Effects of surfactant treatment on gas-exchange and clinical course in near-term newborns with RDS
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S. G. Golombek
Abstract
Objective: To determine if there is a relationship between acute improvement in pulmonary gas exchange and surfactant use in near-term (35–39 weeks' gestation) infants with respiratory distress syndrome (RDS).
Methods: We examined retrospectively the records of 54 infants admitted during a 15 month period who were 35 or more weeks of gestation, and who demonstrated all the diagnostic features of RDS. Data analyzed included: birth weight; gestational age; Apgar scores; calculated alveolar to arterial oxygen gradient (AaDO2) and oxygenation index (0I); hours of life at intubation; surfactant administration; complications with surfactant administration; use of inotropic medications.
Results: A total of 30 of infants were treated with intubation and surfactant administration. Mean FiO2 at the time of surfactant administration was 0.96. The AaDO2 decreased from 64.0 ± 14.8 kPa to 41.8 ± 22.5 kPa by 6 hrs (p < 0.0001). There was no relationship between age at treatment (6–89 hr) and response to treatment as measured by changes in AaDO2, FiO2, or oxygenation index (OI).
Conclusions: Near-term infants with severe RDS often respond to exogenous surfactant, suggesting a functional deficiency of endogenous surfactant at a “late” stage in their disease process.
We speculate that delayed treatment may still be effective in these patients.
Copyright (c)2000 by Walter de Gruyter GmbH & Co. KG
Articles in the same Issue
- Author Index
- Subject Index
- Contents
- Ellis van Creveld syndrome (chondroectodermal dysplasia, MIM 22550) in three siblings from a non-consanguineous mating
- Effect of maternal weight gain on infant birth weight
- Neonatal echocardiograms of macrosomic neonates
- Effects of surfactant treatment on gas-exchange and clinical course in near-term newborns with RDS
- Adolescent pregnancy: positive perinatal outcome at a community hospital
- Prostaglandin induced cortical hyperostosis in neonates with cyanotic heart disease
- Management of cervical cerclage at term: remove the suture in labor?
- Expedited human immunodeficiency virus testing of mothers and new-borns with unknown HIV status at time of labor and delivery
- The pathogenesis of pre-eclampsia: new aspects
- Peripartum hysterectomy
- Wishes and expectations of pregnant women and their partners concerning delivery
- Prevalence and risk factors for prelabor rupture of the membranes (PROM) at or near term in an urban Swedish population
- “Shake hands”; Diagnosing a floppy infant – Myotonic dystrophy and the congenital subtype: a difficult perinatal diagnosis
- Effect of corticosteroids on HELLP syndrome: a case report
Articles in the same Issue
- Author Index
- Subject Index
- Contents
- Ellis van Creveld syndrome (chondroectodermal dysplasia, MIM 22550) in three siblings from a non-consanguineous mating
- Effect of maternal weight gain on infant birth weight
- Neonatal echocardiograms of macrosomic neonates
- Effects of surfactant treatment on gas-exchange and clinical course in near-term newborns with RDS
- Adolescent pregnancy: positive perinatal outcome at a community hospital
- Prostaglandin induced cortical hyperostosis in neonates with cyanotic heart disease
- Management of cervical cerclage at term: remove the suture in labor?
- Expedited human immunodeficiency virus testing of mothers and new-borns with unknown HIV status at time of labor and delivery
- The pathogenesis of pre-eclampsia: new aspects
- Peripartum hysterectomy
- Wishes and expectations of pregnant women and their partners concerning delivery
- Prevalence and risk factors for prelabor rupture of the membranes (PROM) at or near term in an urban Swedish population
- “Shake hands”; Diagnosing a floppy infant – Myotonic dystrophy and the congenital subtype: a difficult perinatal diagnosis
- Effect of corticosteroids on HELLP syndrome: a case report
