Ethnopharmacological approaches in mood and anxiety disorders. The relevance of the oxidative stress status
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Simplice Harquin Foyet
Abstract
Neurodegenerative diseases and psychiatric disorders are one of the most important pathologies that lead to increased morbidity in populations. Both mood and anxiety disorders include mental disorders not caused by detectable organic abnormalities of the brain. At the molecular level, affective spectrum symptomatology is due to neurotransmitter dysregulation including receptor or transporter impairments and also due to faulty intracellular signaling that generally leads to impaired neurotransmission. Also, recent studies have shown the relationship between oxidative stress and the development of affective disorders. Since classical medication can cause major side effects and alternative approaches tend to be more and more trusted, it seems that plant extracts-based complementary therapies may offer superior yielding and safety compared to traditional medication.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: Ioana-Miruna Balmus was co-funded by the European Social Fund through Sectorial Operational Program of Human Resources Development 2007 – 2013, project number POSDRU/187/1.5/S/155397, project title “Towards a New Generation of Elite Researchers through Doctoral Scholarships” during the work for this review. Ciobica Alin and Miruna Balmus are supported by a PN II Research Grant no. PN-II-RU-TE-2014-4-1886, called “A Complex Study regarding the Relevance of Oxytocin Administration in Some Animal Models of Neuropsychiatric Disorders.”
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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Artikel in diesem Heft
- Review
- Ethnopharmacological approaches in mood and anxiety disorders. The relevance of the oxidative stress status
- Preclinical Studies
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- Preliminary phytochemical analysis and evaluation of antioxidant, cytotoxic and inhibition of lipopolysaccaride - induced NOS (iNOS) expression in BALB/c mice liver by Ziziphus oenoplia Mill. fruit
- Evaluation of the sub-chronic toxicity profile of the corm of Xanthosoma sagittifolium on hematology and biochemistry of alloxan-induced diabetic Wistar rats
- Dendrobium chrysanthum ethanolic extract induces apoptosis via p53 up-regulation in HeLa cells and inhibits tumor progression in mice
- Safety assessment of the aqueous extract of the flowers of Nymphaea lotus Linn (Nymphaeaceae): Acute, neuro- and subchronic oral toxicity studies in albinos Wistar rats
- Effect of aqueous extract of Aegle marmelos fruit and leaf on glycemic, insulinemic and lipidemic status of type 2 diabetic model rats
- Antihypernociceptive and antioxidant effects of Petersianthus macrocarpus stem bark extracts in rats with complete Freund’s adjuvant-induced persistent inflammatory pain
- ROS-mediated induction of apoptosis by benzoquinone embelin in human colon adenocarcinoma cells HT-29
- Clinical Studies
- Desensitization to chemical and food sensitivities by low-dose immunotherapy ascertained by provocation neutralization is associated with reduced influx of calcium ions into lymphocytes
- Managing irritable bowel syndrome: The impact of micro-physiotherapy
- Short Communication
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Artikel in diesem Heft
- Review
- Ethnopharmacological approaches in mood and anxiety disorders. The relevance of the oxidative stress status
- Preclinical Studies
- Cytokine changes in gastric and colonic epithelial cell in response to Planta ovata extract
- Preliminary phytochemical analysis and evaluation of antioxidant, cytotoxic and inhibition of lipopolysaccaride - induced NOS (iNOS) expression in BALB/c mice liver by Ziziphus oenoplia Mill. fruit
- Evaluation of the sub-chronic toxicity profile of the corm of Xanthosoma sagittifolium on hematology and biochemistry of alloxan-induced diabetic Wistar rats
- Dendrobium chrysanthum ethanolic extract induces apoptosis via p53 up-regulation in HeLa cells and inhibits tumor progression in mice
- Safety assessment of the aqueous extract of the flowers of Nymphaea lotus Linn (Nymphaeaceae): Acute, neuro- and subchronic oral toxicity studies in albinos Wistar rats
- Effect of aqueous extract of Aegle marmelos fruit and leaf on glycemic, insulinemic and lipidemic status of type 2 diabetic model rats
- Antihypernociceptive and antioxidant effects of Petersianthus macrocarpus stem bark extracts in rats with complete Freund’s adjuvant-induced persistent inflammatory pain
- ROS-mediated induction of apoptosis by benzoquinone embelin in human colon adenocarcinoma cells HT-29
- Clinical Studies
- Desensitization to chemical and food sensitivities by low-dose immunotherapy ascertained by provocation neutralization is associated with reduced influx of calcium ions into lymphocytes
- Managing irritable bowel syndrome: The impact of micro-physiotherapy
- Short Communication
- Design development and evaluation of triphala tablets