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Molecular modelling and quantitative structure-activity relationship studies of anatoxin-a and epibatidine derivatives with affinity to rodent nAChR receptors

  • Eduardo Melo EMAIL logo , Sidnei Moura e Silva and Fávero Paula
Published/Copyright: April 15, 2014
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Chemical Papers
From the journal Chemical Papers Volume 68 Issue 8

Abstract

Anatoxin-a and epibatidine are natural toxins with a high affinity to nicotinic acetylcholine receptors (nAChR). Nicotinic ligands have the potential to become novel therapeutic agents for various cognitive disorders such as Alzheimer’s and Parkinson’s diseases. The determination of the physicochemical and biological properties of anatoxin-a and epibatidine derivatives is important because these might lead to the development of new cholinergic therapeutic agents. To study these features, the toxins and a set of their derivatives were subjected to a molecular modelling study and QSAR analysis. The structural analyses indicated that the geometric and steric features are important determinants of the compound’s activities. The descriptors selected for the QSAR model also highlighted the roles of the geometric and steric features, together with the importance of electronic features.

Keywords: molecular modelling; anatoxin-a ; epibatidine; QSAR

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Published Online: 2014-4-15
Published in Print: 2014-8-1

© 2014 Institute of Chemistry, Slovak Academy of Sciences

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https://doi.org/10.2478/s11696-014-0545-7
Keywords for this article
molecular modelling; anatoxin-a; epibatidine; QSAR

Articles in the same Issue

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  2. Determination of nitrites and nitrates in drinking water using capillary electrophoresis
  3. Comparison of digestion methods for determination of total phosphorus in river sediments
  4. Interdisciplinary study on pottery experimentally impregnated with wine
  5. Improvement in γ-decalactone production by Yarrowia sp. after genome shuffling
  6. Development of an effective extraction process for coenzyme Q10 from Artemia
  7. Effect of anions on the structure and catalytic properties of a La-doped Cu-Mn catalyst in the water-gas shift reaction
  8. Effect of apple pomace powder addition on farinographic properties of wheat dough and biscuits quality
  9. Influence of caffeine and temperature on corrosion-resistance of CoCrMo alloy
  10. Cetyltrimethylammonium bromide- and ethylene glycol-assisted preparation of mono-dispersed indium oxide nanoparticles using hydrothermal method
  11. Sol-gel synthesis, characterisation, and photocatalytic activity of porous spinel Co3O4 nanosheets
  12. Solvent-free synthesis of β-enamino ketones and esters catalysed by recyclable iron(III) triflate
  13. Potassium phthalimide-catalysed one-pot multi-component reaction for efficient synthesis of amino-benzochromenes in aqueous media
  14. Organocatalytic SOMO reactions of copper(I)-acetylide and alkylindium compounds with aldehydes
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  16. Efficient one-pot synthesis of 2-hydroxyethyl per-O-acetyl glycosides
  17. Properties of singlet- and triplet-excited states of hemicyanine dyes
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