A case of statin-induced liver injury with positive rechallenge with a second statin. Is there a class effect?
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Giovanna Onfiani
,
Fabio Nascimbeni
Abstract
Objectives
Statins have proved to reduce cardiovascular morbidity and mortality in high-risk population and are generally well tolerated, although adverse events can occur. Up to 3% of patients develop aminotransferases elevation, which usually normalizes with continued treatment and hardly is associated with clinical symptoms. Serious statin-related liver injury is exceedingly rare. Furthermore, literature regarding rechallenge with a second statin is extremely poor. Some authors caution that re-exposure to these drugs is associated with a more serious liver injury but safe switching to a second statin after drug-induced liver injury (DILI) is also reported.
Case presentation
We describe a case of a middle-aged woman who developed hepatocellular liver injury after simvastatin dose escalation; a rechallenge with low dose rosuvastatin caused rapid recurrence of DILI.
Conclusions
In our opinion, clinicians should be very cautious upon rechallenge and closely follow-up patients who experienced statin-induced liver injury when trying re-exposure to another statin.
Acknowledgments
Not applicable.
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Research funding: None declared.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest with respect to this manuscript. Outside the submitted work, FC received research-travel reimbursement by Sanofi, Amicus, Mylan, Sanofi-Genzyme, Shire-Takeda.
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Informed consent: Informed consent was obtained from all individuals included in this study.
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Ethical approval: Not applicable.
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Artikel in diesem Heft
- Frontmatter
- Review
- Historical account of endocrinal disorders in Unani medicine
- Original Articles
- Impact of sleep disturbances and autonomic dysfunction on the quality of life of patients with fibromyalgia
- Effects of date seeds administration on anxiety and depressive symptoms in streptozotocin-induced diabetic rats: biochemical and behavioral evidences
- Piroxicam reduces acute and chronic pain response in type 1 diabetic rats
- Protective effect of Elateriospermum tapos in maternal obesity-induced deficit cognitive function of the offspring
- Pharmacological investigations on efficacy of Phlorizin a sodium-glucose co-transporter (SGLT) inhibitor in mouse model of intracerebroventricular streptozotocin induced dementia of AD type
- Concurrent administration of acetaminophen and ethanol: impact on mouse liver and testis
- Electrical vestibular nerve stimulation as an adjunctive therapy in the management of type 2 diabetes
- Effect of roxithromycin on contractile activity of gastrointestinal smooth muscles in colitic rats
- Anti-inflammatory and analgesic effects of methanol extract of red cultivar Allium cepa bulbs in rats and mice
- Prophylactic effect of aquatic extract of stevia on acetic acid induced-ulcerative colitis in male rats: a possible role of Nrf2 and PPARγ
- Molecular docking study of flavonoid compounds for possible matrix metalloproteinase-13 inhibition
- Inhibition of key enzymes linked to snake venom induced local tissue damage by kolaviron
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- Case Report
- A case of statin-induced liver injury with positive rechallenge with a second statin. Is there a class effect?
