Abstract
Over-testing, or the inappropriate use of diagnostic tests, is a highly prevalent phenomenon in modern medical practice, driven by a variety of physician, patient/disease, practice environment and system-related factors. Most of the time, physician proclivities to over-investigate fundamentally reflects a flawed clinical reasoning process under real-world practice conditions. Over the years, various educational campaigns and interventions such as the Choosing Wisely programme have been attempted to varying success, without clear evidence of a sustained reduction in the excessive/inappropriate use of diagnostic tests in clinical practice. Therefore, in this article, we hope to provide fresh perspectives on the concept of “diagnostic stewardship”, which has hitherto been largely confined to the realm of infectious diseases to govern responsible clinical use of antimicrobials, by explaining its role in the delivery of patient-centered and sustainable healthcare. We further explore the underlying contributors to over-testing and how it relates to flaws in clinical reasoning in real-world settings. Lastly, we discuss multi-level educational and practice-based interventions that may help to curb the tide of profligate diagnostic testing behaviors.
-
Research ethics: Not applicable.
-
Informed consent: Not applicable.
-
Author contributions: IKSN wrote the manuscript. IKSN and TKL conceived the study idea. ZJL, WGWG, ACKL, TKL critically reviewed and edited the manuscript.
-
Use of Large Language Models, AI and Machine Learning Tools: None declared.
-
Conflict of interest: The authors state no conflict of interest.
-
Research funding: None declared.
-
Data availability: Not applicable.
References
1. Carpenter, CR, Raja, AS, Brown, MD. Overtesting and the downstream consequences of overtreatment: implications of ‘preventing overdiagnosis’ for emergency medicine. Acad Emerg Med 2015;22:1484–92. https://doi.org/10.1111/acem.12820.Suche in Google Scholar PubMed
2. Chauvin, A, Lang, E, Bossuyt, P. When less is more: mitigating the harms and risks of over-testing through shared decision making. Canadian Journal of Emergency Medicine 2022;24:126–7. https://doi.org/10.1007/s43678-021-00231-7.Suche in Google Scholar PubMed
3. Levinson, W, Kallewaard, M, Bhatia, S, Wolfson, D, Shortt, S, Kerr, EA. ‘Choosing wisely’: a growing international campaign on behalf of the choosing wisely international working group. BMJ Qual Saf 2015;24:167–74. https://doi.org/10.1136/bmjqs-2014-003821.Suche in Google Scholar PubMed
4. Lenzer, J. Choosing wisely: setbacks and progress. BMJ 2015;351:h6760. https://doi.org/10.1136/bmj.h6760.Suche in Google Scholar PubMed
5. Davis, DS. Hurdles of trying to avoid low-value care: two cheers for choosing wisely. BMJ Evidence-Based Medicine 2024;30:138–139. https://doi.org/10.1136/bmjebm-2024-113283.Suche in Google Scholar PubMed
6. Colla, CH, Mainor, AJ. Choosing wisely campaign: valuable for providers who knew about it, but awareness remained constant, 2014-17. Health Aff 2017;36:2005–11. https://doi.org/10.1377/hlthaff.2017.0945.Suche in Google Scholar PubMed
7. Rosenberg, A, Agiro, A, Gottlieb, M, Barron, J, Brady, P, Liu, Y, et al.. Early trends among seven recommendations from the choosing wisely campaign. JAMA Intern Med 2015;175:1913–20. https://doi.org/10.1001/jamainternmed.2015.5441.Suche in Google Scholar PubMed
8. Baron, RJ, Lynch, TJ, Rand, K. Lessons from the choosing wisely campaign’s 10 years of addressing overuse in health care. JAMA Health Forum 2022;3:e221629. https://doi.org/10.1001/jamahealthforum.2022.1629.Suche in Google Scholar PubMed
9. Centers for Disease Control and Prevention [Internet]. Core elements of hospital diagnostic excellence (DxEx). 2025. Available from: https://www.cdc.gov/patient-safety/hcp/hospital-dx-excellence/index.html Suche in Google Scholar
10. Etymonline [Internet]. Origin and history of stewardship. 2025. Available from: https://www.etymonline.com/word/stewardship Suche in Google Scholar
11. Schpero, WL, Morden, NE, Sequist, TD, Rosenthal, MB, Gottlieb, DJ, Colla, CH. For selected services, blacks and hispanics more likely to receive low-value care than whites. Health Aff 2017;36:1065–9. https://doi.org/10.1377/hlthaff.2016.1416.Suche in Google Scholar PubMed PubMed Central
12. Beauchamp, T, Childress, J. Principles of biomedical ethics. Oxford: Oxford University Press; 1979.Suche in Google Scholar
13. Shaik, T, Mahmood, R, Kanagala, SG, Kaur, H, Mendpara, V, Gupta, V, et al.. Lab testing overload: a comprehensive analysis of overutilization in hospital-based settings. Baylor Univ Med Center Proc 2024;37:312–6. https://doi.org/10.1080/08998280.2023.2288788.Suche in Google Scholar PubMed PubMed Central
14. Greenberg, J, Green, JB. Over-testing: why more is not better. Am J Med 2014;127:362–3. https://doi.org/10.1016/j.amjmed.2013.10.024.Suche in Google Scholar PubMed
15. Fabre, V, Davis, A, Diekema, DJ, Granwehr, B, Hayden, MK, Lowe, CF, et al.. Principles of diagnostic stewardship: a practical guide from the society for healthcare epidemiology of America diagnostic stewardship task force. Infect Control Hosp Epidemiol 2023;44:178–85. https://doi.org/10.1017/ice.2023.5.Suche in Google Scholar PubMed
16. Lumbreras, B, Donat, L, Hernández-Aguado, I. Incidental findings in imaging diagnostic tests: a systematic review. Br J Radiol 2010;83:276–89.10.1259/bjr/98067945Suche in Google Scholar PubMed PubMed Central
17. Claeys, KC, Coffey, KC, Morgan, DJ. What is diagnostic stewardship? J Appl Lab Med 2025;10:130–9. https://doi.org/10.1093/jalm/jfae130.Suche in Google Scholar PubMed
18. Singh, HK, Claeys, KC, Advani, SD, Ballam, YJ, Penney, J, Schutte, KM, et al.. Diagnostic stewardship to improve patient outcomes and healthcare-associated infection (HAI) metrics. Infect Control Hosp Epidemiol 2024;45:405–11. https://doi.org/10.1017/ice.2023.284.Suche in Google Scholar PubMed PubMed Central
19. Dickerson, JA, Fletcher, AH, Procop, G, Keren, DF, Singh, IR, Garcia, JJ, et al.. Transforming laboratory utilization review into laboratory stewardship: Guidelines by the plugs national committee for laboratory stewardship. Journal of Applied Laboratory Medicine 2017;2:259–68. https://doi.org/10.1373/jalm.2017.023606.Suche in Google Scholar PubMed
20. Woods-Hill, CZ, Colantuoni, EA, Koontz, DW, Voskertchian, A, Xie, A, Thurm, C, et al.. Association of diagnostic stewardship for blood cultures in critically ill children with culture rates, antibiotic use, and patient outcomes: results of the Bright STAR collaborative. JAMA Pediatr 2022;176:690–8. https://doi.org/10.1001/jamapediatrics.2022.1024.Suche in Google Scholar PubMed PubMed Central
21. Silvari, V, Crowley, EK, Carey, M, Robertson, S, McCarthy, S. Value of hospital anticoagulation stewardship programme: a systematic review. Thrombosis Update 2024;14:100158. https://doi.org/10.1016/j.tru.2023.100158.Suche in Google Scholar
22. Moleman, M, Zuiderent-Jerak, T, Lageweg, M, van den Braak, GL, Schuitmaker-Warnaar, TJ. Doctors as resource stewards? Translating high-value, cost-conscious care to the consulting room. Health Care Anal 2022;30:215–39. https://doi.org/10.1007/s10728-022-00446-4.Suche in Google Scholar PubMed PubMed Central
23. Müskens, JLJM, Kool, RB, van Dulmen, SA, Westert, GP. Overuse of diagnostic testing in healthcare: a systematic review. BMJ Qual Saf 2022;31:54–63. https://doi.org/10.1136/bmjqs-2020-012576.Suche in Google Scholar PubMed PubMed Central
24. Kanzaria, HK, Hoffman, JR, Probst, MA, Caloyeras, JP, Berry, SH, Brook, RH. Emergency physician perceptions of medically unnecessary advanced diagnostic imaging. Acad Emerg Med; 2015;22:390–810.1111/acem.12625Suche in Google Scholar PubMed
25. Bai, L, Gao, S, Burstein, F, Kerr, D, Buntine, P, Law, N. A systematic literature review on unnecessary diagnostic testing: the role of ICT use. Int J Med Inform 2020;143:104269. https://doi.org/10.1016/j.ijmedinf.2020.104269.Suche in Google Scholar PubMed
26. Kern-Goldberger, AS, Dalton, EM, Rasooly, IR, Congdon, M, Gunturi, D, Wu, L, et al.. Factors associated with inpatient subspecialty consultation patterns among pediatric hospitalists. JAMA Netw Open 2023;6: e232648. https://doi.org/10.1001/jamanetworkopen.2023.2648.Suche in Google Scholar PubMed PubMed Central
27. Lam, JH, Pickles, K, Stanaway, FF, Bell, KJL. Why clinicians overtest: development of a thematic framework. BMC Health Serv Res 2020;20:1011. https://doi.org/10.1186/s12913-020-05844-9.Suche in Google Scholar PubMed PubMed Central
28. Kinnear, B, Hagedorn, PA, Kelleher, M, Ohlinger, C, Tolentino, J. Integrating Bayesian reasoning into medical education using smartphone apps. Diagnosis 2019;6:85–9. https://doi.org/10.1515/dx-2018-0065.Suche in Google Scholar PubMed
29. Committee on Diagnostic Error in Health Care, Board on Health Care Services, Balogh, E, Miller, B, Ball, J, editors. Improving diagnosis in health care. Washington: Institute of medicine, the national academies of sciences E and M., National Academies Press; 2015.Suche in Google Scholar
30. Croskerry, P. Achieving quality in clinical decision making: cognitive strategies and detection of bias. Acad Emerg Med 2002;9:1184–204. https://doi.org/10.1197/aemj.9.11.1184.Suche in Google Scholar
31. Ries, NM, Jansen, J. Physicians’ views and experiences of defensive medicine: an international review of empirical research. Health Policy 2021;125:634–42. https://doi.org/10.1016/j.healthpol.2021.02.005.Suche in Google Scholar PubMed
32. Ng, IKS, Goh, WGW, Teo, DB, Chong, KM, Tan, LF, Teoh, CM. Clinical reasoning in real-world practice: a primer for medical trainees and practitioners. Postgrad Med J 2024;101:68–75. https://doi.org/10.1093/postmj/qgae079.Suche in Google Scholar PubMed
33. Moorhouse, A. Decision fatigue: less is more when making choices with patients. Br J Gen Pract 2020;70:399. https://doi.org/10.3399/bjgp20x711989.Suche in Google Scholar
34. Moynihan, R, Doust, J, Henry, D. Preventing overdiagnosis: how to stop harming the healthy. BMJ 2012;344:e3502. https://doi.org/10.1136/bmj.e3502.Suche in Google Scholar PubMed
35. Neuman, J, Korenstein, D, Ross, JS, Keyhani, S. Prevalence of financial conflicts of interest among panel members producing clinical practice guidelines in Canada and United States: cross sectional study. BMJ 2011;343:d5621. https://doi.org/10.1136/bmj.d5621.Suche in Google Scholar PubMed PubMed Central
36. Ng, IK, Morgan, DJ, Tow Keang, L. Why do doctors make poor decisions? Spotlighting ‘noise’ as an under-recognised source of error in clinical practice. J R Soc Med 2025;118:1410768251324822.10.1177/01410768251324822Suche in Google Scholar PubMed PubMed Central
37. de Alencastro, L, Locatelli, I, Clair, C, Ebell, MH, Senn, N. Correlation of clinical decision-making with probability of disease: a web-based study among general practitioners. PLoS One 2020;15:e0241210. https://doi.org/10.1371/journal.pone.0241210.Suche in Google Scholar PubMed PubMed Central
38. Morgan, DJ, Pineles, L, Owczarzak, J, Magder, L, Scherer, L, Brown, JP, et al.. Accuracy of practitioner estimates of probability of diagnosis before and after testing. JAMA Intern Med 2021;181:747–55. https://doi.org/10.1001/jamainternmed.2021.0269.Suche in Google Scholar PubMed PubMed Central
39. Szulewski, A, Howes, D, Van Merriënboer, JJG, Sweller, J. From theory to practice: the application of cognitive load theory to the practice of medicine. Acad Med 2021;96:24–30. https://doi.org/10.1097/acm.0000000000003524.Suche in Google Scholar
40. Ng, I, Goh, W, Lim, T. Beyond thinking fast and slow: a bayesian intuitionist model of clinical reasoning in real-world practice. Diagnosis 2024;12:182–188. https://doi.org/10.1515/dx-2024-0169.Suche in Google Scholar PubMed
41. Armstrong, KA, Metlay, JP. Annals clinical decision making: using a diagnostic Test. Ann Intern Med 2020;172:604–9. https://doi.org/10.7326/m19-1940.Suche in Google Scholar PubMed
42. Scott, IA, Doust, JA, Keijzers, GB, Wallis, KA. Coping with uncertainty in clinical practice: a narrative review. Med J Aust 2023;218:418–25. https://doi.org/10.5694/mja2.51925.Suche in Google Scholar PubMed
43. Papanagnou, D, Klein, MR, Zhang, XC, Cameron, KA, Doty, A, McCarthy, DM, et al.. Developing standardized patient-based cases for communication training: lessons learned from training residents to communicate diagnostic uncertainty. Advances in Simulation 2021;6:26. https://doi.org/10.1186/s41077-021-00176-y.Suche in Google Scholar PubMed PubMed Central
44. Siedlikowski, S, Ells, C, Bartlett, G. Scrutinizing screening: a critical interpretive review of primary care provider perspectives on mammography decisionmaking with average-risk women. Public Health Rev. 2018; 39:15. https://doi.org/10.1186/s40985-018-0092-9.Suche in Google Scholar PubMed PubMed Central
45. Messacar, K, Parker, SK, Todd, JK, Dominguez, SR. Implementation of rapid molecular infectious disease diagnostics: the role of diagnostic and antimicrobial stewardship. J Clin Microbiol 2017;55:715–23. https://doi.org/10.1128/jcm.02264-16.Suche in Google Scholar PubMed PubMed Central
46. Morgan, D. Testing wisely. 2025. Available from: https://www.testingwisely.com/.Suche in Google Scholar
47. Gillespie, CS, Hanrahan, JG, Mahdiyar, R, Lee, KS, Ashraf, M, Alam, AM, et al.. Diagnosis of subarachnoid haemorrhage: systematic evaluation of CT head diagnostic accuracy and comparison with the 2022 NICE guidelines. Brain and Spine 2025;5:104200. https://doi.org/10.1016/j.bas.2025.104200.Suche in Google Scholar PubMed PubMed Central
48. Rozenfeld, MN, Ansari, SA, Shaibani, A, Russell, EJ, Mohan, P, Hurley, MC. Should patients with autosomal dominant polycystic kidney disease be screened for cerebral aneurysms? Am J Neuroradiol 2014;35:3–9. https://doi.org/10.3174/ajnr.a3437.Suche in Google Scholar
49. Cox, AT, Cox, AT, Cameron-Smith, M, Folkes, F, Boos, C. Screening for cardiac disease in potential recruits to the British Army. J R Army Med Corps 2015;161:173–9. https://doi.org/10.1136/jramc-2015-000532.Suche in Google Scholar PubMed
50. Boyer, O, Bernardi, S, Preka, E. To biopsy or not to biopsy a teenager with typical idiopathic nephrotic syndrome? Start steroids first. Pediatr Nephrol 2024;40:579–85. https://doi.org/10.1007/s00467-024-06447-w.Suche in Google Scholar PubMed
51. Morjaria, S, Chapin, KC. Who to Test, when, and for what: why diagnostic stewardship in infectious diseases matters. J Mol Diagn 2020;22:1109–13. https://doi.org/10.1016/j.jmoldx.2020.06.012.Elsevier B.V.Suche in Google Scholar PubMed
52. Grouse, CK, Waung, MW, Holmgren, AJ, Mongan, J, Neinstein, A, Josephson, SA, et al.. Behavioral ‘nudges’ in the electronic health record to reduce waste and misuse: 3 interventions. J Am Med Inf Assoc 2023;30:545–50. https://doi.org/10.1093/jamia/ocac238.Suche in Google Scholar PubMed PubMed Central
53. Raban, MZ, Gonzalez, G, Nguyen, AD, Newell, BR, Li, L, Seaman, KL, et al.. Nudge interventions to reduce unnecessary antibiotic prescribing in primary care: a systematic review. BMJ Open 2023;13:e062688. https://doi.org/10.1136/bmjopen-2022-062688.Suche in Google Scholar PubMed PubMed Central
54. Yale, S, Cohen, S, Bordini, B. Diagnostic time-outs to improve diagnosis. Crit Care Clin 2022;38:185–94. https://doi.org/10.1016/j.ccc.2021.11.008.Suche in Google Scholar PubMed
55. Lim, T, Teoh, C. Exploiting predictive brains for better diagnosis. Diagnosis. 2018;5:eA40.Suche in Google Scholar
56. Yong, SEF, Wong, ML, Voo, TC. Screening is not always healthy: an ethical analysis of health screening packages in Singapore. BMC Med Ethics 2022;23:57. https://doi.org/10.1186/s12910-022-00798-5.Suche in Google Scholar PubMed PubMed Central
© 2025 Walter de Gruyter GmbH, Berlin/Boston