Evaluation of the role of FTO (rs9939609) and MC4R (rs17782313) gene polymorphisms in type 1 diabetes and their relation to obesity
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Youssef M. Mosaad
Abstract
Objectives
This study aims to explore the effects of fat mass obesity-associated (FTO) (rs9939609) and melanocortin 4 receptor (MC4R) (rs17782313) gene polymorphisms in children with type 1 diabetes (T1D) and their relation to obesity.
Methods
Fat mass obesity-associated (FTO) (rs9939609) and melanocortin 4 receptor (MC4R) (rs17782313) gene polymorphisms were evaluated in 164 patients and 100 controls, and genotypes, alleles, and haplotype frequencies were compared between cases and controls.
Results
A significant association with T1D development was found with the TC, CC, and TC+CC genotypes and the C allele of MC4R rs17782313. In addition, TA, AA, and TA+AA genotypes and the A allele of FTO rs9939609 may also be risky for T1D development. While the TC and TC+CC genotypes of MC4R rs17782313 may be protective against obesity development, the AA genotype and A allele of FTO rs9939609 may also be protective against obesity development. Regarding obese subjects, comparing diabetics vs. non-diabetic studied subjects, FTO rs9939609, TA, AA, and TA+AA genotypes and the A allele had significantly higher frequencies in T1D with a higher risk of developing T1D. However, conducting multivariable analysis using significant covariates in univariable analysis revealed that only earlier age of T1D onset, lower C-peptide, and the MC4R dominant model were considered independent predictors of obesity within T1D.
Conclusions
The role of both genes’ polymorphisms on the pathogenesis and the outcome of T1D and obesity can help in understanding the pathogenesis of both diseases and their associations with each other’s and may be used as novel therapeutic targets for both diseases.
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Ethical approval: This study was approved by the Institutional Research Council of the Mansoura Faculty of Medicine under proposal code MD.19.01.123.R1.
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Informed consent: Informed consent was obtained from all individuals included in this study.
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Author contributions: YMM conceived and designed the study, interpreted the data, contributed data or analysis tools, supervised the study and approved the final version of the manuscript. MM selection of the patients, performed experiments, collected the data, and statistical analysis. MA wrote the paper, contact journals, language editing, supervised the study, and approved the final version of the manuscript. FAEAEC AND AAE supervised the study, and approved the final version of the study. The authors read and approved the final manuscript.
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Competing interests: Authors state no conflict of interest.
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Research funding: None declared.
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Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
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© 2023 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
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- Lack of association between month of birth and risk of developing type 1 diabetes in Brazil: a 40-year analysis
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Artikel in diesem Heft
- Frontmatter
- Review
- Myoinositol or D-chiro-inositol for PCOS symptoms in adolescents: a narrative review
- Mini Review
- Effects of the COVID-19 pandemic on the incidence of central precocious puberty; a narrative review
- Original Articles
- Evaluation of the role of FTO (rs9939609) and MC4R (rs17782313) gene polymorphisms in type 1 diabetes and their relation to obesity
- Lack of association between month of birth and risk of developing type 1 diabetes in Brazil: a 40-year analysis
- Review on the screening of urine glucose for early diagnosis of type 2 diabetes mellitus in school children and adolescents with obesity in Hong Kong
- Effect of daily zinc supplementation for 12 weeks on serum thyroid auto-antibody levels in children and adolescents with autoimmune thyroiditis – a randomized controlled trial
- Correlation between serum vitamin D level and uterine volume in girls with idiopathic central precocious puberty
- Diagnostic model based on multiple factors for girls with central precocious puberty
- Validity and reliability of parent assessments of pubertal maturation among adolescent girls in Isfahan, Iran
- Newborn screening for primary carnitine deficiency using a second-tier genetic test
- Case Reports
- From neglect to peril: diabetic ketoacidosis unleashing colonic necrosis and perforation in an adolescent girl with type 1 diabetes mellitus
- Unusual onset of Graves’ disease associated with thymic hyperplasia in a 5-year-old girl with congenital bilateral clinical anophthalmia: diagnostic and therapeutic challenges
- Thyroid hormone resistance and large goiter mimicking infiltrative carcinoma in a pediatric patient
- Hereditary hypomagnesemia with secondary hypocalcemia caused by a novel mutation in TRPM6 gene
- Letter to the Editor
- Congenital hyperinsulinism patient with ABCC8 and KCNJ11 double heterozygous variants: a case report with 6 years follow-up
