The association of thyroid hormones and blood pressure in euthyroid preadolescents
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Bo Hyun Park
und
Hyesook Park
Abstract
Background: Hypertension is the leading cause of cardiovascular disease worldwide, and both high and low blood pressures are associated with various chronic diseases. Thyroid hormones have profound effects on cardiovascular function, including on blood pressure. Recent studies have shown that childhood hypertension can lead to adult hypertension. Therefore, adequate blood pressure control is important from early life. Employing a life-course approach, we aimed to investigate the association between thyroid hormones and blood pressure in children.
Methods: A total of 290 children from the Ewha Woman’s University Hospital birth cohort participated in a preadolescent check-up program. We assessed the levels of serum thyroid-stimulating hormone (TSH) and free thyroxine (FT4) and the blood pressure status in these children. Thyroid hormone concentrations were measured using an electro-chemiluminescence immunoassay (ECLIA), and hypertension was defined according to the guideline of the Korea Centers for Disease Control and Prevention.
Results: The sex-, age-, and height-adjusted prevalence of hypertension was 27.0% in the present study. On regression analysis, serum FT4 showed significantly negative association with diastolic blood pressure (DBP; β=–8.24, 95% CI: –14.19–2.28, p=0.007). However, these relationships were not significant after adjustment for sex, age, and current body mass index. The levels of serum TSH showed no relationship with mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) after adjustment. No significant differences in serum TSH and FT4 levels according to hypertension status were found.
Conclusions: These findings suggest that thyroid hormone is not independently associated with increased blood pressure in euthyroid preadolescents.
Acknowledgments
This work was supported by a grant from the Korean Society of Pediatric Endocrinology.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2016 by De Gruyter
Artikel in diesem Heft
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Artikel in diesem Heft
- Frontmatter
- Highlight: Vitamin D in Health and Disease
- Vitamin D in health and disease: the global threat of vitamin D deficient rickets
- Effect of 6-months’ vitamin D supplementation on residual beta cell function in children with type 1 diabetes: a case control interventional study
- Low serum sclerostin levels in newborns with vitamin D deficiency
- Vitamin D status in perinatally HIV-infected Thai children receiving antiretroviral therapy
- Efficacy and safety of a single monthly dose of cholecalciferol in healthy school children
- Exposure to sunshine early in life prevented development of type 1 diabetes in Danish boys
- It’s high time to revise Indian guidelines on vitamin D supplementation in children
- Review
- Slipped capital femoral epiphysis and associated hypothyroidism. A review of the literature with two classic case examples
- Original Articles
- Relationship between oxidative stress and blood glucose fluctuations evaluated with daily glucose monitoring in children with type 1 diabetes mellitus
- Association between circulating CCL2 levels and modifiable behaviors in overweight and obese adolescents: a cross-sectional pilot study
- Evaluating health risk using a continuous metabolic syndrome score in obese children
- The association of thyroid hormones and blood pressure in euthyroid preadolescents
- Growth failure in adolescents: etiology, the role of pubertal timing and most useful criteria for diagnostic workup
- New approach to phenotypic variability and karyotype-phenotype correlation in Turner syndrome
- Clinical findings and effect of sodium hydrogen carbonate in patients with glutathione synthetase deficiency
- Maturity onset diabetes of youth (MODY) in Turkish children: sequence analysis of 11 causative genes by next generation sequencing
- Case Reports
- Long-term first line medical treatment in a 4-year-old girl with Xq26.3 microduplication-negative somatotropinoma. Case report and literature review
- Pubertal outcome in a female with virilizing adrenocortical carcinoma
