14 Physicochemical and free radical scavenging activity of Adansonia digitata seed oil
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Emmanuel Mshelia Halilu
Abstract
Adansonia digitata is used in folk medicine as antipyretic, analgesic and as an antioxidant. The aim of the research was to study the physicochemical, antioxidant and acute toxicity profiles of the oil extracted from the seed nuts. Standard methods were used to ascertain the physicochemical parameters, antioxidant properties and the oral acute toxicity. The moisture content (MC), total ash (TA), acid insoluble ash (AIA), alcohol soluble extractive (ASE) and the water-soluble extractive (WSE) were: 4 %, 4 %, 0.33 %, 22 % and 20.67 % respectively. The oil yielded 15.29 %. The GC-MS revealed some fatty acids/esters. The oil was soluble in varieties organic solvents including petroleum ether, benzene, chloroform and others. Steroids were detected in the oil through qualitative phytochemical screening. The saponification value (SV) of 30.86 mgKOH/g, acid value (AV) of 140.25 mgKOH/g, Ester value (EV) of 109.39 mgKOH/g, iodine value (IV) of 104.05 gI2/ 100 g and specific gravity (SG) of 0.92 were obtained. The oil was safe up to a dose of 5000 mg/kg per body weight via the oral route at one dose level. The DPPH free radical scavenging activity of the oil showed the highest inhibition (92.3 %) at 3.30 mg/mL and the least inhibition of 86.6 % at 0.12 mg/mL. Therefore, this research has revealed that Adansonia digitata oil contain phytochemicals with free radical scavenging properties and the oil is not toxic.
Abstract
Adansonia digitata is used in folk medicine as antipyretic, analgesic and as an antioxidant. The aim of the research was to study the physicochemical, antioxidant and acute toxicity profiles of the oil extracted from the seed nuts. Standard methods were used to ascertain the physicochemical parameters, antioxidant properties and the oral acute toxicity. The moisture content (MC), total ash (TA), acid insoluble ash (AIA), alcohol soluble extractive (ASE) and the water-soluble extractive (WSE) were: 4 %, 4 %, 0.33 %, 22 % and 20.67 % respectively. The oil yielded 15.29 %. The GC-MS revealed some fatty acids/esters. The oil was soluble in varieties organic solvents including petroleum ether, benzene, chloroform and others. Steroids were detected in the oil through qualitative phytochemical screening. The saponification value (SV) of 30.86 mgKOH/g, acid value (AV) of 140.25 mgKOH/g, Ester value (EV) of 109.39 mgKOH/g, iodine value (IV) of 104.05 gI2/ 100 g and specific gravity (SG) of 0.92 were obtained. The oil was safe up to a dose of 5000 mg/kg per body weight via the oral route at one dose level. The DPPH free radical scavenging activity of the oil showed the highest inhibition (92.3 %) at 3.30 mg/mL and the least inhibition of 86.6 % at 0.12 mg/mL. Therefore, this research has revealed that Adansonia digitata oil contain phytochemicals with free radical scavenging properties and the oil is not toxic.
Kapitel in diesem Buch
- Frontmatter I
- Preface of the Book of Proceedings of the Virtual Conference on Chemistry and its Applications (VCCA-2022). V
- Contents VII
- List of contributing authors XIX
- 1 Dipeptidyl peptidase IV: a multifunctional enzyme with implications in several pathologies including cancer 1
- 2 A mini review on the prospects of Fagara zanthoxyloides extract based composites: a remedy for COVID-19 and associated replica? 57
- 3 Triterpenoids of antibacterial extracts from the leaves of Bersama abyssinica Fresen (Francoaceae) 75
- 4 Physicochemical assessment and insilico studies on the interaction of 5-HT2c receptor with herbal medication bioactive compounds used in the treatment of premature ejaculation 87
- 5 Xanthoangelol, geranilated chalcone compound, isolation from pudau leaves (Artocarpus kemando Miq.) as antibacterial and anticancer 121
- 6 Exploration of bioactive compounds from Mangifera indica (Mango) as probable inhibitors of thymidylate synthase and nuclear factor kappa-B (NF-Κb) in colorectal cancer management 137
- 7 Identification of potential inhibitors of thymidylate synthase (TS) (PDB ID: 6QXH) and nuclear factor kappa-B (NF–κB) (PDB ID: 1A3Q) from Capsicum annuum (bell pepper) towards the development of new therapeutic drugs against colorectal cancer (CRC) 165
- 8 Synthesis, characterization and in vitro activity study of some organotin(IV) carboxylates against leukemia cancer cell, L-1210 199
- 9 Phytochemicals from Annona muricata (Sour Sop) as potential inhibitors of SARS-CoV-2 main protease (Mpro) and spike receptor protein: a structure-based drug design studies and chemoinformatics analyses 207
- 10 Identification of novel inhibitors of P13K/AKT pathways: an integrated in-silico study towards the development of a new therapeutic agent against ovarian cancer 231
- 11 Immobilization of α-amylase from Aspergillus fumigatus using adsorption method onto zeolite 261
- 12 Phytochemical components and GC–MS analysis of Petiveria alliaceae L. fractions and volatile oils 273
- 13 Characterization of crude saponins from stem bark extract of Parinari curatellifolia and evaluation of its antioxidant and antibacterial activities 287
- 14 Physicochemical and free radical scavenging activity of Adansonia digitata seed oil 307
- 15 Photoprotection strategies with antioxidant extracts: a new vision 321
- 16 A systematic DFT study of arsenic doped iron cluster AsFen (n = 1–4) 335
- 17 Effect of case-based learning, team-based learning and regular teaching methods on secondary school students’ self-concept in chemistry in Maara sub-county, Tharaka Nithi county, Kenya 345
- 18 Random and block architectures of N-arylitaconimide monomers with methyl methacrylate 359
- 19 Evaluation of phytochemicals and amino acid profiles of four vegetables grown on a glyphosate contaminated soil in Southwestern Nigeria 399
- Index 411
Kapitel in diesem Buch
- Frontmatter I
- Preface of the Book of Proceedings of the Virtual Conference on Chemistry and its Applications (VCCA-2022). V
- Contents VII
- List of contributing authors XIX
- 1 Dipeptidyl peptidase IV: a multifunctional enzyme with implications in several pathologies including cancer 1
- 2 A mini review on the prospects of Fagara zanthoxyloides extract based composites: a remedy for COVID-19 and associated replica? 57
- 3 Triterpenoids of antibacterial extracts from the leaves of Bersama abyssinica Fresen (Francoaceae) 75
- 4 Physicochemical assessment and insilico studies on the interaction of 5-HT2c receptor with herbal medication bioactive compounds used in the treatment of premature ejaculation 87
- 5 Xanthoangelol, geranilated chalcone compound, isolation from pudau leaves (Artocarpus kemando Miq.) as antibacterial and anticancer 121
- 6 Exploration of bioactive compounds from Mangifera indica (Mango) as probable inhibitors of thymidylate synthase and nuclear factor kappa-B (NF-Κb) in colorectal cancer management 137
- 7 Identification of potential inhibitors of thymidylate synthase (TS) (PDB ID: 6QXH) and nuclear factor kappa-B (NF–κB) (PDB ID: 1A3Q) from Capsicum annuum (bell pepper) towards the development of new therapeutic drugs against colorectal cancer (CRC) 165
- 8 Synthesis, characterization and in vitro activity study of some organotin(IV) carboxylates against leukemia cancer cell, L-1210 199
- 9 Phytochemicals from Annona muricata (Sour Sop) as potential inhibitors of SARS-CoV-2 main protease (Mpro) and spike receptor protein: a structure-based drug design studies and chemoinformatics analyses 207
- 10 Identification of novel inhibitors of P13K/AKT pathways: an integrated in-silico study towards the development of a new therapeutic agent against ovarian cancer 231
- 11 Immobilization of α-amylase from Aspergillus fumigatus using adsorption method onto zeolite 261
- 12 Phytochemical components and GC–MS analysis of Petiveria alliaceae L. fractions and volatile oils 273
- 13 Characterization of crude saponins from stem bark extract of Parinari curatellifolia and evaluation of its antioxidant and antibacterial activities 287
- 14 Physicochemical and free radical scavenging activity of Adansonia digitata seed oil 307
- 15 Photoprotection strategies with antioxidant extracts: a new vision 321
- 16 A systematic DFT study of arsenic doped iron cluster AsFen (n = 1–4) 335
- 17 Effect of case-based learning, team-based learning and regular teaching methods on secondary school students’ self-concept in chemistry in Maara sub-county, Tharaka Nithi county, Kenya 345
- 18 Random and block architectures of N-arylitaconimide monomers with methyl methacrylate 359
- 19 Evaluation of phytochemicals and amino acid profiles of four vegetables grown on a glyphosate contaminated soil in Southwestern Nigeria 399
- Index 411
