The effect of thyroid dysfunction on nesfatin-1 and adiponectin levels in rats
-
Emine Atıci
,
Abdulkerim Kasım Baltaci
Abstract
Background
Changes in thyroid hormone concentrations may affect adiponectin concentrations through various mechanisms. A molecule released primarily from the fat cells adiposities; adiponectin has important effects on the regulation of body weight.
Aim
The present study aimed to explore the effects of experimental thyroid dysfunction and its treatment on nesfatin-1 and adiponectin levels in rats.
Methods
The study included 40 adult male Sprague-Dawley rats which were grouped as follows: (1) control; (2) hypothyroidism [hypothyroidism was induced by intraperitoneal injection of 10 mg/kg/day propylthiouracil (PTU) for 3 weeks]; (3) hypothyroidism + thyroxine group [after hypothyroidism was induced by 2-week PTU injection, they were treated with high-dose L-thyroxine (1.5 mg/kg/day) for 1 week]; (4) hyperthyroidism [hyperthyroidism was induced by 3-weeks’ thyroxine injection (0.3 mg/kg/day)]; (5) hyperthyroidism + PTU (after hyperthyroidism was induced by 2-weeks’ thyroxine injection, the animals were given 10 mg/kg/day PTU for 1 week). Blood samples taken at the end of the study were analyzed to measure nesfatin-1 and adiponectin levels.
Results
It was found that nesfatin-1 levels increased in hypothyroidism, while adiponectin levels decreased (p < 0.001). In experimental hyperthyroidism, on the other hand, both nesfatin-1 and adiponectin levels were found significantly elevated (p < 0.001).
Conclusion
The results of the study indicate that nesfatin-1 and adiponectin levels were modified considerably in hypo- and hyperthyroidism, whereas with the restoration of the thyroid function, modified hormone levels went back to normal.
Author Statement
Research funding: This study was supported by a grant Selcuk University, Scientific Research Council (Grant number is 14202034).
Conflict of interest: Authors state no conflict of interest.
Informed consent: Informed consent was not applicable.
Ethical approval: An application was made to the Ethical Committee for Experimental Research on Animals of Baskent University’s School of Medicine for the evaluation of the conformity of the study with ethical principles, and the approval of the committee was received by the document number DA/14 27.
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Artikel in diesem Heft
- Review Articles
- Tumor-linked HER2 expression: association with obesity and lipid-related microenvironment
- The functional significance of 14-3-3 proteins in cancer: focus on lung cancer
- Original Articles
- The effect of thyroid dysfunction on nesfatin-1 and adiponectin levels in rats
- Back pain in pregnancy among office workers: risk factors and its impact on quality of life
- Do exercises improve back pain in pregnancy?
- Case Report
- Ectopic adrenal tissue associated with borderline mucinous cystadenoma of ovary: a case report with review of the literature
