Startseite Medizin Lipid transfer protein activities in subjects with impaired glucose tolerance
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Lipid transfer protein activities in subjects with impaired glucose tolerance

  • Ulrich Julius , Matti Jauhiainen , Christian Ehnholm und Jens Pietzsch
Veröffentlicht/Copyright: 20. Februar 2007
Clinical Chemistry and Laboratory Medicine (CCLM)
Aus der Zeitschrift Band 45 Heft 2

Abstract

Background: Impaired glucose tolerance (IGT) is associated with an increased risk of atherosclerosis that may be due in part to dyslipidemia. The purpose of this study was to assess the regulatory role of lipid transfer proteins in the development of this dyslipidemia.

Methods: Activities of cholesterol ester transfer protein (CETP) and phospholipid transfer protein (PLTP), as well as lipid and protein components of the major lipoprotein fractions, were evaluated in probands with IGT and were compared with those in subjects with normal glucose tolerance. The effect of a fat-rich meal on these variables was also investigated.

Results: IGT probands had a higher triglyceride content in subfractions of low- (LDL) and high-density lipoprotein (HDL). IGT patients had higher fasting CETP activity. The latter was positively correlated with HDL2 triglycerides and negatively with HDL3 total cholesterol. PLTP activity and mass were not higher in IGT patients. However, PLTP activity correlated with components of VLDL and LDL and was influenced by the type of obesity. Neither CETP and PLTP activities nor PLTP mass were altered by a fat-rich meal. PLTP and CETP activities correlated in both fasting and postprandial conditions.

Conclusions: Increased fasting CETP activity may contribute to increased risk of atherosclerosis in subjects with IGT.

Clin Chem Lab Med 2007;45:237–43.

Keywords: cholesterol ester transfer protein; impaired glucose tolerance; oral fat loading test; oral glucose tolerance test; phospholipid transfer protein
:
Corresponding author: Prof. Dr. Ulrich Julius, Medizinische Klinik und Poliklinik III, Universitätsklinikum Dresden, Fetscherstr. 74, 01307 Dresden, Germany Phone: +49-351-4582306, Fax: +49-351-4585306,

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Published Online: 2007-02-20
Published in Print: 2007-02-01

©2007 by Walter de Gruyter Berlin New York

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https://doi.org/10.1515/CCLM.2007.032
Schlagwörter für diesen Artikel
cholesterol ester transfer protein; impaired glucose tolerance; oral fat loading test; oral glucose tolerance test; phospholipid transfer protein

Artikel in diesem Heft

  1. Associations between folate, vitamin B12, homocysteine and pathologies related to aging: the need to consider complex nutrient-nutrient and gene-nutrient interactions and the functional and socio-economic determinants in population-based studies
  2. Hyperhomocysteinemia and cardiovascular risk in postmenopausal women: the role of folate supplementation
  3. Association of vitamin B12, folate and homocysteine with functional and pathological characteristics of the elderly in a mountainous village in Sicily
  4. Association of thyroid dysfunction with vitamin B12, folate and plasma homocysteine levels in the elderly: a population-based study in Sicily
  5. Desmond (Des) Kenny MSc MCB FICI FRCPath Eur Clin Chem, 1941–2006
  6. Antibodies to citrullinated peptides: a significant step forward in the early diagnosis of rheumatoid arthritis
  7. Patient hydration: a major source of laboratory uncertainty
  8. Determination of the hepatitis C virus subtype: comparison of sequencing and reverse hybridization assays
  9. Quantification of relative changes in specific mRNAs from frozen whole blood – methodological considerations and clinical implications
  10. HER-2 protein concentrations in breast cancer cells increase before immunohistochemical and fluorescence in situ hybridization analysis turn positive
  11. Distinct alleles of mannose-binding lectin (MBL) and surfactant proteins A (SP-A) in patients with chronic cavitary pulmonary aspergillosis and allergic bronchopulmonary aspergillosis
  12. Novel molecular defect in the platelet ADP receptor P2Y12 of a patient with haemorrhagic diathesis
  13. Retrospective study of monoclonal gammopathies detected in the clinical laboratory of a Spanish healthcare district: 14-year series
  14. Renal impairment compromises the use of total homocysteine and methylmalonic acid but not total vitamin B12 and holotranscobalamin in screening for vitamin B12 deficiency in the aged
  15. Diagnostic value of calculated testosterone indices in the assessment of polycystic ovary syndrome
  16. Amniotic fibronectin fragmentation and expression of its domains, sialyl and fucosyl glycotopes associated with pregnancy complicated by intrauterine infection
  17. Predicted influence of sample hematocrit on injected mass of internal standard in mass spectrometry assays utilizing simple protein precipitation for sample preparation
  18. Evaluation of cardiovascular risk factors and related clinical markers in healthy young Japanese adults
  19. Cardiac natriuretic peptides after myocardial infarction: relationship with infarct size, left ventricular function and remodelling assessed by 99mTc-sestamibi gated-single photon emission tomography
  20. Plasma homocysteine cutoff values for venous thrombosis
  21. Lipid transfer protein activities in subjects with impaired glucose tolerance
  22. Heat shock protein 70-1 gene expression in pediatric heart surgery using blood cardioplegia
  23. Biochemical reference intervals for sex hormones with a new AutoDelfia method in aged men
  24. The Italian External Quality Control Programme for cystic fibrosis molecular diagnosis: 4 years of activity
  25. Standardization of ischemia-modified albumin testing: adjustment for serum albumin
  26. Is simultaneous measurement of anti-thyroid peroxidase and anti-thyroglobulin antibodies clinically useful in patients with thyroid dysfunction?
  27. To the Editor: In reply to Nakano et al. Clin Chem Lab Med 2006;44(5):522–532
  28. To the Editor: Author reply; Nakano et al. Clin Chem Lab Med 2006;44(5):522–532
  29. Accreditation of medical laboratories in the European Union
  30. Prevalence-dependent decision limits for the early detection of type 2 diabetes mellitus in venous blood, venous plasma and capillary blood during glucose challenge
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