers. Nat Rev Drug Discov 2011b; 10: 521–535.10.1038/nrd3499Suche in Google Scholar PubMed

Zalman LS, Wood LM, Müller-Eberhard HJ. Isolation of a human erythrocyte membrane protein capable of inhibiting expression of homologous complement transmembrane channels. Proc Natl Acad Sci 1986; 83: 6975–6979.10.1073/pnas.83.18.6975Suche in Google Scholar PubMed PubMed Central

Zarrin A, Foroozesh M, Hamidi M. Carrier erythrocytes: recent advances, present status, current trends and future horizons. Expert Opin Drug Deliv 2014; 11: 433–447.10.1517/17425247.2014.880422Suche in Google Scholar PubMed

Zhang L, Hu C-MJ, Fang RH, Copp J. Membrane encapsulated nanoparticles and method of use, Google Patents, Publication number US20130337066 A1, 2013.Suche in Google Scholar

Zhang H, Huang X, Sun Y, Xing J, Yamamoto A, Gao Y. Absorption-improving effects of chitosan oligomers based on their mucoadhesive properties: a comparative study on the oral and pulmonary delivery of calcitonin. Drug Deliv 2015a; 1–9.10.3109/10717544.2014.1002946Suche in Google Scholar PubMed

Zhang W, Hu M, Shi Y, Gong T, Dezzutti CS, Moncla B, Sarafianos SG, Parniak MA, Rohan LC. Vaginal microbicide film combinations of two reverse transcriptase inhibitors, EFdA and CSIC, for the prevention of HIV-1 sexual transmission. Pharm Res 2015b; 1–13.10.1007/s11095-015-1678-2Suche in Google Scholar PubMed PubMed Central

Zhang Y, Zhang K, Guo T, Li Y, Zhu C, Feng N. Transdermal baicalin delivery using diethylene glycol monoethyl ether-mediated cubic phase gel. Int J Pharm 2015c; 479: 219–226.10.1016/j.ijpharm.2014.12.055Suche in Google Scholar PubMed

Zhou Z, Ma X, Jin E, Tang J, Sui M, Shen Y, Van Kirk EA, Murdoch WJ, Radosz M. Linear-dendritic drug conjugates forming long-circulating nanorods for cancer-drug delivery. Biomaterials 2013; 34: 5722–5735.10.1016/j.biomaterials.2013.04.012Suche in Google Scholar PubMed

Zuwala K, Smith AA, Postma A, C. Guerrero-Sanchez, Ruiz-Sanchis P, Melchjorsen J, Tolstrup M, Zelikin AN. Polymers fight HIV: potent (pro) drugs identified through parallel automated synthesis. Adv Healthc Mater 2015; 4: 46–50.10.1002/adhm.201400148Suche in Google Scholar PubMed

Received: 2015-2-24
Accepted: 2015-4-2
Published Online: 2015-8-26
Published in Print: 2015-10-1

©2015 by De Gruyter

Heruntergeladen am 6.9.2025 von https://www.degruyterbrill.com/document/doi/10.1515/revce-2015-0010/html
Button zum nach oben scrollen