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Aqueous soluble gold nanoparticle synthesis using polyethyleneimine and reduced glutathione

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Published/Copyright: October 10, 2014
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International Journal of Materials Research
From the journal International Journal of Materials Research Volume 105 Issue 10

Abstract

Gold nanoparticles (AuNPs) are considered to be ideal drug delivery vehicles for chemotherapeutic molecules due to the bio-inert nature of the colloids. Critical factors which determine the cellular internalization and intracellular localization of AuNPs are nanoparticle size as well as surface charge. Polydisperse AuNPs with a cationic surface charge, rich in primary amines would present multiple covalent molecule attachment loci and would be ideal for the delivery of chemotherapeutics which have multiple intracellular sites of action. In an adapted synthesis method, polydisperse cationic AuNPs were produced which were soluble in aqueous solution and showed high chemical stability. The synthesis was conducted in a comparative manner using polyethyleneimine (PEI) and reduced glutathione (GSH) as AuNP surface passivation ligands. Anisotropic as well as spherical morphologies were observed for the PEI passivated AuNPs, where the morphology was dependent on the ratio of reducing agent to Au3+ in solution. Only spherical morphologies were observed when GSH was used as the passivation ligand under similar conditions. The surface chemistry of the AuNPs was characterized by means of attenuated total reflectance spectroscopy and elemental composition was determined using energy dispersive X-ray spectroscopy. The PEI AuNPs surface was nitrogen rich, cationic and provided multiple covalent primary amine attachment points for downstream surface tailoring.

Keywords: Gold nanoparticles; Polyethyleneimine; Glutathione; Sodium borohydride; Anisotropic
* Correspondence address, Dr Francois Taute (Ph.D), North-West University (Potchefstroom Campus), P.O. Box 269, Private bag x6001, Potchefstroom 2530, North-West Province, South Africa, Tel: +27 72 377 4669, E-mail:

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Received: 2014-02-02
Accepted: 2014-05-05
Published Online: 2014-10-10
Published in Print: 2014-10-14

© 2014, Carl Hanser Verlag, München

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https://doi.org/10.3139/146.111114
Keywords for this article
Gold nanoparticles; Polyethyleneimine; Glutathione; Sodium borohydride; Anisotropic

Articles in the same Issue

  1. Contents
  2. Contents
  3. Original Contributions
  4. Phase equilibria studies of the “MnO”–Al2O3–SiO2 system in equilibrium with metallic alloy. Part 1: Development of the technique and determination of liquidus isotherms between 1 423 K and 1 523 K
  5. Casting process optimization of a bimetal wear-resistant block using liquid–solid processing
  6. Characteristics of melt convection during Kyropoulos sapphire crystal growth
  7. A method for the formation of intergranular crystalline phases in liquid phase sintering
  8. Corrosion resistance of laser treated titanium alloy with B4C particles at the surface
  9. Effect of Cr and Mo doping on the electrochemical properties of freeze-dried LiCoO2
  10. Inhibition properties and adsorption behavior of olive leaf extract on N80 carbon steel in CO2-saturated brine solution
  11. Tribological behavior of Fe3Al-60 wt.% Fe3AlC0.5 composite under air and vacuum conditions
  12. Improving the surface topography of mild steel with the burnishing process
  13. Additional small-scale boundary effects on free vibration of carbon nanotubes and their macroscopic energy meaning
  14. Aqueous soluble gold nanoparticle synthesis using polyethyleneimine and reduced glutathione
  15. DGM News
  16. Personal
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