The effect of fish oil supplementation on maternal and neonatal outcomes: a triple-blind, randomized controlled trial

Alireza Ostadrahimi; Sakineh Mohammad-Alizadeh; Mojgan Mirghafourvand; Shadi Farshbaf-Khalili; Nayyer Jafarilar-Agdam; Azizeh Farshbaf-Khalili

doi:10.1515/jpm-2016-0037

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The effect of fish oil supplementation on maternal and neonatal outcomes: a triple-blind, randomized controlled trial

Alireza Ostadrahimi , Sakineh Mohammad-Alizadeh , Mojgan Mirghafourvand , Shadi Farshbaf-Khalili , Nayyer Jafarilar-Agdam und Azizeh Farshbaf-Khalili

Veröffentlicht/Copyright: 31. Januar 2017

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Aus der Zeitschrift Journal of Perinatal Medicine Band 45 Heft 9

Abstract

Objective:

To evaluate the effect of fish oil supplementation on pregnancy outcomes in mother and newborn.

Methods:

This randomized, triple-blind, placebo-controlled trial was conducted on 150 pregnant women aged 18–35 years from Feburary 2014 to April 2015 in Tabriz, Iran. Participants were assigned to receive either 1000 mg fish oil supplements containing 180 mg eicosapentaenoic acid (EPA) and 120 mg docosahexanoic acid or placebo from week 20 of gestation to birth. The primary outcome measure was birth weight. Gestational duration, preterm labor low birth weight (LBW), length, head circumference, and maternal serum docosahexaenoic acid (DHA) and EPA level at 35–37 weeks were also examined. The statistical analysis was on an intention-to-treat basis.

Results:

Demographic characteristics were similar in both groups (P>0.05). The mean (SD) birth weight values in the fish oil and placebo groups were 3256 (362) g and 3172 (447) g, respectively (adjusted mean difference (MD)=84.1 g, 95% confidence interval [CI]=−24.8 to 193.2). Five (7.6%) neonates in the placebo versus no case in the fish oil group were born with LBW (P=0.02). The rate of preterm labor was lower in the fish oil group (adjusted OR=0.74, 95% CI=0.16–3.42). However, there were no statistically significant differences in the maternal outcomes (P>0.05) with the exception of the proportion of maternal serum DHA fatty acid at 35–37 weeks (P<0.001).

Conclusion:

Although low dose fish oil supplementation increased birth weight, its effect was not statistically significant. The frequency of LBW was significantly reduced in the intervention group, but the observed reduction needs to be confirmed in future larger investigations using different doses of omega-3.

Keywords: fish oil supplemention; mothers; neonates; nutritional status; omega-3; pregnancy

Acknowledgments

This study resulted from a PhD thesis that has been approved by the Tabriz Health Services Management Research Center (grant no. 5/77/5241). The authors would like to appreciate the research deputy of the Chromatography Laboratory, Faculty of Medicine, Tabriz University of Medical Sciences; the Zahravi Pharmacy Company; the Health Department of Tabriz; the authorities and staff of health centers; and all women who patiently assisted us in collecting data. They also thank Dr Masoud Darabi from the Faculty of Medicine, Tabriz University of Medical Sciences, Iran, for analysis of fatty acids.

Author’s statement

Conflict of interest: Authors state no conflict of interest.
Material and methods: Informed consent has been obtained from all individuals included in this study.
Ethical approval: The research related to human use has been complied with all the relevant national regulation, and institutional policies, is in accordance the tenets of the Helsinki Declaration, and has been approved by the authors’ institutional review board or equivalent committee.
Source of funding: This study was supported by Tabriz University of Medical Sciences.

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Received: 2016-1-30

Accepted: 2016-12-9

Published Online: 2017-1-31

Published in Print: 2017-12-20

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https://doi.org/10.1515/jpm-2016-0037

Schlagwörter für diesen Artikel

fish oil supplemention; mothers; neonates; nutritional status; omega-3; pregnancy