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Benzalkonium Salts of Amino Acids – Physicochemical Properties and Anti-Microbial Activity

  • Paula Ossowicz , Ewa Janus , Magdalena Błaszak , Kinga Zatoń and Zbigniew Rozwadowski
Published/Copyright: November 13, 2017
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Tenside Surfactants Detergents
From the journal Tenside Surfactants Detergents Volume 54 Issue 6

Abstract

New salts combining a benzalkonium cation and chiral amino acid anions were synthesized and characterized. The identification was performed by NMR spectroscopy. Properties such as temperature of phase transformation, specific rotation, thermal stability and surface activity and antimicrobial activity were determined and compared with that of benzalkonium chloride. Benzalkonium amino acids salts can be used as conditioners in cosmetics. It has been shown they have weak impact on symbiotic microorganisms which occupy a wide range of skin, and this confirms that they do not disturb the biological balance of human skin.

Kurzfassung

Neue Salze, die aus einem Benzalkoniumkation und chiralen Aminosäureanionen bestehen, wurden synthetisiert und charakterisiert. Die Identifizierung erfolgte durch NMR-Spektroskopie. Eigenschaften wie die Phasenumwandlungstemperatur, die spezifische Rotation, die thermische Stabilität, die Oberflächenaktivität und die antimikrobielle Aktivität wurden bestimmt und mit denen von Benzalkoniumchlorid verglichen. Die Benzalkonium-Aminosäure-Salze können als Konditionierer in der Kosmetik verwendet werden. Es wurde gezeigt, dass sie einen schwachen Einfluss auf die symbiotischen Mikroorganismen haben, die einen weiten Bereich der Haut einnehmen. Dies bestätigt, dass sie das biologische Gleichgewicht der menschlichen Haut nicht stören.

Key words: Benzalkonium salts; amino acids; surface activity; biological activity
Stichwörter: Benzalkoniumsalze; Aminosäuren; Oberflächenaktivität; biologische Aktivität
*Correspondence address, Dr. Paula Ossowicz, Institute of Organic Chemical Technology, Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology Szczecin, ul. Pułaskiego 10, 70-322 Szczecin, Poland, Tel.: +48914494584, Fax: +48914494365, E-Mail:

Paula Ossowicz – Ph. D., (Eng.), graduated from the Faculty of Chemical Engineering and Technology, West Pomeranian University of Technology in Szczecin (2011). In 2015, she received a degree of doctor from the same Faculty. Currently, she works as a researcher at the Institute of Organic Chemical Technology of West Pomeranian University of Technology in Szczecin. Her research interest encompasses novel compounds with application as medicinal and surface active remedies.

Ewa Janus – Ph. D., D. Sc., (Eng.), graduated from the Faculty of Chemical Technology and Engineering of Szczecin University of Technology (1994). She was granted the title of the Doctor of Technical Sciences in 1999, while in 2014 she was granted D.Sc. in the field of chemical technology. She works at the Institute of Organic Chemical Technology of West Pomeranian University of Technology in Szczecin. Scientific interests – ionic liquids – synthesis, properties and applications in technology and organic synthesis.

Magdalena Błaszak – Ph. D., D.Sc., (Eng.), works at the Department of Chemistry, Microbiology and Environmental Biotechnology of West Pomeranian University of Technology in Szczecin. She was granted the title of the Doctor of Agriculture Sciences, while in 2014 she was granted D.Sc. in the field of environmental microbiology.

Kinga Zatoń is Ph. D. student at the Department of Chemistry, Microbiology and Environmental Biotechnology of West Pomeranian University of Technology in Szczecin.

Zbigniew Rozwadowski – Ph. D., D.Sc., (Eng.), graduated from the Faculty of Chemical Technology and Engineering of Szczecin University of Technology (1993). He was granted the title of the Doctor of Chemical Sciences in 2000, while in 2010 he was granted D.Sc. in the field of chemistry. He works at the Department of Inorganic and Analytical Chemistry of West Pomeranian University of Technology in Szczecin. Specialty – organic chemistry.

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Received: 2017-05-11
Accepted: 2017-08-12
Published Online: 2017-11-13
Published in Print: 2017-11-15

© 2017, Carl Hanser Publisher, Munich

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https://doi.org/10.3139/113.110524
Keywords for this article
Benzalkonium salts; amino acids; surface activity; biological activity

Articles in the same Issue

  1. Contents/Inhalt
  2. Contents
  3. Application
  4. The Influence of Natural and Synthetic Additives in Mitigating Calcium Phosphate Scale in Industrial Water Systems
  5. Preparation and Application of Double-Hydrophilic Copolymer as Scale and Corrosion Inhibitor for Industrial Water Recycling
  6. Removal of Insoluble Slimes from Potash Ore Using Flotation
  7. Ester-Based Pyridinium Gemini Surfactants as Novel Inhibitors for Mild Steel Corrosion in 1 M HCl Solution
  8. Novel Surfactants
  9. Benzalkonium Salts of Amino Acids – Physicochemical Properties and Anti-Microbial Activity
  10. Synthesis, Characterizations and Multifunctional Activities of New Thiourea-Based Non-Ionic Surfactants
  11. Environmental Chemistry
  12. Extraction of Natural Surfactant Saponin from Soapnut (Sapindus mukorossi) and its Utilization in the Remediation of Hexavalent Chromium from Contaminated Water
  13. Electrocatalytic Hydrogenolysis of Chlorophenolic Compounds by Modified Electrodes in Aqueous Medium in the Absence and the Presence of Ionic Surfactant
  14. Physical Chemistry
  15. Enzymatic Synthesis and Characterization of Sucrose Erucate
  16. Study of the Complex System of Fatty Alcohol Polyoxyethylene Ether Carboxylate and Alkyl Betaine for Heavy Oil Recovery
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