Contents

Chapters in this book

1. Frontmatter i
2. Contents ix
3. List of Illustrations xi
4. Preface xiii
5. Acknowledgments xv
6. Abbreviations xvii
7. Part One. The Vanishing Cures
8. 1. The Drug Discovery Crisis 3
9. 2. A New Science of Molecules 24
10. 3. The Birth of the First Cancer Drugs 45
11. 4. A New Company Creating Drug Combinations 66
12. 5. The Undruggable RAS Protein 81
13. 6.The Druggable Genome 101
14. Part Two. The Path to the Next Generation of Medicines
15. 7. Peering Inside Proteins 119
16. 8. The Nature of Interactions Between Proteins 139
17. 9. From Protein- Protein Interactions to Personalized Medicines 156
18. 10. A Revolution in Peptide Synthesis 169
19. 11. A Vast Array of Drug Candidates 185
20. 12. Moving Outside the Small Molecule Box 205
21. 13. Accelerating the Arrival of Next- Generation Drugs 224
22. Notes 229
23. Glossary 251
24. Index 255