New Nitrogenous Compounds from Anisotes trisulcus
-
Mohamed A. El-Shanawany
and
Marwa A. A. Fayed
Re-investigation of the methanolic extract of Anisotes trisulcus (Forssk.) Nees aerial parts led to the isolation of two new tricyclic quinazoline alkaloids, 8-amino-7,8,9,11-tetrahydro-6H-pyrido[2,1-b]- quinazoline-2,6-diol (4) and 8-amino-3,6-dihydroxy-7,8,9-trihydro-6H-pyrido[2,1-b]quinazoline- 11-one (5), and two quaternary ammonium compounds, (dimethylamino)-N-(hydroxymethyl)-N,Ndimethyl methanaminium chloride (6) and N-[(carboxyamino)methyl]-N,N-dimethyl ethanaminium chloride (7), together with three known compounds, peganine (1), vasicinone (2), and anisotine (3). The structures of these compounds were established on the basis of physical, chemical, and spectral data (UV, IR, MS, 1D and 2D NMR), as well as by comparison with authentic samples. GC-MS analysis of the fatty acid methyl esters and unsaponifiable matter revealed the presence of 46 fatty acids, 53 hydrocarbons, and 18 sterols. The different extracts were evaluated for their antihyperglycaemic activities. The MeOH, n-hexane, and EtOAc extracts exhibited a significant hypoglycaemic effect
© 1946 – 2014: Verlag der Zeitschrift für Naturforschung
Articles in the same Issue
- Chemical Constituents of Croton oligandrum (Euphorbiaceae)
- Acacetin-7-rutinoside from Buddleja lindleyana, a New Molluscicidal Agent against Oncomelania hupensis
- Cytotoxic Saponins from the Seeds of Pittosporum angustifolium
- Flavone Composition and Antihypercholesterolemic and Antihyperglycemic Activities of Chrysanthemum coronarium L.
- New Nitrogenous Compounds from Anisotes trisulcus
- Inhibitory Effect of the Methanolic Extract of Verbascum latisepalum Hub.-Mor. on Endothelium-Dependent Relaxation in Rat Thoracic Aorta
- Exogenous Ascorbic Acid and Glutathione Alleviate Oxidative Stress Induced by Salt Stress in the Chloroplasts of Oryza sativa L.
- Improved ß-Carotene and Lycopene Production by Blakeslea trispora with Ultrasonic Treatment in Submerged Fermentation
- Microbial Metabolism of Danazol: A Contribution to Doping Analysis
- Identification of Two Chemotypes of Pogostemon cablin (Blanco) Benth. through DNA Barcodes
- cDNA Cloning and Expression Analysis of Farnesyl Pyrophosphate Synthase from Ornithogalum saundersiae
Articles in the same Issue
- Chemical Constituents of Croton oligandrum (Euphorbiaceae)
- Acacetin-7-rutinoside from Buddleja lindleyana, a New Molluscicidal Agent against Oncomelania hupensis
- Cytotoxic Saponins from the Seeds of Pittosporum angustifolium
- Flavone Composition and Antihypercholesterolemic and Antihyperglycemic Activities of Chrysanthemum coronarium L.
- New Nitrogenous Compounds from Anisotes trisulcus
- Inhibitory Effect of the Methanolic Extract of Verbascum latisepalum Hub.-Mor. on Endothelium-Dependent Relaxation in Rat Thoracic Aorta
- Exogenous Ascorbic Acid and Glutathione Alleviate Oxidative Stress Induced by Salt Stress in the Chloroplasts of Oryza sativa L.
- Improved ß-Carotene and Lycopene Production by Blakeslea trispora with Ultrasonic Treatment in Submerged Fermentation
- Microbial Metabolism of Danazol: A Contribution to Doping Analysis
- Identification of Two Chemotypes of Pogostemon cablin (Blanco) Benth. through DNA Barcodes
- cDNA Cloning and Expression Analysis of Farnesyl Pyrophosphate Synthase from Ornithogalum saundersiae
