A hypothesis that Notopterol may be effective in COVID-19 via JAK/STAT and other signaling pathways
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Fereshteh Nazari-Khanamiri
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Morteza Ghasemnejad-Berenji
Abstract
COVID-19 is a rapidly spreading disease, causing a global pandemic. It is circulating in multiple countries and causing a series of respiratory infections. Due to the uncertain safety and efficacy of the vaccines and lack of specific medicines, it’s important to investigate new pharmacological procedures and find out new drugs that help us eradicate this pandemic. We suggest the hypothesis that Notopterol (NOT), the main Secondary metabolite of Notopterygium incisum Ting ex H.T (a common Chinese medicinal herb), may have the potential benefits on SARS-CoV2 infection for this reasons: (a) NOT exhibits anti-inflammatory, anticancer, and anti-angiogenic properties, (b) NOT indicates a significant reduction in cytokines and chemokines releasing including TNFa, IL-6, interferon-γ, which may decrease COVID-19 cytokine storm (c) NOT can suppress the expression of genes which leads to inflammation via Janus kinase/signal transducers and activators of transcription (JAK-STAT) signaling pathway. It is exactly acting like tocilizumab, (an approved drug against COVID-19) and (d) Notopterygium incisum has antiviral activity against influenza virus, it can reduce the viral-induced oxidative stress. By these explanations, it is hopeful that NOT may be effective in COVID-19 infections which needs further investigations to examine Notopterol as a beneficial agent against the SARS-CoV2 infection.
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Research funding: There is no funding.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
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Informed consent: Informed consent was obtained from all individuals included in this study.
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Ethical approval: The local Institutional Review Board deemed the study exempt from review.
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© 2022 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
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Artikel in diesem Heft
- Frontmatter
- Editorial
- Investigating periprostatic adipose tissue as a driving force of prostate cancer progression: a new source of information for the advancement of targeted therapy in metastatic prostate cancer
- Reviews
- Pathophysiological effects of cadmium(II) on human health-a critical review
- The role of synbiotics in improving inflammatory status in nasopharyngeal carcinoma patients
- Anti-ageing effects of FDA-approved medicines: a focused review
- Diagnosis and management of uterine fibroids: current trends and future strategies
- Importance of moderate-to-vigorous physical activity during the COVID-19 pandemic: a systematic review and meta-analysis
- Original Articles
- Healthcare workers’ knowledge of evidence-based guidelines for prevention of ventilator-associated pneumonia in Hodeida, Yemen
- Comparison of cardiac autonomic function across complete glycaemic spectrum
- Prognostic value of heart rate variability in acute coronary syndrome
- Insights into the protective capacity of human dental pulp stem cells and its secretome in cisplatin-induced nephrotoxicity: effects on oxidative stress and histological changes
- Caffeine impairs anticonvulsant effects of levetiracetam in the maximal electroshock seizure threshold test in mice
- Antioxidant activity in off and on-pump coronary artery bypass grafting and valve replacement surgery
- A drug utilisation pattern in non-dialysis patients of diabetic nephropathy in a government-run tertiary care hospital in South-Asia
- Inguinal lymphadenectomy in penile cancer patients: a comparison between open and video endoscopic approach in a multicenter setting
- A randomized controlled trial to evaluate the efficacy of electrical vestibular nerve stimulation (VeNS), compared to a sham control for the management of sleep in young adults
- Short Communication
- The role of Bruton’s kinase inhibitors (BTKi) in accelerated Chronic Lymphocytic Leukemia (a-CLL): a case of successful response to acalabrutinib
- Letter to the Editor
- A hypothesis that Notopterol may be effective in COVID-19 via JAK/STAT and other signaling pathways
