Home Effect of Sodium Taurocholate on Aggregation Behavior of Amphiphilic Drug Solution
Article
Licensed
Unlicensed Requires Authentication

Effect of Sodium Taurocholate on Aggregation Behavior of Amphiphilic Drug Solution

  • Dileep Kumar and Malik Abdul Rub
Published/Copyright: January 7, 2016
Become an author with De Gruyter Brill
Author Information
Tenside Surfactants Detergents
From the journal Tenside Surfactants Detergents Volume 52 Issue 6

Abstract

The aggregation behavior of promazine hydrochloride (PMZ) and bile salt (sodium taurocholate (NaTC)) mixtures at various compositions and temperature in pure and mixed states were studied using conductometry technique in aqueous solutions. The values of experimental and ideal critical micelle concentration (cmc and cmcid) propose attractive interactions in PMZ-NaTC mixtures. By applying the regular solution theory (RST) various physicochemical parameter such as micellar mole fraction in the mixed (X1) and ideal (X1id) state, interaction parameters (β), thermodynamic parameters of micellization as well as other related parameters have been evaluated and discussed in detail. The results show that the synergistic effect between drug and bile salt plays a crucial role in the redtdprefuction of the overall cmc value in aqueous solution at various composition of NaTC. The thermodynamic parameters recommend the discharge of water from the hydrophobic part of the PMZ at higher temperatures.

Kurzfassung

Es wurde das Aggregationsverhalten wässriger Mischungen aus Promazinhydrochlorid (PMZ) und Gallensalz (Natriumtaurochlorat, NaTC) bei verschiedenen Zusammensetzungen und das der reinen wässrigen Komponenten konduktometrisch bei verschiedenen Temperaturen bestimmt. Die experimentell bestimmten und die idealen kritischen Mizellenbildungskonzentrationen (cmc und cmcid) weisen auf anziehende Wechselwirkungen in den PMZ-NaTC-Mischungen hin. Unter Anwendung der Theorie der regulären Lösungen (regular solution theory, RST) konnten verschiedene physico-chemische Parameter wie die mizellaren Molenbrüche im Misch- (X1) und im idealen (X1id) System, die Wechselwirkungsparameter (β), die thermodynamischen Parameter der Mizellisierung, sowie weitere damit verbundene Parameter berechnet und detailliert diskutiert werden. Die Ergebnisse zeigen, dass der synergistische Effekt zwischen Wirkstoff und dem Gallensalz eine entscheidende Rolle bei der Reduktion der Gesamt-cmc in den wässrigen Lösungen mit verschiedenen NaTC-Konzentrationen spielt. Die thermodynamischen Parameter weisen auf einen Austritt von Wasser aus dem hydrophoben Teil des PMZ bei höheren Temperaturen hin.

Key words: Promazine hydrochloride; PMZ; critical micelle concentration; cmc; sodium taurocholate; activity coefficient; Thermodynamic parameters
Stichwörter: Promazinhydrochlorid; PMZ; kritische Mizellenbildungskonzentration; cmc; Natriumtaurochlorat; Aktivitätskoeffizient; thermodynamische Parameter
*Correspondence address, Dr. Dileep Kumar, Faculty of Science, Universiti Tunku Abdul Rahman, 31900 Kampar, Perak, Malaysia. Tel.: +601112464449. E-Mail:

Dr. Dileep Kumar received his M.Sc. and Ph.D. degrees from Aligarh Muslim University, (AMU) Aligarh. Currently, he is a Post Doc Fellow in Faculty of Science, Universiti Tunku Abdul Rahman, 31900 Kampar, Perak, Malaysia. His current research interests are chemical kinetics, catalysis and mixed amphiphile systems.

Dr. Malik Abdul Rub received his M.Sc. and Ph.D. degrees from the Aligarh Muslim University. Now he has joined King Abdulaziz University as an Assistant Professor in the Chemistry Department. His current research interests are mixed micellization study of amphiphilic drugs with different additives and clouding phenomenon in amphiphilic systems.

References

1. Schreier, S., Malheiros, S. V. P. and de Paula, E.: Biochim. Biophys. Acta1508 (2000)) 210. 10.1016/S0304-4157(00)00012-5Search in Google Scholar

2. Kabir-ud-Din, Naqvi, A. Z., and Khan, A. B.: Tenside Surf. Detergents47 (2010)) 318. 10.3139/113.110084Search in Google Scholar

3. Azum, N., Rub, M. A. and Asiri, A. M.: J. Mol. Liquids196 (2014)) 14. 10.1016/j.molliq.2014.03.008Search in Google Scholar

4. Rub, M. A., Asiri, A. M., Azum, N., Khan, A., Khan, A. A. P. and Kabir-ud-Din: Tenside Surf. Detergents50 (2013)) 376. 10.3139/113.110270Search in Google Scholar

5. Azum, N., Rub, M. A. and Asiri, A. M.: Colloids Surf. B121 (2014)) 158. 10.1016/j.colsurfb.2014.06.009Search in Google Scholar PubMed

6. Rub, M. A., Khan, F., Kumar, D. and Asiri, A. M.: Tenside Surf. Detergents52 (2015)) 236. 10.3139/113.110371Search in Google Scholar

7. Torchilin, V. P.: Cell. Mol. Life Sci.61 (2004)) 2549. 10.1007/s00018-004-4153-5Search in Google Scholar PubMed

8. Caetano, W. and Tabak, M.: J. Colloid Interface Sci.225 (2000)) 69. 10.1006/jcis.2000.6720Search in Google Scholar PubMed

9. Mahajan, R. K., Mahajan, S., Bhadani, A. and Singh, S.: Phys. Chem. Chem. Phys.14 (2012)) 887,. 10.1039/c1cp22448dSearch in Google Scholar PubMed

10. Rub, M. A., Asiri, A. M., Khan, J. M., Khan, F. and Khan, R. H.: J. Taiwan Institute Chem. Eng.45 (2014)) 2068. 10.1016/j.jtice.2014.04.024Search in Google Scholar

11. Mahajan, S. and Mahajan, R. K.: Adv. Colloid Interface Sci.199–200 (2013)) 1. 10.1016/j.cis.2013.06.008Search in Google Scholar PubMed

12. Azum, N., Rub, M. A. and Asiri, A. M.: Pharmaceutical Chem. J.48 (2014)) 201. 10.1007/s11094-014-1077-8Search in Google Scholar

13. Kaushal, D., Rana, D. S., Chauhan, M. S., Umar, A. and Chauhan, S.: J. Mol. Liq.188 (2013)) 237. 10.1016/j.molliq.2013.09.030Search in Google Scholar

14. Rub, M. A., Azum, N., Kumar, D., Asiri, A. M. and Marwani, H. M.: J. Chem. Thermodyn.74 (2014)) 91,. 10.1016/j.jct.2014.01.005Search in Google Scholar

15. Gokturk, S. and Aslan, S.: J. Dispersion Sci. Technol.35 (2014)) 84,. 10.1080/01932691.2013.775583Search in Google Scholar

16. Attwood, D. and Florence, A. T.: Surfactant Systems: Their Chemistry, Pharmacy and Biology, New York, Chapman (1983). 10.1007/978-94-009-5775-6. 10.1007/978-94-009-5775-6Search in Google Scholar

17. O’Connor, C. J. and Wallace, R. G.: Adv. Colloid Interface Sci.22 (1985)) 1,. 10.1016/0001-8686(85)80002-6Search in Google Scholar

18. Maldonado-Valderrama, J., Wilde, P., Macierzank, A. and Mackie, A.: Adv. Colloid Interface Sci.165 (2011)) 36,. 10.1016/j.cis.2010.12.002Search in Google Scholar PubMed

19. Hofmann, A. F.: Bile Acids in Hepatobiliary Disease, edited by Northfield, T. C., Ahmed, H., Jazrawi, R., and Zentler-Munro, P. L., Boston, Kluwer (1999). ISBN: 0-7923-8755-4.Search in Google Scholar

20. Small, D. M.: The Bile Acids: Chemistry, Physiology and Metabolism, edited by Nair, P. P. and Kritchevsky, D., vol. 1, New York, Plenum (1971). ISBN: 978-1-4757-0649-9.Search in Google Scholar

21. Madenci, D. and Egelhaaf, S. U.: Curr. Opin. Colloid Interface Sci.15 (2010)) 109. 10.1016/j.cocis.2009.11.010Search in Google Scholar

22. Weber, L. P. and Lanno, R. P.: Environ. Toxicol. Chem.20 (2001)) 1117. 10.1002/etc.5620200525Search in Google Scholar

23. Hildebrand, A., Neubert, R., Garidel, P. and Blume, A.: Langmuir18 (2002)) 2836. 10.1021/la011421cSearch in Google Scholar

24. Ninomiya, R., Matsuoka, K. and Moroi, Y.: Biochim. Biophys. Acta1634 (2003)) 116. 10.1016/j.bbalip.2003.09.003Search in Google Scholar PubMed

25. Ross, B. P., Braddy, A. C., McGeary, R. P., Blanchfield, J. T., Prokai, L. and Toth, I.: Mol. Pharmaceutics1 (2004)) 233. 10.1021/mp049964dSearch in Google Scholar PubMed

26. Zana, R. and Guveli, D.: J. Phys. Chem.89 (1985)) 1687. 10.1021/j100255a028Search in Google Scholar

27. Li, G. and McGown, L. B., J. Phys. Chem.98 (1994)) 13711. 10.1021/j100102a043Search in Google Scholar

28. Rub, M. A., Asiri, A. M., Kumar, D., Azum, N. and Khan, F.: Acta Phys.-Chim. Sin.30 (2014)) 699. 10.3866/PKU.WHXB201402112Search in Google Scholar

29. Kumar, D., Rub, M. A., Akram, M. and Kabir-ud-Din: Tenside Surf. Detergents51 (2014)) 157. 10.3139/113.110296Search in Google Scholar

30. Rub, M. A., Asiri, A. M., Khan, J. M., Khan, R. H. and Kabir-ud Din: J. Mol. Struc.1050 (2013)) 35. 10.1016/j.molstruc.2013.07.010Search in Google Scholar

31. Kumar, D., Rub, M. A., Akram, M. and Kabir-ud Din: Spectrochimica Acta A132 (2014)) 288. 10.1016/j.saa.2014.05.002Search in Google Scholar PubMed

32. Barker, C. A., Saul, D., Tiddy, G. J. T., Wheeler, B. A. and Willis, E.: J. Chem. Soc., Faraday Trans. 170 (1974)) 154. 10.1039/F19747000154Search in Google Scholar

33. Vethamuthu, M. S., Almgren, M., Karlsson, G. and Bahadur, P.: Langmuir12 (1996)) 2173. 10.1021/la950964hSearch in Google Scholar

34. Elworthy, P. H., Florence, A. T. and Macfarlane, G. B.: Solubilization by Surface-Active Agents and Its Application in Chemistry and Biological Sciences, Suffolk, Chapman and Hall (1968). OCLC Number: 896700385.Search in Google Scholar

35. Jana, P. K. and Moulik, S. P.: J. Phys. Chem.95 (1991)) 9525. 10.1021/j100176a089Search in Google Scholar

36. Rub, M. A., Sheikh, M. S., Asiri, A. M., Azum, N., Khan, A., Khan, A. A. P., Khan, S. B. and Kabir-ud Din: J. Chem. Thermodynamics64 (2013)) 28. 10.1016/j.jct.2013.04.020Search in Google Scholar

37. Clint, J. H.: Surfactant Aggregation, New York, Blackie/Chapman and Hall (1992). 10.1007/978-94-011-2272-6Search in Google Scholar

38. Nonionic Surfactants: Physical Chemistry, edited by Schick, M. J., New York, Dekker (1987). 10.1080/01932699008943267Search in Google Scholar

39. Mosquera, V., del Rio, J. M., Attwood, D., Garcia, M., Jones, M. N., Prieto, G., Suarez, M. J. and Sarmiento, F.: J.: Colloid Interface Sci.206 (1998)) 66. 10.1006/jcis.1998.5708Search in Google Scholar PubMed

40. Kabir-ud-Din, Siddiqui, U. S., Kumar, S. and Dar, A. A.: Colloid Polym. Sci.284 (2006)) 807. 10.1007/s00396-005-1449-4Search in Google Scholar

41. Ruiz, C. C., Diaz-Lopez, L. and Aguiar, J.: J. Colloid Interface Sci.305 (2007)) 293. 10.1016/j.jcis.2006.09.074Search in Google Scholar PubMed

42. Chen, L.-J., Lin, S.-Y., and Huang, C.-C.: J. Phys. Chem. B102 (1998)) 4350. 10.1021/jp9804345Search in Google Scholar

43. Islam, M. N. and Kato, T.: J. Phys. Chem. B107 (2003)) 965. 10.1021/jp021212gSearch in Google Scholar

44. Lopez-Fontan, J. L., Costa, J., Ruso, J. M., Prieto, G. and Sarmiento, F.: J. Chem. Eng. Data49 (2004)) 1008. 10.1021/je049954lSearch in Google Scholar

45. Rub, M. A., Asiri, A. M., Naqvi, A. Z., Rahman, M. M., Khan, S. B. and Kabir-ud Din: J. Mol. Liqs.177 (2013)) 19. 10.1016/j.molliq.2012.10.003Search in Google Scholar

46. Zana, R.: J.ColloidInterface Sci.78 (1980)) 330. 10.1016/j.molliq.2012.10.003Search in Google Scholar

47. Mukerjee, P.: Adv. Colloid Interface Sci.1 (1967)) 242. 10.1016/j.molliq.2012.10.003Search in Google Scholar

48. Iijima, H., Kato, T. and Soderman, A.: Langmuir16 (2000)) 318. 10.1021/la9902688Search in Google Scholar

49. Asakawa, T., Kitano, H., Ohta, A. and Miyagishi, S.: J. Colloid Interface Sci.242 (2001)) 284. 10.1006/jcis.2001.7875Search in Google Scholar

50. Rubingh, D. N.: Solution Chemistry of Surfactants, edited by Mittal, K. L., New York, Plenum Press (1979). 10.1007/978-1-4615-7880-2Search in Google Scholar

51. Motomura, K., Yamanaka, M. and Aratono, M.: Colloid Polym. Sci.262 (1984)) 948. 10.1007/BF01490027Search in Google Scholar

52. Rodenas, V., Valiente, M. and Villafruela, M. S.: J. Phys. Chem. B103 (1999)) 4549. 10.1021/jp981871mSearch in Google Scholar

53. Lange, H. and Beck, K. H.: Kolloid Z. Z. Polym.251 (1973)) 424. 10.1007/BF01498689Search in Google Scholar

54. Peyre, V.: Langmuir18 (2002)) 1014. 10.1021/la0107345Search in Google Scholar

55. Makayssi, A., Lemordant, D. and Triener, C.: Langmuir9 (1993)) 2808. 10.1021/la00035a014Search in Google Scholar

56. Eads, C. D. and Robosky, L. C.: Langmuir15 (1999)) 2661. 10.1021/la980525tSearch in Google Scholar

57. Bergstrom, L. M. and Aratono, M.: Soft Matter7 (2011)) 8870. 10.1039/C1SM06064CSearch in Google Scholar

58. Rodriguez, J. L., Minardi, R. M., Schulz, E. P., Pieroni, O. and Schulz, P. C.: J. Surf. Deterg.15 (2012)) 147. 10.1007/s11743-011-1302-3Search in Google Scholar

59. Mixed Surfactant Systems, edited by Ogino, K. and Abe, M., New York, Marcel Dekker (1993). ISBN: 0-8247-8796-X.Search in Google Scholar

60. Liu, L. and Rosen, M. J.: J. Colloid Interface Sci.179 (1996)) 454. 10.1006/jcis.1996.0237Search in Google Scholar

61. Zhou, Q. and RosenM.J.: Langmuir19 (2003)) 4555. 10.1021/la020789mSearch in Google Scholar

62. Rub, M. A., Kumar, D., Azum, N., KhanF. and AsiriA. M.: J. Solution Chem.43 (2014)) 930. 10.1007/s10953-014-0174-3Search in Google Scholar

63. Rub, M. A., Sheikh, M. S., Khan, F., Khan, S. B. and Asiri, A. M.: Z. Phys. Chem.228 (2014)) 747. 10.1515/zpch-2013-0495Search in Google Scholar

64. Nusselder, J. J. H. and Engberts, J. B. F. N.: J. Colloid Interface Sci.148 (1992)) 353. 10.1016/0021-9797(92)90174-KSearch in Google Scholar

65. Hall, D. G.: J. Chem. Soc., Faraday Trans.87 (1991)) 3529. 10.1039/FT9918703529Search in Google Scholar

66. Azum, N., Rub, M. A., Asiri, A. M. and Marwani, H. M.: J. Mol. Liquids197 (2014)) 339. 10.1016/j.molliq.2014.06.009Search in Google Scholar

67. Rub, M. A., Azum, N., Khan, F., Al-Sehemi, A. G. and Asiri, A. M.: Korean J. Chem. Eng.32 (2015)) 2142. 10.1007/s11814-015-0019-9Search in Google Scholar

68. Maeda, H.: J. Phys. Chem. B109 (2005)) 15933. 10.1021/jp052082pSearch in Google Scholar PubMed

Received: 2015-04-28
Accepted: 2015-06-24
Published Online: 2016-01-07
Published in Print: 2015-11-16

© 2015, Carl Hanser Publisher, Munich

Articles in the same Issue

  1. Contents/Inhalt
  2. Contents
  3. Hygiene and Washing
  4. Characterization of Microbial Communities in Household Washing Machines
  5. Hygiene in Domestic Laundering – Consumer Behavior in Germany
  6. Timesaving Washing of Textiles Utilizing 38 kHz Ultrasound
  7. Application
  8. Oil Extraction from Oil-Contaminated Drill Cuttings Using a Recyclable Single-Phase O/W Microemulsion
  9. Physical Chemistry
  10. Effect of Sodium Taurocholate on Aggregation Behavior of Amphiphilic Drug Solution
  11. Influence Prediction of Alkylamines Upon Electrical Percolation of AOT-based Microemulsions Using Artificial Neural Networks
  12. Effect of Tween 40 and Tween 60 on the Properties of a Cationic Slow-Set Emulsifier
  13. Magnetic Properties of Polyaniline/ZFe2O4 Nanocomposites Synthesized in CTAB as Surfactant and Ionic Liquid
  14. Novel Surfactants
  15. Ionic Liquid in Thin-Layer Chromatography of Anionic Surfactants: Selective Separation of Sodium Deoxycholate and Identification in Commercial Products
  16. Micellar Catalysis
  17. Combination of Best Promoter and Micellar Catalyst for Chromic Acid Oxidation of D-Arabinose in Aqueous Media at Room Temperature
  18. Environmental Chemistry
  19. Photocatalytic Degradation of Copper(II) Palmitates in Non Aqueous Media Using ZnO as Photocatalyst
https://doi.org/10.3139/113.110398
Keywords for this article
Promazine hydrochloride; PMZ; critical micelle concentration; cmc; sodium taurocholate; activity coefficient; Thermodynamic parameters

Articles in the same Issue

  1. Contents/Inhalt
  2. Contents
  3. Hygiene and Washing
  4. Characterization of Microbial Communities in Household Washing Machines
  5. Hygiene in Domestic Laundering – Consumer Behavior in Germany
  6. Timesaving Washing of Textiles Utilizing 38 kHz Ultrasound
  7. Application
  8. Oil Extraction from Oil-Contaminated Drill Cuttings Using a Recyclable Single-Phase O/W Microemulsion
  9. Physical Chemistry
  10. Effect of Sodium Taurocholate on Aggregation Behavior of Amphiphilic Drug Solution
  11. Influence Prediction of Alkylamines Upon Electrical Percolation of AOT-based Microemulsions Using Artificial Neural Networks
  12. Effect of Tween 40 and Tween 60 on the Properties of a Cationic Slow-Set Emulsifier
  13. Magnetic Properties of Polyaniline/ZFe2O4 Nanocomposites Synthesized in CTAB as Surfactant and Ionic Liquid
  14. Novel Surfactants
  15. Ionic Liquid in Thin-Layer Chromatography of Anionic Surfactants: Selective Separation of Sodium Deoxycholate and Identification in Commercial Products
  16. Micellar Catalysis
  17. Combination of Best Promoter and Micellar Catalyst for Chromic Acid Oxidation of D-Arabinose in Aqueous Media at Room Temperature
  18. Environmental Chemistry
  19. Photocatalytic Degradation of Copper(II) Palmitates in Non Aqueous Media Using ZnO as Photocatalyst
Sign up now to receive a 20% welcome discount
Institutional Access
How does access work?
Have an idea on how to improve our website?
Please write us.
© 2025 De Gruyter Brill
Downloaded on 9.10.2025 from https://www.degruyterbrill.com/document/doi/10.3139/113.110398/html?lang=en
Scroll to top button