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Influence of mineralized collagen fibrils on the thermo-sensitivity of an injectable scaffold for bone regeneration

  • Zhi Huang , Xiaoming Li , Qingling Feng , Ziqin Rong and Bo Yu
Published/Copyright: June 11, 2013
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International Journal of Materials Research
From the journal International Journal of Materials Research Volume 102 Issue 11

Abstract

Mineralized collagen fibrils are the basis for various connective tissues such as bone and cartilage. Injectable biomaterials incorporating mineralized collagen fibrils are applicable to a wide variety of implant types for bone regeneration. A mineralized collagen fibrils/chitosan thermo-sensitive and injectable scaffold for bone regeneration was prepared successfully. The thermo-sensitive properties of the mineralized collagen fibrils/chitosan system depended on the concentrations of mineralized collagen fibrils. 0.02 g mL−1 of mineralized collagen fibrils filler was appropriate for application since it allowed lower gelation temperature and more rapid gelation following injection, due to the increased hydrogen bonds between the collagen in mineralized collagen fibrils and chitosan.

Keywords: Mineralized collagen; Chitosan; Bone; Thermo-sensitive; Injectable
* Correspondence address, Prof. Qingling Feng, Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, China, Tel.: +86 10 62 782 770, Fax: +86 10 62 771 160, E-mail:

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Received: 2010-07-15
Accepted: 2011-08-31
Published Online: 2013-06-11
Published in Print: 2011-11-01

© 2011, Carl Hanser Verlag, München

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https://doi.org/10.3139/146.110594
Keywords for this article
Mineralized collagen; Chitosan; Bone; Thermo-sensitive; Injectable

Articles in the same Issue

  1. Contents
  2. Contents
  3. Editorial
  4. Changes in the Editorial Office of IJMR
  5. Original Contributions
  6. Influence of the nature of an electric field applied during the solution heat treatment of the Al-Mg-Si-Cu Alloy AA6111 on subsequent natural aging
  7. Isothermal dynamic thermal diffusivity studies of the reduction of NiO and NiWO4 precursors by hydrogen
  8. Heating rate effects on reverse martensitic transformation in a Cu – Zn – Al shape memory alloy
  9. Effect of Ce content on the microstructure of semisolid Mg-10Al alloy
  10. Dielectric properties of low-temperature sintered Ba(Fe0.5Nb0.5)O3 with BaCu(B2O5) addition
  11. Recovery stress and shape memory stability in Ni–Ti–Cu thin wires at high temperatures
  12. Microstructure and mechanical properties of WC-Ni-Al based cemented carbides developed for engineering applications
  13. Microstructure of austenitic stainless steels of various phase stabilities after cyclic and tensile deformation
  14. High temperature workability behaviour of a modified P92 steel
  15. Influence of mineralized collagen fibrils on the thermo-sensitivity of an injectable scaffold for bone regeneration
  16. Low temperature synthesis of CuGeO3 nanoflowers from n-heptane solvent
  17. Preparation of Zn1–xMnxO nanoparticles by a simple “green” method and photocatalytic activity under visible light irradiation
  18. Surface morphology, electrical and optical properties n-type doped MOCVD grown GaSb using dimethyltellurium
  19. The role of polymethylhydrosiloxane in the sol-gel synthesis of high surface area porous silicon carbide
  20. Synthesis, characterization and dehydration–rehydration study of sol-gel derived hydroxide hydrogel of the MgO–ZrO2 system
  21. DGM News
  22. DGM News
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