Abstract
Objective:
YKL-40 is a secreted glycoprotein and has been implicated in the proliferation and differentiation of malignant cells, extracellular tissue remodelling, neovascularisation, inhibition of cancer cell apoptosis and stimulation of tumour-associated fibroblasts. The purpose of this study was to evaluate YKL-40 tissue expression in extravillous trophoblast invasion and its possible implication in placenta creta.
Methods:
A total of 35 placenta creta cases and six control cases were included in the study, of which eight cases were placenta accreta, 12 were increta and 15 were percreta. Histological YKL-40 staining was scored in tissue as weak (1), medium (2) and strong (3).
Results:
YKL-40 immunoreactivity intensity in the percreta group was significantly higher compared to the increta and accreta groups (2.47±0.74, 1.33±0.49 and 1.37±0.52, respectively; P=0.000). YKL-40 immunoreactivity intensity was positively correlated with creta (r=0.6; P=0.000), depth of invasion (r=0.49; P=0.003) and depth of invasion to full thickness ratio (r=0.58; P=0.000).
Conclusion:
This study demonstrated that YKL-40 is strongly expressed in placenta percreta and is correlated with extravillous trophoblast invasion. These findings may be informative for understanding the pathophysiology of placenta creta.
Acknowledgments
The Department of Scientific Research Project’s in Mustafa Kemal University supported this work.
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©2017 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Review articles
- Mycoplasma/Ureaplasma infection in pregnancy: to screen or not to screen
- Increased rates of cesarean sections and large families: a potentially dangerous combination
- Original articles - Obstetrics
- Clinical chorioamnionitis at term VII: the amniotic fluid cellular immune response
- Clinical chorioamnionitis at term VIII: a rapid MMP-8 test for the identification of intra-amniotic inflammation
- The importance of clinically and ethically fine-tuning decision-making about cesarean delivery
- Use of translabial three-dimensional power Doppler ultrasound for cervical assessment before labor induction
- Perinatal death associated with umbilical cord prolapse
- YKL-40 expression in abnormal invasive placenta cases
- B-type natriuretic peptide and echocardiography reflect volume changes during pregnancy
- Original articles - Fetus
- Evidence-based, ethically justified counseling for fetal bilateral renal agenesis
- Fetal thymus size in pregnant women with diabetic diseases
- Birth weight discordance and adverse perinatal outcomes
- Original articles - Newborn
- Carboxyhemoglobin – the forgotten parameter of neonatal hyperbilirubinemia
- Growth attainment in German children born preterm, and cardiovascular risk factors in adolescence. Analysis of the population representative KiGGS data
- Fresh frozen plasma transfusion – a risk factor for pulmonary hemorrhage in extremely low birth weight infants?
- Letter to the Editor
- Risk factors for uterine rupture with a special interest in uterine fundal pressure: methodological issues
- Congress Calendar
- Congress Calendar
Articles in the same Issue
- Frontmatter
- Review articles
- Mycoplasma/Ureaplasma infection in pregnancy: to screen or not to screen
- Increased rates of cesarean sections and large families: a potentially dangerous combination
- Original articles - Obstetrics
- Clinical chorioamnionitis at term VII: the amniotic fluid cellular immune response
- Clinical chorioamnionitis at term VIII: a rapid MMP-8 test for the identification of intra-amniotic inflammation
- The importance of clinically and ethically fine-tuning decision-making about cesarean delivery
- Use of translabial three-dimensional power Doppler ultrasound for cervical assessment before labor induction
- Perinatal death associated with umbilical cord prolapse
- YKL-40 expression in abnormal invasive placenta cases
- B-type natriuretic peptide and echocardiography reflect volume changes during pregnancy
- Original articles - Fetus
- Evidence-based, ethically justified counseling for fetal bilateral renal agenesis
- Fetal thymus size in pregnant women with diabetic diseases
- Birth weight discordance and adverse perinatal outcomes
- Original articles - Newborn
- Carboxyhemoglobin – the forgotten parameter of neonatal hyperbilirubinemia
- Growth attainment in German children born preterm, and cardiovascular risk factors in adolescence. Analysis of the population representative KiGGS data
- Fresh frozen plasma transfusion – a risk factor for pulmonary hemorrhage in extremely low birth weight infants?
- Letter to the Editor
- Risk factors for uterine rupture with a special interest in uterine fundal pressure: methodological issues
- Congress Calendar
- Congress Calendar