Objectives To examine the impact of haematological and biochemical abnormalities on the failure of point-of-care troponin T (POCT) testing in patients with suspected acute coronary syndrome (ACS). Case presentation Five patients underwent Roche Troponin T Card Test (lateral flow immunoassay) in an emergency setting. Despite correct sampling and procedural adherence, no valid results were obtained resulting in an aborted test. Laboratory analysis revealed severe anaemia, polycythaemia, leucocytosis, thrombocytopenia, and hepatic and renal dysfunction across cases. After stabilization, repeat POCT yielded valid results in all survivors, correlating with normalized haematological parameters. Conclusions Pre-analytical factors such as extreme haematocrit, leucocytosis, and biochemical derangements can cause POCT failure. Pre-testing screening and guideline updates are essential to optimize POCT reliability in acute care.
Impact Factor: 2.0
Journal
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Diagnosis
Official Journal of The Community Improving Diagnosis in Medicine
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Editors-in-Chief:
Mark L. Graber
Language:
English
First published:
January 22, 2014
Publication Frequency:
4 issues per year
About this journal
Objective
Diagnosis focuses on how diagnosis can be advanced, how it is taught, and how and why it can fail, leading to diagnostic errors. The journal welcomes both fundamental and applied works, improvement initiatives, opinions, and debates to encourage new thinking on improving this critical aspect of healthcare quality.
Diagnosis is a hybrid online only journal that is published quarterly. All contributions submitted for publication in Diagnosis are subject to single-anonymized peer review by at least two experts in the field, selected and invited by the Editor-in-Chief and a dedicated Editorial Team. Diagnosis only publishes articles in English.
Diagnosis is the official journal of The Community Improving Diagnosis in Medicine (CIDM).
Topics
Factors that promote diagnostic quality and safety // Clinical reasoning // Diagnostic errors in medicine // The factors that contribute to diagnostic error: human factors, cognitive issues, and system-related breakdowns // Improving the value of diagnosis – eliminating waste and unnecessary testing // How culture and removing blame promote awareness of diagnostic errors // Training and education related to clinical reasoning and diagnostic skills // Advances in laboratory testing and imaging that improve diagnostic capability // Local, national and international initiatives to reduce diagnostic error
Article formats
Original Article // Review (systematic, narrative, and focused reviews) // Opinion Paper // Point/Counterpoint // Editorial // Short Communication (reports of early research results and pilot studies) // Letter to the Editor // Guidelines and Recommendations // Case Report – Learning from Tragedy (case reports of diagnostic error or dilemma discussed from a multi-stakeholder perspective) // Case Report – Lessons in Clinical Reasoning (Pitfalls, Myths, and Pearls) // Patient-Focused Articles (papers in this category should be written in lay language on a topic of interest to the patient stakeholder community)
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Our real journal is: DIAGNOSIS - Our real publisher: DE GRUYTER BRILL - Our real website: https://www.degruyter.com/dx - Manuscript submission page: https://mc.manuscriptcentral.com/diagnosis
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- Cutting-edge and authoritative contributions
- Academic and clinical aspects of quality and safety in healthcare combination
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Authors have the option of publishing their articles under the Creative Commons Attribution (CC-BY-4.0) open access license. Open access allows authors to retain copyright and share their findings with the scientific community without restrictions. Authors who belong to an institution that has an agreement with the publisher can publish open access without paying an article processing charge (APC) or at a considerable discount
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Issue 4
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Issue 3
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Issue 2
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Issue 1Special issue: The Future of Diagnosis; Issue Editors: Mark Graber, Ava L. Liberman, Andrew Olson, Andrew S. Parsons, Verity Schaye
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Issue 4Special Issue: COVID-19: The Diagnostic Challenge
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Issue 3Special issue: Situativity: A Family of Social Cognitive Theories for Clinical Reasoning and Error; Issue Editors: Steven Durning, Eric Holmboe, Mark L. Graber
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Issue 2
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Issue 1
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Issue 4
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Issue 3
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Issue 2Special Issue: Health Professions Education Special Issue / Issue Editors: Gurpreet Dhaliwal, Andrew Olson, Geeta Singhal
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Issue 1Special Issue: The Preanalytical Phase – A Field for Diagnostic Improvement / Issue Editor: Alexander von Meyer
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Issue 4
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Issue 3Special Issue: Improving diagnosis in radiology – progress and proposals / Guest Editors: Michael Bruno, Kevin Johnson, Nick Argy and Mark L. Graber
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Issue 2
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Issue 1
| Journal Impact Factor | 2.0 | 2024, Journal Citation Reports (Clarivate, 2025) |
| 5-year Journal Impact Factor | 2.4 | 2024, Journal Citation Reports (Clarivate, 2025) |
| Journal Citation Indicator | 0.60 | 2024, Journal Citation Reports (Clarivate, 2025) |
| CiteScore | 4.7 | 2024, Scopus (Elsevier B.V., 2025) |
| SCImago Journal Rank | 0.642 | 2024, SJR (Scimago Lab, 2025; Data Source: Scopus) |
| Source Normalized Impact per Paper | 0.866 | 2024, CWTS Journal Indicators (CWTS B.V., 2025; Data Source: Scopus) |
- You can easily submit your manuscript online. Simply go to http://mc.manuscriptcentral.com/diagnosis and you will be guided through the whole submission and publishing process.
- Prepare your manuscript according to the author guidelines and submission checklist.
- Diagnosis follows Tier 3 of our Data Sharing Policy. Authors are required to provide a data availability statement. Please refer to the Data Sharing Policy for guidance on how to write a data availability statement.
- As a condition of submission, the Template for Ethical and Legal Declarations must be customized by the submitting author on behalf of all others and uploaded as a separate Word file.
- If you have any general questions please visit our FAQ page for authors.
Co-Editors
- Mark L. Graber, Society to Improve Diagnosis in Medicine (SIDM), Plymouth, MA
- Mario Plebani, University Hospital, Padova, Italy
Associate Editors
- Christina L. Cifra, Boston Children's Hospital, MA
- Giuseppe Lippi, University Hospital of Verona, Verona, Italy
- Andrew Olson, University of Minnesota Medical School, Minneapolis, MN
- Satid Thammasitboon, Baylor College of Medicine, Texas Children's Hospital, Houston, TX
- Dario Torre, Primary Uniformed Services, University of Medicine, Bethesda, MD
Section Editors – Case Reports
- Andrew Parsons, University of Virginia, Charlottesviille, VA
- Melissa Plesac, University of Minnesota Medical Center, Minneapolis, MN
- Verity Schaye, New York University School of Medicine, New York, NY
Editorial Board
- Daniela Basso, University Hospital of Padova, Padova, Italy
- Carmel Crock, Melbourne, Royal Victorian Eye and Ear Hospital, Australia
- Pat Croskerry, Dalhousie University, Halifax, Canada
- Gurpreet Dhaliwal, San Francisco VA Medical Center, San Francisco, CA
- John Ely, University of Iowa Carver College of Medicine, Iowa City, IA
- Evangelos Giannitsis, University of Heidelberg, Heidelberg, Germany
- Michael Laposata, University of Texas Medical Branch, Galveston, TX
- Yoryos Lyratzopolous, University of Cambridge, Cambridge, United Kingdom
- Jason Maude, Isabel Healthcare, Surrey, United Kingdom
- David Newman-Toker, Johns Hopkins Hospital, Baltimore, MD
- Joseph J. Rencic, Boston University School of Medicine, Boston, MA
- Taro Shimizu, Dokkyo Medical University Graduate School of Medicine, Tochigi, Japan
- Geeta Singhal, Baylor College of Medicine, Pediatrics, Houston, TX
- Dean F. Sittig, University of Texas Health Science Center, Houston, TX
- Alexander von Meyer, Weiden, Germany
- Laura Zwaan, Institute of Medical Education Research Rotterdam (iMERR), Erasmus MC, Rotterdam, Netherlands
Editorial
Heike Jahnke
De Gruyter Brill
Berlin, Germany
E-mail: diagnosis.editorial@degruyter.com
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Topics
- Data Sharing Policy
- Online Submission of Manuscripts
- License Agreement
- Publish your article
- Publishing Ethics Policy
- Data Sharing Policy
- Open Access Policy
- Abstracting & Indexing
- Rights & Permissions
- Repository Policy
- Privacy Policy
- Sharing your Work
- The Community Improving Diagnosis in Medicine
- 2024 Reviewer Thank You
Journal information
Additional information
eISSN:
2194-802X
Language:
English
Publisher:
De Gruyter
Additional information
First published:
January 22, 2014
Publication Frequency:
4 issues per year
eISSN:
2194-802X
Audience(s) for this journal
academics, physicians, educators, healthcare managers and leaders, patients, the diagnostic industry, and policy makers
