Chapters in this book

1. Frontmatter i
2. Contents v
3. Foreword ix
4. Preface xi
5. Acknowledgments xiii
6. Part 1: The Material Surface
7. 1. Surface Characterization of Implant Materials: Biological Implications 3
8. 2. The Biomaterial-Tissue Interface and Its Analogues in Surface Science and Technology 19
9. 3. Surface Reaction Kinetics and Adsorption of Biological Moieties: A Mechanistic Approach to Tissue Attachment 33
10. 4. Titanium and Its Oxide Film: A Substrate for Formation of Apatite 49
11. 5. Titanium: Immersion-Induced Surface Chemistry Changes and the Relationship to Passive Dissolution and Bioactivity 62
12. 6. Kinetics of Mineralization, Demineralization, and Transformation of Calcium Phosphates at Mineral and Protein Surfaces 68
13. 7. Substrate Surface Dissolution and Interfacial Biological Mineralization 76
14. 8. High-Resolution Electron Microscopy of a Bone Implant Interface 89
15. Part 2: Bone Proteins and Other Macromolecules
16. 9. Non-Collagenous Bone Proteins and Their Role in Substrate-Induced Bioactivity 97
17. 10. Role of Adhesive Proteins and Integrins in Bone and Ligament Cell Behavior at the Material Surface 111
18. 11. Non-Endocrine Regulation of Bone Cell Activity 120
19. 12. Osteogenesis Induced by BMP-Coated Biomaterials: Biochemical Principles of Bone Reconstruction in Dentistry 127
20. 13. Ceramic Synthesis using Biological Processes 139
21. Parts 1 and 2 - General Discussion 147
22. Part 3: Cellular Activity at the Interface
23. 14. Inflammatory Cell Response to Bone Implant Surfaces 153
24. 15. Modulation of Cell Activity by Titanium Peroxy Compounds 165
25. 16. Behaviour of Osteoblasts on Micromachined Surfaces 170
26. 17. Osteoblast Reactions to Charged Polymers 181
27. 18. Cell-Mediated Bone Regeneration 199
28. 19. The Influence of Sputtered Bone Substitutes on Cell Growth and Phenotypic Expression 205
29. 20. Early Extracellular Matrix Synthesis by Bone Cells 214
30. 21. Transmission Electron Microscopical Identification of Extracellular Matrix Components using Immunocytochemistry 229
31. 22. Molecular Biological Approaches to Investigate Cell/Biomaterial Interactions 241
32. 23. Biological Cascades of Fracture Healing as Models for Bone-Biomaterial Interfacial Reactions 250
33. 24. Tissue Responses to Bone-Derived and Synthetic Materials 265
34. 25. Hard and Soft Connective Tissue Growth and Repair in Response to Charged Surfaces 275
35. 26. Deposition of Cement-like Matrix on Implant Materials 285
36. 27. Polymer Reactions Resulting in Bone Bonding: A Review of the Biocompatibility of Polyactive 295
37. 28. Comparative Morphology of the Bone Interface with Glass Ceramics, Hydroxyapatite, and Natural Coral 308
38. 29. Interfacial Reactions to Bioactive and Non-bioactive Bone Cements 321
39. 30. Modulation of Bone Ingrowth by Surface Chemistry and Roughness 334
40. 31. Comparative Push-out Data of Bioactive and Non-bioactive Materials of Similar Rugosity 350
41. 32. Quantified Bone Tissue Reactions to Various Metallic Materials with Reference to the So-called Osseointegration Concept 357
42. Part 5: Mechanical Effects on Interfacial Biology
43. 33. Effect of Mechanical Stress on Tissue Differentiation in the Bony Implant Bed 367
44. 34. Quantitative Evaluation of the Effect of Movement at a Porous Coated Implant-Bone Interface 380
45. 35. Bone Ingrowth into Porous Coatings Attached to Prostheses of Differing Stiffness 388
46. 36. Influence of Biomechanical Factors at the Bone-Biomaterial Interface 391
47. 37. Bone Bonding Behavior of Biomaterials with Different Surface Characteristics under Load-Bearing Conditions 406
48. Part 5 - General Discussion: The Effect of Micromotion on Bone Healing 415
49. Part 6: Retrieval Analysis for Interpreting Interfacial Phenomena
50. 38. Bone-Biomaterial Interfaces of Retrieved Implants 419
51. 39. Ultrastructural Investigation and Analysis of the Interface of Retrieved Metal Implants 425
52. 40. Synovial Cells at the Interface with Retrieved Implants 438
53. 41. Phenotypic Characteristics of Inflammatory Cells Derived from Hip Revision Capsules 444
54. 42. Bone Bonding to Retrieved Hydroxyapatite- Coated Human Hip Prostheses 450
55. Part 6 - General Discussion 457
56. Part 7: The Industrial Perception 461
57. Biographical Sketches of Invited Attendees at the Bone-Biomaterial Interface Workshop, Toronto, December 3 and 4, 1990 471
58. Affiliations of Contributing Authors 481
59. Index 487