Optimization of hydrogel composition for effective release of drug
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R. K. Pavan Kumar Pannala
Abstract
Hydrogels are possible materials that could be useful in medication delivery systems. Diverse release mechanisms are used when drug molecules embedded in the hydrogel structure need to be released. Both case I and case II of transport refer to the release of the medication during the intermolecular arrangement because of swelling. Numerous mathematical models have been proposed that only include one form of transport; nevertheless, both transport pathways are required for the entire release of a drug from a gel matrix. The case I transport during swelling and the case II transport during the fully swollen condition are both displayed by crosslinked hyaluronic acid hydrogel systems. The methodology put out in this paper enables for the selection of suitable gel compositions while attempting to account for both transit instances. In the Data Envelopment Analysis coupled with principal component analysis approaches are enable the optimization and selection of gel compositions that account for both transport situations.
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Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
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Research funding: None declared.
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Conflict of interest statement: The authors declare no conflicts of interest regarding this article.
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Artikel in diesem Heft
- Frontmatter
- Research Articles
- Tuning of PID controllers for unstable first-order plus dead time systems
- Oxygen excess ratio control of PEM fuel cell: fractional order modeling and fractional filter IMC-PID control
- Proposal and energy/exergy/economic analyses of a smart heat recovery for distillation tower of the Naphtha Hydrotreating Unit of the Petrochemical Plant; designing a low-carbon plant
- Three-dimensional CFD study on thermo-hydraulic behaviour of finned tubes in a heat exchange system for heat transfer enhancement
- A simulation and thermodynamic improvement of the methanol production process with economic analysis: natural gas vapor reforming and utilization of carbon capture
- Optimization of hydrogel composition for effective release of drug
- Mathematical modelling of water-based biogas scrubber operating at digester pressure
- COCO, a process simulator: methane oxidation simulation & its agreement with commercial simulator’s predictions
- Hydrodynamics of shear thinning fluid in a square microchannel: a numerical approach
- Parameter estimation in non-linear chemical processes: an opposite point-based differential evolution (OPDE) approach
Artikel in diesem Heft
- Frontmatter
- Research Articles
- Tuning of PID controllers for unstable first-order plus dead time systems
- Oxygen excess ratio control of PEM fuel cell: fractional order modeling and fractional filter IMC-PID control
- Proposal and energy/exergy/economic analyses of a smart heat recovery for distillation tower of the Naphtha Hydrotreating Unit of the Petrochemical Plant; designing a low-carbon plant
- Three-dimensional CFD study on thermo-hydraulic behaviour of finned tubes in a heat exchange system for heat transfer enhancement
- A simulation and thermodynamic improvement of the methanol production process with economic analysis: natural gas vapor reforming and utilization of carbon capture
- Optimization of hydrogel composition for effective release of drug
- Mathematical modelling of water-based biogas scrubber operating at digester pressure
- COCO, a process simulator: methane oxidation simulation & its agreement with commercial simulator’s predictions
- Hydrodynamics of shear thinning fluid in a square microchannel: a numerical approach
- Parameter estimation in non-linear chemical processes: an opposite point-based differential evolution (OPDE) approach
