Vitamin D status in perinatally HIV-infected Thai children receiving antiretroviral therapy
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Linda Aurpibul
Abstract
Background: Low vitamin D level is associated with adverse health outcomes and compromises HIV treatment response. We assess vitamin D status in HIV-infected Thai children receiving combination antiretroviral therapy (cART).
Methods: A cross-sectional study in perinatally HIV-infected children. Vitamin D deficiency and vitamin D insufficiency were defined as serum 25-hydroxyvitamin D (25-OHD) level <20, and 21–29 ng/mL, respectively.
Results: Eighty participants were enrolled. Their median age was 12.2 years. The median CD4 lymphocyte count was 784 cell/mm3; 95% had HIV RNA <50 copies/mL. The median (interquartile range, IQR) 25-OHD level was 33.5 (26.2–39.8) ng/mL. Thirty-four (43%) participants had low vitamin D level; 26 (33%) and 8 (10%) had vitamin D insufficiency and deficiency, respectively. In multivariate analysis, only geographic location was significantly associated with low vitamin D level.
Conclusions: Most of perinatally HIV-infected children receiving cART had low vitamin D level. Calcium and vitamin D supplement might be beneficial.
Acknowledgments
The authors gratefully acknowledge the participation of children and their families, as well as contributions of all study staff at both sites.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2016 by De Gruyter
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Articles in the same Issue
- Frontmatter
- Highlight: Vitamin D in Health and Disease
- Vitamin D in health and disease: the global threat of vitamin D deficient rickets
- Effect of 6-months’ vitamin D supplementation on residual beta cell function in children with type 1 diabetes: a case control interventional study
- Low serum sclerostin levels in newborns with vitamin D deficiency
- Vitamin D status in perinatally HIV-infected Thai children receiving antiretroviral therapy
- Efficacy and safety of a single monthly dose of cholecalciferol in healthy school children
- Exposure to sunshine early in life prevented development of type 1 diabetes in Danish boys
- It’s high time to revise Indian guidelines on vitamin D supplementation in children
- Review
- Slipped capital femoral epiphysis and associated hypothyroidism. A review of the literature with two classic case examples
- Original Articles
- Relationship between oxidative stress and blood glucose fluctuations evaluated with daily glucose monitoring in children with type 1 diabetes mellitus
- Association between circulating CCL2 levels and modifiable behaviors in overweight and obese adolescents: a cross-sectional pilot study
- Evaluating health risk using a continuous metabolic syndrome score in obese children
- The association of thyroid hormones and blood pressure in euthyroid preadolescents
- Growth failure in adolescents: etiology, the role of pubertal timing and most useful criteria for diagnostic workup
- New approach to phenotypic variability and karyotype-phenotype correlation in Turner syndrome
- Clinical findings and effect of sodium hydrogen carbonate in patients with glutathione synthetase deficiency
- Maturity onset diabetes of youth (MODY) in Turkish children: sequence analysis of 11 causative genes by next generation sequencing
- Case Reports
- Long-term first line medical treatment in a 4-year-old girl with Xq26.3 microduplication-negative somatotropinoma. Case report and literature review
- Pubertal outcome in a female with virilizing adrenocortical carcinoma
