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Experimental study of natural circulation flow instability in rectangular channels

  • T. Zhou , S. Qi EMAIL logo , M. Song and Z. Xiao
Published/Copyright: February 28, 2022
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Abstract

Experiments of natural circulation flow instability were conducted in rectangular channels with 5 mm and 10 mm wide gaps. Results for different heating powers were obtained. The results showed that the flow will tend to be instable with the growing of heating power. The oscillation period of pressure D-value and volume flow are the same, but their phase positions are opposite. They both can be described by trigonometric functions. The existence of edge position and secondary flow will strengthen the disturbance of fluid flow in rectangle channels, which contributes to heat transfer. The disturbance of bubble and fluid will be strengthened, especially in the saturated boiling section, which make it possible for the mixing flow. The results also showed that the resistance in 5 mm channel is bigger than that in 10 mm channel, it is less likely to form stable natural circulation in the subcooled region.

Abstract

Experimentelle Untersuchungen der Strömungsinstabilität von Naturumlaufsystemen wurden in rechteckigen Kanälen mit 5 mm und 10 mm Abständen durchgeführt. Es wurden Ergebnisse für verschiedene Wärmeleistungen erhalten. Die Ergebnisse zeigen, dass die Strömung mit wachsender Wärmeleistung zur Instabilität neigt. Die Schwingungsperioden von Druckschwankungen und Volumenstrom sind gleich, aber ihre Phasenpositionen sind entgegengesetzt. Beide können durch trigonometrische Funktionen beschrieben werden. Das Vorhandensein von Randlagen und einer Sekundärströmung verstärkt die Störung der Flüssigkeitsströmung in rechteckigen Kanälen, was zum Wärmetransfer beiträgt. Die Störung von Blasen und Flüssigkeit verstärkt sich, insbesondere beim gesättigten Sieden. Die Ergebnisse zeigen auch, dass der Widerstand in einem 5 mm Kanal größer ist als in einem 10 mm Kanal. Es ist deshalb weniger wahrscheinlich in der unterkühlten Region einen stabilen Naturumlauf zu bilden.

Acknowledgements

(1) CNNC Key Laboratory on Nuclear Reactor Thermal Hydraulics Technology Foundation (20130901); (2) Natural Science Foundation of China (50976033).

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Books · Bücher

Cyclotron Produced Radionuclides: Emerging Positron Emitters for Medical Applications: 64Cu and 124I. IAEA Radioisotopes and Radiopharmaceuticals Reports No. 1, Published by the International Atomic Energy Agency 2016, ISBN 978-920-109615-9, 63 pp., 38.00 EUR.

The application of radionuclides in medicine has undergone significant growth in the last two decades, with the availability of a large number of cyclotrons exclusively dedicated to their production contributing to this growth. The widespread use of positron emission tomography (PET) in oncology and the rapid dissemination of PET-computed tomography (PET-CT) cameras throughout the world have revolutionized nuclear medicine.

New radiopharmaceuticals which can be routinely used for diagnosis or for evaluation of cancer therapy would be valuable additions to the arsenal available. There is great potential for production and development of new radiopharmaceuticals using PET radionuclides other than 18F and 11C at most of the present day medical cyclotron facilities with cyclotrons in the energy range of 10 – 20 MeV. Cyclotron time is usually available for research, but there are several other factors to be addressed in the development and use of new radiopharmaceuticals. More than 30 potentially useful cyclotron produced positron emitting radionuclides have been reported, and 64Cu and 124I in particular have received considerable attention. Because of low positron energy, low abundance of gamma radiation, suitable half-life and favourable coordination chemistry, these radionuclides are attracting widespread interest. There are two major challenges in wider production of these PET tracers:

  1. The targets for the production of these radionuclides are not widely available or are considered too difficult to use.

  2. The separation of the radionuclide from the target material requires ion exchange chromatography or thermal diffusion and the labelling efficiency of the resultant nuclide needs to be further developed.

This IAEA publication was initiated following a coordinated research project (CRP) on “Production and Utilisation of Emerging Positron Emitters for Medical Applications with an Emphasis on 64Cu and 124I” with participation of 15 institutions worldwide and with the aim to enhance the capability of Member States in production of emerging positron emitters for medical applications in order to meet the demand for new PET based diagnostic agents for specific diseases and provide improved dosimetry of therapeutic radionuclides. This publication is intended to provide broad information (with ample references for those who wish to go deeper) on better production routes and better separation and purification of these PET radionuclides so as to achieve high specific activity and chemical purity suitable for labelling molecules of medical interest and also enable fruitful use of the spare capacity available in medical cyclotron centres.

Guidance provided here, describing good practices, represents expert opinion but does not constitute recommendations made on the basis of a consensus of Member States.

This publication provides methods and guidelines on development of targets (making use of standardized nuclear data) capable of producing sufficient quantities of 64Cu and 124I for clinical investigations, chemistry for the separation of radionuclides from target materials to improve extraction and purity of the radionuclides and to minimize metal contaminants which might reduce the labelling efficiency, and development of new radiopharmaceuticals labelled with these non-standard PET radionuclides.

This publication contains sections on production of 64Cu and 124I; techniques for preparation of targets, irradiation of targets under high beam currents, target processing and target recovery; and conclusions. The accompanying CD-ROM, which supports the book, contains accounts of the participants’ work during the CRP demonstrating the successful application of the principles described in the publication. These are the unedited reports of the CRP participants as presented at the final research coordination meeting.

Received: 2016-06-26
Published Online: 2022-02-28

© 2017 Carl Hanser Verlag GmbH & Co. KG

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