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Synthesis and Antitumor Activity of Some N2-(Thien-3-yl)amidrazones
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Mohammed M. Abadleh
,
Mustafa M. El-Abadelah
Published/Copyright:
June 2, 2014
6a
A set of new N2-(thien-3-yl)amidrazones (-h) incorporating N-piperazines and related congeners has been synthesized by reacting the hydrazonoyl chloride 4(derived from 3-aminothiophene- 2-carboxylate) with the appropriate sec-cyclic amine. The antitumor activity of these compounds was evaluated on breast cancer (MCF-7) and leukemic (K562) cell lines by a cell viability assay utilizing the tetrazolium dye (MTT). The amidrazone 6d encompassing the N-piperazine moiety, was the most active against MCF-7 and K562 with IC50 of 7.28 and 9:91 μM, respectively.
Graphical Abstract
Synthesis and Antitumor Activity of Some N2-(Thien-3-yl)amidrazones
Keywords: 3-Aminothiophene-2-carboxylic Ester; N2-(Thien-3-yl)nitrile Imine; Piperazines; N2-(Thien-3-yl)amidrazones; Antitumor Activity
Received: 2014-3-12
Published Online: 2014-6-2
Published in Print: 2014-7-1
© 1946 – 2014: Verlag der Zeitschrift für Naturforschung
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Keywords for this article
3-Aminothiophene-2-carboxylic Ester;
N2-(Thien-3-yl)nitrile Imine;
Piperazines;
N2-(Thien-3-yl)amidrazones;
Antitumor Activity
Articles in the same Issue
- Synthesis, Structure and Thermal Decomposition of a New Iodine Inclusion Compound in the 2,2-Dimethylpropane-1,3-diamine/HI/I2 System
- Rapid Microwave Synthesis and Structural Phase Diagram of LnxY1−xMnO3
- Gold-Tin Ordering in SrAu2Sn2
- The Stannides EuPd2Sn2, EuPt2Sn2, EuAu2Sn2, and Eu5.4Sn5.6 – Structure and Magnetic Properties
- Line-Shape Analyses of Solid-state 17O NMR Spectra for Hexagonal Ice
- A Novel Alkali-Metal Hydrido-tris(pyrazolyl)borate (Tp*) Complex. Isolation and Crystal Structure of [(Me2CO)3(NaTp*)2]
- Synthesis and Structure of an Aluminum Bis(3-chloropentanedionate) Isopropoxide: [Al(μ-OiPr)(3-Clacac)2]2
- Carbon-modified MgH2: Experimental and ab-initio Investigations
- Synthesis and Antitumor Activity of Some N2-(Thien-3-yl)amidrazones
- Synthesis of New TGX-221 Analogs
- Crystal Structure Explains Crystal Habit for the Antiviral Drug Rimantadine Hydrochloride
- The Reaction of Cyanamidium Salts with Ylidenecyanamide Derivatives
- Iridoid Glycosides from Lagotis alutacea
- Solid-state and Calculated Electronic Structure of 4-Acetylpyrazole
