Antiviral activity of a sulfoquinovosyldiacylglycerol (SQDG) compound isolated from the green alga Caulerpa racemosa
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Hui Wang
Abstract
An invasive green alga, Caulerpa racemosa, collected from the South China Sea was tested for its antiviral properties. Hot water extracts and the n-butanol fraction obtained showed potent inhibition of herpes simplex virus type 1 (HSV-1) and Coxsackie virus B3 (Cox B3). A sulfoquinovosyldiacylglycerol (SQDG) compound was isolated and purified from the n-butanol fraction following further antiviral-guided fractionation. The SQDG compound exhibited an excellent antiviral effect against HSV-2, with a 50% inhibitory concentration (IC50) of 15.6 μg ml-1 against both standard and clinical strains of HSV-2, but showed only moderate antiviral effects against HSV-1 and Cox B3. The SQDG compound was chemically characterized using spectroscopic methods as (2S)-1,2-di-O-palmitoyl-3-O-(6′-sulfo-α-D-quinovopyranosyl) glycerol. This is the first isolation from C. racemosa of this SQDG compound with notable selective antiviral activity against HSV-2.
©2007 by Walter de Gruyter Berlin New York
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Artikel in diesem Heft
- Native eelgrass (Zostera marina L.) survival and growth adjacent to non-native oysters (Crassostrea gigas Thunberg) in the Strait of Georgia, British Columbia
- Heavy metal biomonitoring by seaweeds on the Delmarva Peninsula, east coast of the USA
- Morphological and genetic variation in Egregia menziesii over a latitudinal gradient
- An improved method for staining chromosomes of marine algae
- Characterization of Gracilaria lemaneiformis Bory (Gracilariaceae, Rhodophyta) cultivars in China using the total soluble proteins and RAPD analysis
- Antiviral activity of a sulfoquinovosyldiacylglycerol (SQDG) compound isolated from the green alga Caulerpa racemosa
- Seasonal variations in the composition and gel quality of agar from Gracilaria edulis in the Philippines
- Meetings
