Cytotoxic Saponins from the Seeds of Pittosporum angustifolium
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Christian Bäcker
,
Kristina Jenett-Siems
Three new acylated R1-barrigenol triterpene glycosides, 1 - 3, were isolated from the seeds of Pittosporum angustifolium Lodd. together with four known glycosides, 4 - 7, containing R1- and A1-barrigenol backbones. On the basis of spectroscopic, spectrometric, and chemical analyses the novel compounds were named pittangretosides N- P and established as 21ß-acetoxy- 22α-angeloyloxy- (1), 21ß-acetoxy-22α-(2-acetoxy-2-methylbutyroyloxy)- (2), and 21ß-(2-methylbutyroyloxy)- 22α-acetoxy-3ß-[b-D-glucopyranosyl- (1→2)]-[α-L-arabinopyranosyl-(1→3)]-[α- L-arabinofuranosyl-(1!4)]-ß-D-glucuronopyranosyloxyolean-12-ene-15α,16α,28-triol (3). Evaluation of the in vitro cytotoxicity against three tumour cell lines and one non-tumourigenic cell line revealed antiproliferative effects with IC50 values in a range of 1:74 - 34:1 μM
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- New Nitrogenous Compounds from Anisotes trisulcus
- Inhibitory Effect of the Methanolic Extract of Verbascum latisepalum Hub.-Mor. on Endothelium-Dependent Relaxation in Rat Thoracic Aorta
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Articles in the same Issue
- Chemical Constituents of Croton oligandrum (Euphorbiaceae)
- Acacetin-7-rutinoside from Buddleja lindleyana, a New Molluscicidal Agent against Oncomelania hupensis
- Cytotoxic Saponins from the Seeds of Pittosporum angustifolium
- Flavone Composition and Antihypercholesterolemic and Antihyperglycemic Activities of Chrysanthemum coronarium L.
- New Nitrogenous Compounds from Anisotes trisulcus
- Inhibitory Effect of the Methanolic Extract of Verbascum latisepalum Hub.-Mor. on Endothelium-Dependent Relaxation in Rat Thoracic Aorta
- Exogenous Ascorbic Acid and Glutathione Alleviate Oxidative Stress Induced by Salt Stress in the Chloroplasts of Oryza sativa L.
- Improved ß-Carotene and Lycopene Production by Blakeslea trispora with Ultrasonic Treatment in Submerged Fermentation
- Microbial Metabolism of Danazol: A Contribution to Doping Analysis
- Identification of Two Chemotypes of Pogostemon cablin (Blanco) Benth. through DNA Barcodes
- cDNA Cloning and Expression Analysis of Farnesyl Pyrophosphate Synthase from Ornithogalum saundersiae
