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Fetal thymus size in pregnant women with diabetic diseases

  • Ria Dörnemann EMAIL logo , Raphael Koch , Ute Möllmann , Maria Karina Falkenberg , Mareike Möllers , Walter Klockenbusch und Ralf Schmitz
Veröffentlicht/Copyright: 14. Februar 2017

Abstract

Aim:

The aim of our study was to assess fetal thymus size in diabetic pregnancies compared with normal pregnancies.

Methods:

Sonographic fetal thymus size was retrospectively assessed in 161 pregnancies with maternal diabetes and in 161 uncomplicated pregnancies matched by gestational age. The anteroposterior thymic and the intrathoracic mediastinal diameter were measured and the quotient was calculated [thymic-thoracic ratio (TT-ratio)]. In addition, we defined the quotient of the anteroposterior thymic diameter and the head circumference as thymus-head ratio (TH-ratio). The maternal diabetes cases were subdivided into three groups: (1) diet-controlled gestational diabetes, (2) insulin-dependent gestational diabetes and (3) preexisting maternal diabetes.

Results:

TT-ratio and TH-ratio were smaller in pregnancies with maternal diabetes (P<0.001 and P<0.001, respectively). In all three maternal diabetes subgroups, the TT-ratio and the TH-ratio were lower compared with the control group (P<0.001 for each group).

Conclusions:

Reduced fetal thymus size seems to be associated with diabetic pregnancy. We introduce fetal thymus size as a new potential prognostic parameter for maternal diabetes.

  1. Author’s statement

  2. Conflict of interest: Authors state no conflict of interest.

  3. Materials and methods: Informed consent: Informed consent has been obtained from all individuals included in this study.

  4. Ethical approval: The research related to human subject use has complied with all the relevant national regulations, and institutional policies, and is in accordance with the tenets of the Helsinki Declaration, and has been approved by the authors’ institutional review board or equivalent committee.

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Received: 2016-7-21
Accepted: 2017-1-10
Published Online: 2017-2-14
Published in Print: 2017-7-26

©2017 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Review articles
  3. Mycoplasma/Ureaplasma infection in pregnancy: to screen or not to screen
  4. Increased rates of cesarean sections and large families: a potentially dangerous combination
  5. Original articles - Obstetrics
  6. Clinical chorioamnionitis at term VII: the amniotic fluid cellular immune response
  7. Clinical chorioamnionitis at term VIII: a rapid MMP-8 test for the identification of intra-amniotic inflammation
  8. The importance of clinically and ethically fine-tuning decision-making about cesarean delivery
  9. Use of translabial three-dimensional power Doppler ultrasound for cervical assessment before labor induction
  10. Perinatal death associated with umbilical cord prolapse
  11. YKL-40 expression in abnormal invasive placenta cases
  12. B-type natriuretic peptide and echocardiography reflect volume changes during pregnancy
  13. Original articles - Fetus
  14. Evidence-based, ethically justified counseling for fetal bilateral renal agenesis
  15. Fetal thymus size in pregnant women with diabetic diseases
  16. Birth weight discordance and adverse perinatal outcomes
  17. Original articles - Newborn
  18. Carboxyhemoglobin – the forgotten parameter of neonatal hyperbilirubinemia
  19. Growth attainment in German children born preterm, and cardiovascular risk factors in adolescence. Analysis of the population representative KiGGS data
  20. Fresh frozen plasma transfusion – a risk factor for pulmonary hemorrhage in extremely low birth weight infants?
  21. Letter to the Editor
  22. Risk factors for uterine rupture with a special interest in uterine fundal pressure: methodological issues
  23. Congress Calendar
  24. Congress Calendar
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