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Kapitel in diesem Buch
- Frontmatter i
- Contents ix
- List of Illustrations xi
- Preface xiii
- Acknowledgments xv
- Abbreviations xvii
-
Part One. The Vanishing Cures
- 1. The Drug Discovery Crisis 3
- 2. A New Science of Molecules 24
- 3. The Birth of the First Cancer Drugs 45
- 4. A New Company Creating Drug Combinations 66
- 5. The Undruggable RAS Protein 81
- 6.The Druggable Genome 101
-
Part Two. The Path to the Next Generation of Medicines
- 7. Peering Inside Proteins 119
- 8. The Nature of Interactions Between Proteins 139
- 9. From Protein- Protein Interactions to Personalized Medicines 156
- 10. A Revolution in Peptide Synthesis 169
- 11. A Vast Array of Drug Candidates 185
- 12. Moving Outside the Small Molecule Box 205
- 13. Accelerating the Arrival of Next- Generation Drugs 224
- Notes 229
- Glossary 251
- Index 255
Kapitel in diesem Buch
- Frontmatter i
- Contents ix
- List of Illustrations xi
- Preface xiii
- Acknowledgments xv
- Abbreviations xvii
-
Part One. The Vanishing Cures
- 1. The Drug Discovery Crisis 3
- 2. A New Science of Molecules 24
- 3. The Birth of the First Cancer Drugs 45
- 4. A New Company Creating Drug Combinations 66
- 5. The Undruggable RAS Protein 81
- 6.The Druggable Genome 101
-
Part Two. The Path to the Next Generation of Medicines
- 7. Peering Inside Proteins 119
- 8. The Nature of Interactions Between Proteins 139
- 9. From Protein- Protein Interactions to Personalized Medicines 156
- 10. A Revolution in Peptide Synthesis 169
- 11. A Vast Array of Drug Candidates 185
- 12. Moving Outside the Small Molecule Box 205
- 13. Accelerating the Arrival of Next- Generation Drugs 224
- Notes 229
- Glossary 251
- Index 255