Prostaglandin induced cortical hyperostosis in neonates with cyanotic heart disease
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A. M. Nadroo
Abstract
Objective: To study the side effects of prolonged prostaglandin therapy especially hyperostosis and other musculoskeletal changes.
Methods: Case files of the neonates, with cyanotic heart disease, who had received prostaglandin infusion from early days of life, were reviewed. Patients with periosteal changes were identified. Their radiographs, serum alkaline phosphatase activity, duration and dose of prostaglandin and other side effects related to the prostaglandin were studied.
Results: Ten patients developed hyperostosis, who had received PGE1 infusion for a period of 9 to 195 days. Two babies developed coarse facial features, hypertrichosis, and edema of extremities and digital swelling. Serum alkaline phosphatase activity was significantly raised in the patients, with hyperostosis. Besides long bones, ribs and scapulae, the clavicles were also involved. The involvement of clavicles has not been previously reported.
Conclusion: Hyperostosis is a common side effect of prolonged prostaglandin therapy. Abnormal facial features, hypertrichosis and coarse skin are additional adverse effects of long term therapy. Serum alkaline phosphatase activity can be used as a marker of the hyperostosis. In addition to other bones clavicles can also be involved. The above effects seem to be both dose and duration dependent.
Copyright (c)2000 by Walter de Gruyter GmbH & Co. KG
Artikel in diesem Heft
- Author Index
- Subject Index
- Contents
- Ellis van Creveld syndrome (chondroectodermal dysplasia, MIM 22550) in three siblings from a non-consanguineous mating
- Effect of maternal weight gain on infant birth weight
- Neonatal echocardiograms of macrosomic neonates
- Effects of surfactant treatment on gas-exchange and clinical course in near-term newborns with RDS
- Adolescent pregnancy: positive perinatal outcome at a community hospital
- Prostaglandin induced cortical hyperostosis in neonates with cyanotic heart disease
- Management of cervical cerclage at term: remove the suture in labor?
- Expedited human immunodeficiency virus testing of mothers and new-borns with unknown HIV status at time of labor and delivery
- The pathogenesis of pre-eclampsia: new aspects
- Peripartum hysterectomy
- Wishes and expectations of pregnant women and their partners concerning delivery
- Prevalence and risk factors for prelabor rupture of the membranes (PROM) at or near term in an urban Swedish population
- “Shake hands”; Diagnosing a floppy infant – Myotonic dystrophy and the congenital subtype: a difficult perinatal diagnosis
- Effect of corticosteroids on HELLP syndrome: a case report
Artikel in diesem Heft
- Author Index
- Subject Index
- Contents
- Ellis van Creveld syndrome (chondroectodermal dysplasia, MIM 22550) in three siblings from a non-consanguineous mating
- Effect of maternal weight gain on infant birth weight
- Neonatal echocardiograms of macrosomic neonates
- Effects of surfactant treatment on gas-exchange and clinical course in near-term newborns with RDS
- Adolescent pregnancy: positive perinatal outcome at a community hospital
- Prostaglandin induced cortical hyperostosis in neonates with cyanotic heart disease
- Management of cervical cerclage at term: remove the suture in labor?
- Expedited human immunodeficiency virus testing of mothers and new-borns with unknown HIV status at time of labor and delivery
- The pathogenesis of pre-eclampsia: new aspects
- Peripartum hysterectomy
- Wishes and expectations of pregnant women and their partners concerning delivery
- Prevalence and risk factors for prelabor rupture of the membranes (PROM) at or near term in an urban Swedish population
- “Shake hands”; Diagnosing a floppy infant – Myotonic dystrophy and the congenital subtype: a difficult perinatal diagnosis
- Effect of corticosteroids on HELLP syndrome: a case report
