The Porous Structure and Mechanical Properties of Injection Molded HA/PA66 Scaffolds
-
S. Zhou
, Y.-B. Li , Y.-Y. Wang , Y. Zuo , S.-B. Gao , M. Li and L. Zhang
Abstract
Hydroxyapatite/polyamide-66 (HA/PA66) composite scaffolds were prepared using injection-molding technique, and also analyzed by means of scanning electron microscopy (SEM), dynamic mechanical analysis (DMA), Fourier transform infrared spectroscopy (FTIR) and mechanical testing. Compared with common methods including solvent casting/particulate leaching, phase separation and so forth to fabricate scaffolds, this process is of a rapid and convenient manner. The increase of HA content can increase the stiffness of composite scaffolds accompanied by the reduction of impact strength, pore size and porosity. The storage modulus of composite scaffolds increases with increasing HA content and with decreasing porosity. The damping (tan δ) of PA66 decreases with the increase of HA content, and the α and β relaxation peaks of PA66 for the foamed HA/PA66 composites slightly shift to lower value, indicating that both HA and gas in the foamed HA/PA66 composites have an effect on the chain mobility of the polymer and the interaction between the polymer chains. The microstructure of the 30 wt% and 40 wt% HA/PA66 composite scaffolds with porosity more than 59 % and pore size ranging from 100 to 500 μm is similar to that of dry human trabecular bone. The obtained composite scaffolds with 30 wt% and 40 wt% HA have a compressive modulus of 232 to 443 MPa, and a compressive strength of 9.3 to 9.8 MPa, similar to or a little higher than those of trabecular bone, and close to those of the cancellous bone.
References
Bledzki, A. K., Faruk, O., “Effects of the Chemical Foaming Agents, Injection Parameters, and Melt-Flow Index on the Microstructure and Mechanical Properties of Microcellular Injection-Molded Wood-Fiber/Polypropylene Composites”, J. Appl. Polym. Sci., 97, 1090–1096 (2005) 10.1002/app.21685Search in Google Scholar
Boyana, B. D., Hummert, B. D., Dean, D. D. and Schwartz, Z., “Role of Material Surfaces in Regulating Bone and Cartilage Cell Response”, Biomaterials, 17, 137–146 (1996) 10.1016/0142-9612(96)85758-9Search in Google Scholar PubMed
Chandra, A., Gong, S. Q., Yuan, M. J. and Turng, L. S., “Microstructure and Crystallography in Microcellular Injection-Molded Polyamide-6 Nanocomposite and Neat Resin”, Polym. Eng. Sci., 45, 52–61 (2005) 10.1002/pen.20229Search in Google Scholar
Charriere, E., Lemaitre, J. and Zysset, P., “Hydroxyapatite Cement Scaffolds with Controlled Macroporosity: Fabrication Protocol and Mechanical Properties”, Biomaterials., 24, 809–817 (2003) 10.1016/S0142-9612(02)00406-4Search in Google Scholar
Chow, W. S., Bakar, A. A., Ishak, Z. A. M., Kocsis, J. K. and Ishiaku, U. S., “Effect of Maleic Anhydride-Grafted Ethylene-Propylene Rubber on the Mechanical, Rheological and Morphological Properties of Organoclay Reinforced Polyamide 6/Polypropylene Nanocomposites”, Eur. Polym. J., 41, 687–696 (2005) 10.1016/j.eurpolymj.2004.10.041Search in Google Scholar
Fu, Q., Rahaman, M. N., Bal, B. S., Brown, R. F. and Day, D. E., “Mechanical and in Vitro Performance of 13–93 Bioactive Glass Scaffolds Prepared by a Polymer Foam Replication Technique”, Acta Biomater., 4, 1854–1864 (2008) 10.1016/j.actbio.2008.04.019Search in Google Scholar PubMed
Ghosh, S., Gutierrez, V., Fernandez, C., Perez, M. A. R., Viana, J. C., Reis, R. L. and Mano, J. F., “Dynamic Mechanical Behavior of Starch-Based Scaffolds in Dry and Physiologically Simulated Conditions: Effect of Porosity and Pore Size”, Acta Biomaterialia., 4, 950–959 (2008) 10.1016/j.actbio.2008.02.001Search in Google Scholar PubMed
Gibson, L. J., “Biomechanics of Cellular Solids”, J. Biomech., 38, 377–399 (2005) 10.1016/j.jbiomech.2004.09.027Search in Google Scholar PubMed
Gomes, M. E., Ribeiro, A. S., Malafaya, P. B., Reis, R. L. and Cunha, A. M., “A New Approach Based on Injection Moulding to Produce Biodegradable Starch-Based Polymeric Scaffolds: Morphology, Mechanical and Degradation Behaviour”, Biomaterials, 22, 883–889 (2001) 10.1016/S0142-9612(00)00211-8Search in Google Scholar PubMed
Guo, M. C., Heuzey, M. C. and Carreau, P. J., “Cell Structure and Dynamic Properties of Injection Molded Polypropylene Foams”, Polym. Eng. Sci., 47, 1070–1081 (2007) 10.1002/pen.20786Search in Google Scholar
Hedberg, E. L., Shih, C. K., Lemoine, J. J., Timmer, M. D., Liebschner, M. A., Jansen, J. A. and Mikos, A. G., “In Vitro Degradation of Porous Poly(propylene fumarate)/Poly(DL-lactic-co-glycolic acid) Composite Scaffolds”, Biomaterials, 26, 3215–3225 (2005) 10.1016/j.biomaterials.2004.09.012Search in Google Scholar PubMed
Hou, Q. P., Grijpma, D. W. and Feijen, J., “Porous Polymeric Structures for Tissue Engineering Prepared by a Coagulation, Compression Moulding and Salt Leaching Technique”, Biomaterial., 24, 1937–1947 (2003) 10.1016/S0142-9612(02)00562-8Search in Google Scholar
Jansen, E. J. P., Sladek, R. E. J., Bahar, H., Yaffe, A., Gijbels, M. J., Kuijer, R., Bulstra, S. K., Guldemond, N. A., Binderman, I. and Koole, L. H., “Hydrophobicity as a Design Criterion for Polymer Scaffolds in Bone Tissue Engineering”, Biomaterials, 26, 4423–4431 (2005) 10.1016/j.biomaterials.2004.11.011Search in Google Scholar PubMed
Karageorgiou, V., Kaplan, D., “Porosity of 3D Biomaterial Scaffolds and Osteogenesis”, Biomaterials, 26, 5474–5491 (2005) 10.1016/j.biomaterials.2005.02.002Search in Google Scholar PubMed
Kothapalli, C. R., Shaw, M. T. and Wei, M., “Biodegradable HA-PLA 3-D Porous Scaffolds: Effect of Nano-Sized Filler Content on Scaffold Properties”, Acta Biomater., 1, 653–662 (2005) 10.1016/j.actbio.2005.06.005Search in Google Scholar PubMed
Lin, A. S. P., Barrows, T. H., Cartmell, S. H. and Guldberg, R. E., “Microarchitectural and Mechanical Characterization of Oriented Porous Polymer Scaffolds”, Biomaterials, 24, 481–489 (2003) 10.1016/S0142-9612(02)00361-7Search in Google Scholar PubMed
Lu, H. H., El-Amin, S. F., Scott, K. D. and Laurencin, C. T., “Three-dimensional, Bioactive, Biodegradable, Polymer-Bioactive Glass Composite Scaffolds with Improved Mechanical Properties Support Collagen Synthesis and Mineralization of Human Osteoblast-like Cells in Vitro”, J. Biomed. Mater. Res A., 64A, 465–474 (2003) 10.1002/jbm.a.10399Search in Google Scholar PubMed
Maquet, V., Boccaccini, A. R., Pravata, L., Notingher, I. and Jerome, R., “Porous Poly(α-hadroxyacid)/Bioglass Composite Scaffolds for Bone Tissue Engineering: Preparation and in Vitro Characterization”, Biomaterials, 25, 4185–4194 (2004) 10.1016/j.biomaterials.2003.10.082Search in Google Scholar PubMed
Park, S. N., Park, J. C., Kim, H. O., Song, M. J. and Suh, H., “Characterization of Porous Collagen/Hyaluronic Acid Scaffold Modified by 1-ethyl-3-(3-dimethylaminopropyl) Carbodiimide Cross-Linking”, Biomaterials, 23, 1205–1212 (2002) 10.1016/S0142-9612(01)00235-6Search in Google Scholar PubMed
Ramay, H. R., Zhang, M., “Preparation of Porous Hydroxyapatite Scaffolds by Combination of the Gel-casting and Polymer Sponge Methods”, Biomaterials, 24, 3293–3302 (2003) 10.1016/S0142-9612(03)00171-6Search in Google Scholar PubMed
Rezwan, K., Chen, Q. Z., Blaker, J. J. and Boccaccini, A. R., “Biodegradable and Bioactive Porous Polymer/Inorganic Composite Scaffolds for Bone Tissue Engineering”, Biomaterials, 27, 3413–3431 (2006) 10.1016/j.biomaterials.2006.01.039Search in Google Scholar PubMed
Springer, I. N., Fleiner, B., Jepsen, S. and Açil, Y., “Culture of Cells Gained From Temporomandibular Joint Cartilage on Non-Absorbable Scaffolds”, Biomaterials. 22, 2569–2577 (2001) 10.1016/S0142-9612(01)00148-XSearch in Google Scholar
Wang, H. N., Li, Y. B., Zuo, Y., Li, J. H., Ma, S. S. and Cheng, L., “Biocompatibility and Osteogenesis of Biomimetic Nano-Hydroxyapatite/Polyamide Composite Scaffolds for Bone Tissue Engineering”, Biomaterials, 28, 3338–3348 (2007) 10.1016/j.biomaterials.2007.04.014Search in Google Scholar PubMed
Wei, G. B., Ma, P. X., “Structure and Properties of Nano-Hydroxyapatite/Polymer Composite Scaffolds for Bone Tissue Engineering”, Biomaterials, 25, 4749–4757 (2004) 10.1016/j.biomaterials.2003.12.005Search in Google Scholar PubMed
Wei, J., Li, Y. B., “Tissue Engineering Scaffold Material of Nanoapatite Crystals and Polyamide Composite”, Eur. Polym. J., 40, 509–515 (2004) 10.1016/j.eurpolymj.2003.10.028Search in Google Scholar
Wei, J., Li, Y. B. and Lau, K. T., “Preparation and Characterization of a Nanoapatite/Polyamide 6 Bioactive Composite”, Composites B, 38, 301–305 (2007) 10.1016/j.compositesb.2006.05.006Search in Google Scholar
Wu, L. B., Zhang, H., Zhang, J. C. and Ding, J. D., “Fabrication of Three-Dimensional Porous Scaffolds of Complicated Shape for Tissue Engineering. I. Compression Molding Based on Flexible-rigid Combined Mold”, Tissue Engineering, 11, 1105–1114 (2005) 10.1089/ten.2005.11.1105Search in Google Scholar PubMed PubMed Central
Wu, L. B., Jing, D. Y. and Ding, J. D., “A “Room-Temperature” Injection Molding/Particulate Leaching Approach for Fabrication of Biodegradable Three-Dimensional Porous Scaffolds”, Biomaterials, 27, 185–191 (2006) 10.1016/j.biomaterials.2005.05.105Search in Google Scholar PubMed
Yu, H. Y., Matthew, H. W., Wooley, P. H. and Yang, S. Y., “Effect of Porosity and Pore Size on Microstructures and Mechanical Properties of Poly-∊-caprolactone-Hydroxyapatite Composites”, J. Biomed. Mater. Res. B: Appl. Biomater., 86B, 541–547 (2008) 10.1002/jbm.b.31054Search in Google Scholar PubMed
Yuan, M. J., Turng, L. S., Gong, S. Q., Caulfield, D., Hunt, C. and Sprindler, R., “Study of Injection Molded Microcellular Polyamide-6 Nanocomposites”, Polym. Eng. Sci., 44, 673–686 (2004) 10.1002/pen.20061Search in Google Scholar
Yuan, M. J., Winardi, A., Gong, S. Q. and Turng, L. S., “Effects of Nano- and Micro-Fillers and Processing Parameters on Injection-Molded Microcellular Composites”, Polym. Eng. Sci., 45, 773–788 (2005) 10.1002/pen.20327Search in Google Scholar
Zhang, J. C., Wu, L. B., Jing, D. Y. and Ding, J. D., “A Comparative Study of Porous Scaffolds with Cubic and Spherical Macropores”, Polymer, 46, 4979–4985 (2005) 10.1016/j.polymer.2005.02.120Search in Google Scholar
Zhang, K., Wang, Y. B., Hillmyer, M. A. and Francis, L. F., “Processing and Properties of Porous Poly(L-lactide)/Bioactive Glass Composites”, Biomaterials, 25, 2489–2500 (2004) 10.1016/j.biomaterials.2003.09.033Search in Google Scholar PubMed
© 2014, Carl Hanser Verlag, Munich
Articles in the same Issue
- Contents
- Contents
- Invited Papers
- Simha-Somcynsky Equation of State Modeling of the PVT Behavior of PP/Clay-Nanocomposite/CO2 Mixtures
- Regular Contributed Articles
- Effect of Pre-Molding Process and Additive of Injection Molded Wood/PP Composites
- Flame Retarded PE with MH/ATH/Microencapsulated Red Phosphorous and its Toughening by Polymeric Compatibilizers
- The Porous Structure and Mechanical Properties of Injection Molded HA/PA66 Scaffolds
- A Gas-Sensor-Based Measurement Setup for Inline Quality and Process Control in Polymer Extrusion
- Extrusion and Characterization of Soy Protein Film Incorporated with Soy Cellulose Microfibers
- Development of Composites of Highly Filled Phenol Formaldehyde Resin – Coconut (Cocos nucifera) Endocarp Particles
- Structural Analysis Examining the Mold Deformation Behavior for the Detection of the Flash in the Injection Mold
- Epoxidized Esters of Palm Kernel Oil as an Effective Plasticizer for PVC: A Study of Mechanical Properties and Effect of Processing Conditions
- Injection Molding of Beverage Container Caps Made of a Composite Consisting of Wood Cellulose Fiber and an Ethylene-Acrylic Acid Copolymer
- Study on Pumping Conveying Capacity Characteristics of Polymer Solids in Vane Extruder
- Morphology Control and Stabilization in Immiscible Polypropylene and Polyamide 6 Blends with Organoclay
- Optimization of Abrasive Water Jet Turning Parameters for Machining of Low Density Polyethylene Material Based on Experimental Design Method
- PPS News
- PPS News
- Seikei Kakou Abstracts
- Seikei Kakou Abstracts
Articles in the same Issue
- Contents
- Contents
- Invited Papers
- Simha-Somcynsky Equation of State Modeling of the PVT Behavior of PP/Clay-Nanocomposite/CO2 Mixtures
- Regular Contributed Articles
- Effect of Pre-Molding Process and Additive of Injection Molded Wood/PP Composites
- Flame Retarded PE with MH/ATH/Microencapsulated Red Phosphorous and its Toughening by Polymeric Compatibilizers
- The Porous Structure and Mechanical Properties of Injection Molded HA/PA66 Scaffolds
- A Gas-Sensor-Based Measurement Setup for Inline Quality and Process Control in Polymer Extrusion
- Extrusion and Characterization of Soy Protein Film Incorporated with Soy Cellulose Microfibers
- Development of Composites of Highly Filled Phenol Formaldehyde Resin – Coconut (Cocos nucifera) Endocarp Particles
- Structural Analysis Examining the Mold Deformation Behavior for the Detection of the Flash in the Injection Mold
- Epoxidized Esters of Palm Kernel Oil as an Effective Plasticizer for PVC: A Study of Mechanical Properties and Effect of Processing Conditions
- Injection Molding of Beverage Container Caps Made of a Composite Consisting of Wood Cellulose Fiber and an Ethylene-Acrylic Acid Copolymer
- Study on Pumping Conveying Capacity Characteristics of Polymer Solids in Vane Extruder
- Morphology Control and Stabilization in Immiscible Polypropylene and Polyamide 6 Blends with Organoclay
- Optimization of Abrasive Water Jet Turning Parameters for Machining of Low Density Polyethylene Material Based on Experimental Design Method
- PPS News
- PPS News
- Seikei Kakou Abstracts
- Seikei Kakou Abstracts