Adsorption and release of terbinafine hydrochloride: Effects of adsorbents, additives, pH, and temperature
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Zuzana Vitková
,
Jarmila Oremusová
Abstract
The paper describes results obtained within the study of factors affecting the process of an antifungal drug — terbinafine hydrochloride adsorption on two different adsorbents — charcoal and silicagel. The effects of the adsorbent area, pH value, temperature and additives (polymers — methyl cellulose and hydroxypropyl cellulose) were analyzed and their impact on the adsorption of terbinafine was derived. The increase of pH and temperature, and the presence of additives decreased the amount of terbinafine adsorbed on the adsorbents. Terbinafine is currently applied both perorally and topically. Hydrogels, i.e. compositions of a drug, additives and water, are, due to their advantageous properties, preferred topical dosage forms. Mass fraction of additives of 1 % to 4 % were studied from the view point of drug release. This study shows that both the sort and the concentration of polymers influence the drug release from hydrogels significantly.
[1] Abe, I., Kamaya, H., & Ueda, I. (1990). Adsorption of local anaesthetics on activated carbon: Freundlich adsorption isotherms. Journal of Pharmaceutical Sciences, 79, 354–358. DOI: 10.1002/jps.2600790418. http://dx.doi.org/10.1002/jps.260079041810.1002/jps.2600790418Suche in Google Scholar PubMed
[2] Adamson, A. W. (1982). Physical chemistry of surfaces, 4th ed. (pp. 373). New York: Wiley. Suche in Google Scholar
[3] Bouyssou-Gauthier, M. L., & Bonnetblanc, J. M. (1999). Terbinafine. Annales de Dermatologie at de Vénéréologie, 126, 81–89. Suche in Google Scholar
[4] Dai, S. G., Dong, L., & Wang, Z. (1999). Adsorption of surfactants in soil. Zhongguo Huanjing Kexue, 19, 392–396. Suche in Google Scholar
[5] Gupta, A. K., Ryder, J. E., Lynch, L. E., & Tavakkol, A. (2003). The use of terbinafine in the treatment of onychomycosis in adults and special populations: a review of the evidence. Journal of Drugs in Dermatology, 4, 302–308. Suche in Google Scholar
[6] Monti, D., Saccomani, L., Chetoni, P., Burgalasi, S., Saettone, M. F., & Mailland, F. (2005). In vitro transungual permeation of cyclopirox from a hydroxypropyl chitosane-based water-soluble nail lacquer. Drug Development and Industrial Pharmacy, 31, 11–17. DOI: 10.1081/DDC-200043935. 10.1081/DDC-200043935Suche in Google Scholar
[7] Neubert, R. H. H., Gensbugel, C., Jackel, A., & Wartewig, S. (2006). Different physicochemical properties of antimycotic agents are relevant for penetration into and through human nails. Pharmazie, 61, 604–607. Suche in Google Scholar
[8] Oremusová, J., & Vitková, Z. (2007). Adsorption, partition and release balances of terbinafine hydrochloride, part I. Pharmazie, 62, 273–277. DOI: 10.1691/ph.2007.4.6161. Suche in Google Scholar
© 2008 Institute of Chemistry, Slovak Academy of Sciences
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Artikel in diesem Heft
- Application of isotachophoretic and conductometric methods for neomycin trisulphate determination
- A rhodamine-based Hg2+-selective fluorescent probe in aqueous solution
- A simple flow injection spectrophotometric determination method for iron(III) based on O-acetylsalicylhydroxamic acid complexation
- Global optimization for parameter estimation of differential-algebraic systems
- Effect of ethyl acetate on carbohydrate components and crystalline structure of pulp produced in aqueous acetic acid pulping
- Effects of acyl donor type, catalyst type, and reaction conditions on the activity and selectivity of Friedel-Crafts acylation
- Intramolecular MLOH/π and MLNH/π interactions in crystal structures of metal complexes
- A strategy for new macrocycle magnetic materials synthesis
- Rearrangement of N-(3-pyridyl)nitramine
- New Cu(II), Co(II), and Ni(II) complexes with thieno[2,3-b]pyridine and 2-methylthieno[2,3-b]pyridine as ligands: Synthesis and crystal structures
- Synthesis of saccharide precursors for preparation of potential inhibitors of glycosyltranferases
- Simultaneous spectrophotometric determination of minoxidil and tretinoin by the H-point standard addition method and partial least squares
- Adsorption and release of terbinafine hydrochloride: Effects of adsorbents, additives, pH, and temperature
- Determination of alkaloids in Corydalis yanhusuo using hollow-fibre liquid phase microextraction and high performance liquid chromatography
- Chemiluminescence mechanisms of cerium-norfloxacin and its application in urine analysis
- A rapid in vitro assay of cobalamin in human urine and medical tablets using ICP-MS
- Inverse gas chromatographic characterization of Porapak Q as an extractant of pollutants from aqueous media
