Startseite The association between prenatal exposure to organochlorine compounds and neonatal thyroid hormone levels: a systematic review
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The association between prenatal exposure to organochlorine compounds and neonatal thyroid hormone levels: a systematic review

  • Mahshid Gheidarloo , Roya Kelishadi , Silva Hovsepian , Mojtaba Keikha und Mahin Hashemipour EMAIL logo
Veröffentlicht/Copyright: 19. Dezember 2019
Journal of Pediatric Endocrinology and Metabolism
Aus der Zeitschrift Journal of Pediatric Endocrinology and Metabolism Band 33 Heft 1

Abstract

In this systematic review, the association between prenatal exposure to organochlorine pesticides (OCPs) and neonatal thyroid hormone levels was studied. A systematic search of scientific literature was performed from the PubMed, SCOPUS and ISI web of science electronic bibliographic databases. The search strategy for the review was [(organochlorine OR “organochlorine pesticides” OR “organochlorine pollutants” OR “organochlorine pollutant”) AND (“thyroid hormone” OR triiodothyronine OR Thyroxine OR “fetal thyroid function” OR “thyroid function” OR “Thyroid Stimulating Hormone” AND “prenatal” AND “maternal exposure”)] in English sources. In this review, 305 papers (PubMed: 30; Scopus: 29; ISI: 246) were identified through an electronic database search. Twenty-seven articles were assessed for eligibility, from which 16 qualified articles were selected for the final evaluation. The most common OCP metabolites which were evaluated in order were hexachlorobenzene (HCB) (13 studies), pp-dichlorodiphenyldichloroethylene (pp-DDE) (13 studies), hexachlorocyclohexane (HCH) (10 studies) and dichlorodiphenyltrichlorethane (DDT) (eight studies). A review of the documents related to the association of prenatal exposure of OCPs with fetal or neonatal thyroid function tests provides us with heterogeneous data in this field. Factors such as differences in the studied populations and their area, ethnic and genetic background, time and rate of exposure, possible interaction of other thyroid-disrupting environmental factors and dietary intake of micronutrients such as iodine and/or selenium are considered the main limitations for making an accurate conclusion. For some OCPs including DDT, DDE, HCH and HCB, there are supporting evidences, and it is suggested that their exposure could potentially alter the fetal thyroid function and consequently impair the neurodevelopment process of the infants.

Keywords: neonate; organochlorine; prenatal exposure; thyroid hormones
Corresponding author: Prof. Mahin Hashemipour, Isfahan Endocrine and Metabolism Research Center, Pediatrics Department, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran

  1. Author contribution: All authors contributed in the conception, design and all stages of the review study. All authors contributed in the preparing the draft of the manuscript and all of them read and confirmed the final version of the manuscript.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2019-07-20
Accepted: 2019-10-18
Published Online: 2019-12-19
Published in Print: 2020-01-28

©2020 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. Inborn errors of metabolism
  4. Reviews
  5. Nutrition and medical support during pregnancy and lactation in women with inborn errors of intermediary metabolism disorders (IEMDs)
  6. The association between prenatal exposure to organochlorine compounds and neonatal thyroid hormone levels: a systematic review
  7. Original Articles
  8. Investigating the incidence rate and geographical distribution of congenital hypothyroidism among neonates in Isfahan province using geographic information system (GIS) between 2002 and 2015
  9. Analysis of five cases of hypermethioninemia diagnosed by neonatal screening
  10. What is the evidence for beneficial effects of growth hormone treatment beyond height in short children born small for gestational age? A review of published literature
  11. Machine learning-based prediction of response to growth hormone treatment in Turner syndrome: the LG Growth Study
  12. Pathogenic/likely pathogenic variants in the SHOX, GHR and IGFALS genes among Indian children with idiopathic short stature
  13. Celiac disease in Saudi children with isolated short stature: is it rare or are we not screening rigorously enough?
  14. The beneficial effect of psychological support on mothers with PKU children who suffer from social discrimination and damage of quality of life
  15. Long-term effects of GnRH agonist treatment on body mass index in girls with idiopathic central precocious puberty
  16. Sudden sex hormone withdrawal and the effects on body composition in late pubertal adolescents with gender dysphoria
  17. The alteration of IGF-1 levels and relationship between IGF-1 levels and growth velocity during GnRH analogue therapy
  18. BMI relationship to the onset of puberty: assessment of growth parameters and sexual maturity changes in Egyptian children and adolescents of both sexes
  19. The effects of a 12-week jump rope exercise program on body composition, insulin sensitivity, and academic self-efficacy in obese adolescent girls
  20. Onset of pituitary hormone deficiencies in optic nerve hypoplasia: a temporal trend analysis of 32 children at Mayo Clinic
  21. Dietary practices in methylmalonic acidaemia: a European survey
  22. Case Reports
  23. Clinical findings in five Turkish patients with citrin deficiency and identification of a novel mutation on SLC25A13
  24. A rare case of primary coenzyme Q10 deficiency due to COQ9 mutation
  25. Sinusitis, an under-reported adverse effect in children treated with radioactive iodine therapy and review of the current literature
  26. Acknowledgment
https://doi.org/10.1515/jpem-2019-0336
Schlagwörter für diesen Artikel
neonate; organochlorine; prenatal exposure; thyroid hormones

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. Inborn errors of metabolism
  4. Reviews
  5. Nutrition and medical support during pregnancy and lactation in women with inborn errors of intermediary metabolism disorders (IEMDs)
  6. The association between prenatal exposure to organochlorine compounds and neonatal thyroid hormone levels: a systematic review
  7. Original Articles
  8. Investigating the incidence rate and geographical distribution of congenital hypothyroidism among neonates in Isfahan province using geographic information system (GIS) between 2002 and 2015
  9. Analysis of five cases of hypermethioninemia diagnosed by neonatal screening
  10. What is the evidence for beneficial effects of growth hormone treatment beyond height in short children born small for gestational age? A review of published literature
  11. Machine learning-based prediction of response to growth hormone treatment in Turner syndrome: the LG Growth Study
  12. Pathogenic/likely pathogenic variants in the SHOX, GHR and IGFALS genes among Indian children with idiopathic short stature
  13. Celiac disease in Saudi children with isolated short stature: is it rare or are we not screening rigorously enough?
  14. The beneficial effect of psychological support on mothers with PKU children who suffer from social discrimination and damage of quality of life
  15. Long-term effects of GnRH agonist treatment on body mass index in girls with idiopathic central precocious puberty
  16. Sudden sex hormone withdrawal and the effects on body composition in late pubertal adolescents with gender dysphoria
  17. The alteration of IGF-1 levels and relationship between IGF-1 levels and growth velocity during GnRH analogue therapy
  18. BMI relationship to the onset of puberty: assessment of growth parameters and sexual maturity changes in Egyptian children and adolescents of both sexes
  19. The effects of a 12-week jump rope exercise program on body composition, insulin sensitivity, and academic self-efficacy in obese adolescent girls
  20. Onset of pituitary hormone deficiencies in optic nerve hypoplasia: a temporal trend analysis of 32 children at Mayo Clinic
  21. Dietary practices in methylmalonic acidaemia: a European survey
  22. Case Reports
  23. Clinical findings in five Turkish patients with citrin deficiency and identification of a novel mutation on SLC25A13
  24. A rare case of primary coenzyme Q10 deficiency due to COQ9 mutation
  25. Sinusitis, an under-reported adverse effect in children treated with radioactive iodine therapy and review of the current literature
  26. Acknowledgment
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