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Effect of Sodium Taurocholate on Aggregation Behavior of Amphiphilic Drug Solution

  • Dileep Kumar and Malik Abdul Rub
Published/Copyright: January 7, 2016
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Tenside Surfactants Detergents
From the journal Tenside Surfactants Detergents Volume 52 Issue 6

Abstract

The aggregation behavior of promazine hydrochloride (PMZ) and bile salt (sodium taurocholate (NaTC)) mixtures at various compositions and temperature in pure and mixed states were studied using conductometry technique in aqueous solutions. The values of experimental and ideal critical micelle concentration (cmc and cmcid) propose attractive interactions in PMZ-NaTC mixtures. By applying the regular solution theory (RST) various physicochemical parameter such as micellar mole fraction in the mixed (X1) and ideal (X1id) state, interaction parameters (β), thermodynamic parameters of micellization as well as other related parameters have been evaluated and discussed in detail. The results show that the synergistic effect between drug and bile salt plays a crucial role in the redtdprefuction of the overall cmc value in aqueous solution at various composition of NaTC. The thermodynamic parameters recommend the discharge of water from the hydrophobic part of the PMZ at higher temperatures.

Kurzfassung

Es wurde das Aggregationsverhalten wässriger Mischungen aus Promazinhydrochlorid (PMZ) und Gallensalz (Natriumtaurochlorat, NaTC) bei verschiedenen Zusammensetzungen und das der reinen wässrigen Komponenten konduktometrisch bei verschiedenen Temperaturen bestimmt. Die experimentell bestimmten und die idealen kritischen Mizellenbildungskonzentrationen (cmc und cmcid) weisen auf anziehende Wechselwirkungen in den PMZ-NaTC-Mischungen hin. Unter Anwendung der Theorie der regulären Lösungen (regular solution theory, RST) konnten verschiedene physico-chemische Parameter wie die mizellaren Molenbrüche im Misch- (X1) und im idealen (X1id) System, die Wechselwirkungsparameter (β), die thermodynamischen Parameter der Mizellisierung, sowie weitere damit verbundene Parameter berechnet und detailliert diskutiert werden. Die Ergebnisse zeigen, dass der synergistische Effekt zwischen Wirkstoff und dem Gallensalz eine entscheidende Rolle bei der Reduktion der Gesamt-cmc in den wässrigen Lösungen mit verschiedenen NaTC-Konzentrationen spielt. Die thermodynamischen Parameter weisen auf einen Austritt von Wasser aus dem hydrophoben Teil des PMZ bei höheren Temperaturen hin.

Key words: Promazine hydrochloride; PMZ; critical micelle concentration; cmc; sodium taurocholate; activity coefficient; Thermodynamic parameters
Stichwörter: Promazinhydrochlorid; PMZ; kritische Mizellenbildungskonzentration; cmc; Natriumtaurochlorat; Aktivitätskoeffizient; thermodynamische Parameter
*Correspondence address, Dr. Dileep Kumar, Faculty of Science, Universiti Tunku Abdul Rahman, 31900 Kampar, Perak, Malaysia. Tel.: +601112464449. E-Mail:

Dr. Dileep Kumar received his M.Sc. and Ph.D. degrees from Aligarh Muslim University, (AMU) Aligarh. Currently, he is a Post Doc Fellow in Faculty of Science, Universiti Tunku Abdul Rahman, 31900 Kampar, Perak, Malaysia. His current research interests are chemical kinetics, catalysis and mixed amphiphile systems.

Dr. Malik Abdul Rub received his M.Sc. and Ph.D. degrees from the Aligarh Muslim University. Now he has joined King Abdulaziz University as an Assistant Professor in the Chemistry Department. His current research interests are mixed micellization study of amphiphilic drugs with different additives and clouding phenomenon in amphiphilic systems.

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Received: 2015-04-28
Accepted: 2015-06-24
Published Online: 2016-01-07
Published in Print: 2015-11-16

© 2015, Carl Hanser Publisher, Munich

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https://doi.org/10.3139/113.110398
Keywords for this article
Promazine hydrochloride; PMZ; critical micelle concentration; cmc; sodium taurocholate; activity coefficient; Thermodynamic parameters

Articles in the same Issue

  1. Contents/Inhalt
  2. Contents
  3. Hygiene and Washing
  4. Characterization of Microbial Communities in Household Washing Machines
  5. Hygiene in Domestic Laundering – Consumer Behavior in Germany
  6. Timesaving Washing of Textiles Utilizing 38 kHz Ultrasound
  7. Application
  8. Oil Extraction from Oil-Contaminated Drill Cuttings Using a Recyclable Single-Phase O/W Microemulsion
  9. Physical Chemistry
  10. Effect of Sodium Taurocholate on Aggregation Behavior of Amphiphilic Drug Solution
  11. Influence Prediction of Alkylamines Upon Electrical Percolation of AOT-based Microemulsions Using Artificial Neural Networks
  12. Effect of Tween 40 and Tween 60 on the Properties of a Cationic Slow-Set Emulsifier
  13. Magnetic Properties of Polyaniline/ZFe2O4 Nanocomposites Synthesized in CTAB as Surfactant and Ionic Liquid
  14. Novel Surfactants
  15. Ionic Liquid in Thin-Layer Chromatography of Anionic Surfactants: Selective Separation of Sodium Deoxycholate and Identification in Commercial Products
  16. Micellar Catalysis
  17. Combination of Best Promoter and Micellar Catalyst for Chromic Acid Oxidation of D-Arabinose in Aqueous Media at Room Temperature
  18. Environmental Chemistry
  19. Photocatalytic Degradation of Copper(II) Palmitates in Non Aqueous Media Using ZnO as Photocatalyst
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